Protein Information

Name SDCN
Synonyms N Syndecan; SDC 3; SDC3; SDCN; SYND 3; SYND3; Syndecan 3; Syndecan neural type…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
12803134 Wang DS, Zhu HL, Li JS: Beta-alanine acts on glycine receptors in the rat sacral dorsal commissural neurons. Int J Neurosci. 2003 Mar;113(3):293-305.

The results indicate that beta-ALA activates the strychnine-sensitive glycine receptors in the SDCN neurons, and suggest that beta-ALA may act as a functional neurotransmitter in the mammalian SDCN.
82(1,1,1,2) Details
9593814 Wang DS, Xu TL, Pang ZP, Li JS, Akaike N: Taurine-activated chloride currents in the rat sacral dorsal commissural neurons. Brain Res. 1998 May 4;792(1):41-7.

The results indicate that both Tau and Gly act on a strychnine-sensitive site to open the same Cl- channels in the SDCN neurons, and suggest that Tau may act as a functional neurotransmitter in the mammalian SDCN.
7(0,0,1,2) Details
11498962 Wang DS, Xu TL, Li JS: Modulation of glycine-activated chloride currents by substance P in rat sacral dorsal commissural neurons. Sheng Li Xue Bao. 1999 Aug;51(4):361-70.

The modulatory effect of substance P (SP) on strychnine-sensitive glycine (Gly) response was examined in neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN) using nystatin perforated patch recording configuration under voltage-clamp conditions.
6(0,0,1,1) Details
10189117 Xu TL: Gamma-aminobutyric acid-induced responses in acutely dissociated neurons from the rat sacral dorsal commissural nucleus. J Auton Nerv Syst. 1999 Feb 15;75(2-3):156-63.

The electrophysiological and pharmacological properties of GABA-activated Cl- currents (IGABA) were investigated in enzymatically dissociated rat sacral dorsal commissural nucleus (SDCN) neurons using the nystatin perforated patch recording configuration under voltage-clamp conditions.
Bicuculline (BIC) and strychnine (STR) antagonized the IGABA in a concentration-dependent manner.
4(0,0,0,4) Details
10841452 Wang DS, Xu TL, Li JS: 5-HT potentiates GABA- and glycine-activated chloride currents on the same neurons in rat spinal cord. J Hirnforsch. 1999;39(4):531-7.

The electrophysiological and pharmacological properties of GABA- and glycine (Gly)-induced responses were investigated in neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN) using the nystatin perforated patch recording configuration under voltage-clamp conditions.
Bicuculline (BIC) and strychnine (STR) suppressed I (GABA) and I (Gly) in a concentration-dependent manner, although they have different affinities for GABA and Gly. 5-HT potentiated both I (GABA) and I (Gly) via intracellular protein kinase C on the same neurons.
2(0,0,0,2) Details
11367678 Wang DS, Xu TL, Pang ZP, Li JS: [Enhancement of taurine-activated whole-cell currents by serotonin in rat sacral dorsal commissural neurons]. Sheng Li Xue Bao. 1998 Dec;50(6):656-62.

Using nystatin-perforated whole-cell recording configuration, the modulatory effect of serotonin (5-hydroxytryptamine, 5-HT) on taurine (Tau)-activated current (ITau) was investigated in neurons dissociated from the rat sacral dorsal commissural nucleus (SDCN).
The results are as follows: (1) Tau acted on strychnine-sensitive glycine (Gly) receptors and elicited inward currents at a holding potential (VH) of -40 mV in SDCN neurons; (2) in a range of 0.01 to 100 mumol/L, 5-HT enhanced ITau in a concentration-dependent manner; (3) both the reversal potential of Tau and the binding affinity of Tau to Gly receptor were not affected by 5-HT; (4) when the neurons were loaded with 3 mumol/L chelerythrine, application of 1 mumol/L 5-HT failed to enhance ITau.
2(0,0,0,2) Details