| Name | NMDA receptor 1 |
|---|---|
| Synonyms | GRIN 1; NR1; GRIN1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta 1 precursor; N methyl D aspartate receptor subunit NR1; NMDA receptor 1; NMDA 1… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12930797 | Kinney GG, Sur C, Burno M, Mallorga PJ, Williams JB, Figueroa DJ, Wittmann M, Lemaire W, Conn PJ: The transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy) propyl] potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci. 2003 Aug 20;23(20):7586-91. acts as a necessary coagonist for at the NMDA receptor (NMDAR) complex by binding to the strychnine-insensitive -B binding site on the NR1 subunit. |
81(1,1,1,1) | Details |
| 15523521 | Lavrov I, Cheng J: Activation of NMDA receptors is required for the initiation and maintenance of walking-like activity in the mudpuppy (Necturus Maculatus). Can J Physiol Pharmacol. 2004 Aug-Sep;82(8-9):637-44. Furthermore, application of L-701,324 (a selective antagonist of the strychnine-insensitive site of NMDA receptor) (1-10 micromol/L) also resulted in complete block of the walking-like activity. |
31(0,1,1,1) | Details |
| 17502428 | Smothers CT, Woodward JJ: Pharmacological characterization of -activated currents in HEK 293 cells expressing NR1 and NR3 subunits. J Pharmacol Exp Ther. 2007 Aug;322(2):739-48. Epub 2007 May 14. |
6(0,0,0,6) | Details |
| 8558453 | Standaert DG, Testa CM, Rudolf GD, Hollingsworth ZR: Inhibition of glutamate receptor subunit expression by antisense oligonucleotides reveals their role in striatal motor regulation. J Pharmacol Exp Ther. 1996 Jan;276(1):342-52. After NMDAR1 antisense ODN injection, striatal binding of 3H- to sites was not altered, although strychnine-insensitive 3H- binding sites exhibited a small but significant reduction. Recent studies have revealed that NMDA receptors are heteromeric assemblies of structurally related subunits from two families: NMDAR1, which is required for channel activity, and NMDAR2A-D, which modulate the properties of the channels. |
5(0,0,0,5) | Details |
| 15045581 | Scappaticci AA, Jacques R, Carroll JE, Hufnagel LA, Kass-Simon G: Immunocytochemical evidence for an NMDA1 receptor subunit in dissociated cells of Hydra vulgaris. Cell Tissue Res. 2004 May;316(2):263-70. Epub 2004 Mar 25. They support other behavioral and biochemical evidence for a -sensitive, strychnine-insensitive, glycine receptor in hydra and suggest that the glutamatergic AMPA/kainate- system is an early evolved, phylogenetically old, behavioral control mechanism. |
3(0,0,0,3) | Details |
| 15490133 | Barth A, Nguyen LB, Barth L, Newell DW: -induced neurotoxicity in organotypic hippocampal slice cultures. Exp Brain Res. 2005 Mar;161(3):351-7. Epub 2004 Oct 14. coactivates (NMDA) receptors by binding to a distinct recognition site on the NR1 subunit. Stimulation or inhibition (strychnine) of the inhibitory strychnine-sensitive glycine receptors did not produce any neurotoxicity. |
2(0,0,0,2) | Details |
| 17646495 | Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM: Anesthetic-like modulation of a type A, strychnine-sensitive and N-methyl-d-aspartate receptors by coreleased neurotransmitters. Anesth Analg. 2007 Aug;105(2):386-92. METHODS: We tested this prediction by applying to a NR1/NR2A N-methyl-d-aspartate receptor, to a wild-type alpha (1) beta (2) and anesthetic-resistant alpha (1)(S270I) beta (2) gamma-amino- type A receptor, and to a homomeric alpha (1) wild type and anesthetic-resistant alpha (1) S267I glycine receptor. |
1(0,0,0,1) | Details |
| 9758163 | Paudice P, Gemignani A, Raiteri M: Evidence for functional native NMDA receptors activated by or alone in the absence of glutamatergic coagonist. Eur J Neurosci. 1998 Sep;10(9):2934-44. These receptors may display the triple subunit combination NR1/NR2A/NR2B. This effect of was strychnine-insensitive and could be mimicked by a stereoselective agonist at the NMDA receptor site. |
1(0,0,0,1) | Details |
| 18554813 | Cervetto C, Taccola G: GABAA and strychnine-sensitive glycine receptors modulate -evoked release from rat spinal motoneurons: a possible role in neuroprotection. Neuroscience. 2008 Jul 17;154(4):1517-24. Epub 2008 May 3. -mediated [(3) H] release was completely prevented by MK-801, 5,7-diclorokynurenic acid and ifenprodil, while it was strongly inhibited by a lower external pH, suggesting that the involved NMDA receptors contain NR1 and NR2B subunits. |
1(0,0,0,1) | Details |
| 11738262 | Tapia JC, Mentis GZ, Navarrete R, Nualart F, Figueroa E, Sanchez A, Aguayo LG: Early expression of and (A) receptors in developing spinal cord neurons. Neuroscience. 2001;108(3):493-506. Immunocytochemical studies with NR1 and GluR1 antibodies showed a delayed appearance of and alpha-amino-3--5-methyl-4-isoxazolepropionate (AMPA) receptors respectively. The use of various receptor antagonists (strychnine, bicuculline, DL-2-amino-5-phosphonovalerate [APV], 6-cyano-7-nitroquinoxaline-2,3-dione [CNQX]) revealed that this activity was predominantly glycinergic, and to a smaller extent, GABAergic. |
1(0,0,0,1) | Details |
| 15356198 | Carpenter-Hyland EP, Woodward JJ, Chandler LJ: Chronic induces synaptic but not extrasynaptic targeting of NMDA receptors. J Neurosci. 2004 Sep 8;24(36):7859-68. Neurons exposed to 50 mm for 4 d showed an increase in the colocalization of NMDA receptor type 1 (NR1) clusters with the presynaptic marker protein synapsin. |
1(0,0,0,1) | Details |
| 20092573 | Reed BT, Sullivan SJ, Tsai G, Coyle JT, Esguerra M, Miller RF: The transporter GlyT1 controls receptor coagonist occupancy in the mouse retina. Eur J Neurosci. 2009 Dec;30(12):2308-17. Epub 2009 Dec 10. The interpretation of these studies was simplified by blocking post-synaptic inhibition with picrotoxinin and strychnine. Immunoblots of NMDA receptor subunits (NR1, NR2A and NR2B) in WT and GlyT1 (-/+) animals showed that the NR1 subunits were identical. |
1(0,0,0,1) | Details |
| 7961649 | Kumar KN, Babcock KK, Johnson PS, Chen X, Eggeman KT, Michaelis EK: Purification and pharmacological and immunochemical characterization of synaptic membrane proteins with ligand-binding properties of N-methyl-D-aspartate receptors. J Biol Chem. 1994 Nov 4;269(44):27384-93. The co-purification of -sensitive binding, dizocilpine-sensitive thienylcyclohexyl piperidine (TCP)-binding, and strychnine-insensitive -binding proteins was achieved by this affinity chromatographic procedure. These studies indicate that these two proteins might be components of a complex that has some of the characteristics of NMDA receptors and that neuronal membranes may contain varieties of -like receptors composed of protein subunits that differ from the NMDAR1 and NMDAR2 receptor proteins. |
1(0,0,0,1) | Details |