| Name | P12 |
|---|---|
| Synonyms | DNA polymerase II subunit 4; p12; DNA polymerase epsilon p12 subunit; DNA polymerase epsilon subunit 4; DNA polymerase epsilon subunit p12; POLE 4; POLE4; DNA polymerase epsilon p12 subunits… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12888217 | Kawa K: facilitates transmitter release at developing synapses: a patch clamp study from Purkinje neurons of the newborn rat. Brain Res Dev Brain Res. 2003 Aug 12;144(1):57-71. From P2 to P12 the frequencies of miniature EPSCs and miniature IPSCs in the Purkinje cells increased by 10-fold or more, suggesting progressive formation of functional synapses during this period. Facilitatory effects of were suppressed by strychnine (1 micro M), a specific blocker of the ionotropic glycine receptor, while the effects were also induced by other glycinergic agonists, including alpha- (1 mM), (1 mM) and (500 micro M). |
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| 19332081 | Mathers DA, McCarthy SM, Cooke JE, Ghavanini AA, Puil E: Effects of the beta-amino acid antagonist TAG on thalamocortical inhibition. Neuropharmacology. 2009 Jun;56(8):1097-105. Epub 2009 Mar 28. We performed whole-cell recordings in 200-250 microm sections and immunocytochemical (ICC) studies in ventrobasal thalamus of rat brain (P12-P14). Stimulation of medial lemniscus evoked inhibitory postsynaptic currents (IPSCs) which were purely glycinergic or (A) ergic, or most commonly mixed glycinergic and (A) ergic responses, based on abolition by strychnine, bicuculline, or combined antagonism. |
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| 9614239 | Kotak VC, Korada S, Schwartz IR, Sanes DH: A developmental shift from GABAergic to glycinergic transmission in the central auditory system. J Neurosci. 1998 Jun 15;18(12):4646-55. GABAergic and glycinergic components were identified by blocking transmission with bicuculline and strychnine (SN), respectively. In the medial limb of LSO, there was a dramatic change in the GABAergic IPSC component, decreasing from 78% at postnatal day 3 (P3)-P5 to 12% at P12-P16. |
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| 9878874 | Jiang Z, Carlin KP, Brownstone RM: An in vitro functionally mature mouse spinal cord preparation for the study of spinal motor networks. Brain Res. 1999 Jan 23;816(2):493-9. Administration of strychnine elicited synchronous activity bilaterally in lumbar ventral roots. Rhythmic alternating locomotor-like activity could be produced by application of a combination of and in animals up to P12. |
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| 15235081 | Bradaia A, Schlichter R, Trouslard J: Role of glial and neuronal transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J Physiol. 2004 Aug 15;559(Pt 1):169-86. Epub 2004 Jul 2. In rats (P12-P16) and in the presence of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and bicuculline, ORG 24598 and ORG 25543 applied individually at a concentration of 10 microm induced a mean inward current of -10/-50 pA at -60 mV and increased significantly the decay time constants of miniature (mIPSCs), spontaneous (sIPSCs) and electrically evoked glycinergic (eIPSCs) inhibitory postsynaptic currents. By contrast, the decay time constant, amplitude and frequency of miniature GABAergic IPSCs recorded in the presence of strychnine were not affected by ORG 24598 and ORG 25543. |
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