Protein Information

Name P22
Synonyms Cytoplasmic dynein heavy chain 1; p22; DHC 1; DHC1; DHC1a; DNCH 1; DNCH1; DNCHC 1…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
12154171 Mangin JM, Guyon A, Eugene D, Paupardin-Tritsch D, Legendre P: Functional glycine receptor maturation in the absence of glycinergic input in dopaminergic neurones of the rat substantia nigra. J Physiol. 2002 Aug 1;542(Pt 3):685-97.

In juvenile rats (P19-P22), both the GlyR main conductance state (46-55 pS) and the mean open time (6.8 ms) were decreased.
The application of 1 microM gabazine blocked spontaneous or evoked inhibitory synaptic current, while the addition of 1 microM strychnine had no effect, suggesting a lack of functional glycinergic synapses on DA neurones.
1(0,0,0,1) Details
8815212 Ramirez JM, Quellmalz UJ, Richter DW: Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. J Physiol. 1996 Mar 15;491 ( Pt 3):799-812.

Blockade of glycine receptors by strychnine increased the frequency of rhythmic XII activity in neonatal and older mice (P0-22).
Spontaneous rhythmic activity in hypoglossal (XII) rootlets is generated at all postnatal stages from postnatal day (P) 0 to P22 in the transverse brainstem slice of mice containing the pre-Botzinger complex (PBC).
1(0,0,0,1) Details