| Name | ATPase |
|---|---|
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15926343 | Menzikov SA, Menzikova OV: [Effect of and strychnine on Cl (-)-activated Mg2+-ATPase from bream brain microsomes (Abamis brama L.)]. Izv Akad Nauk Ser Biol. 2001 Nov-Dec;(6):760-3. |
249(3,3,4,4) | Details |
| 11952420 | Menzikov SA, Menzikova OV: Effect of activators and blockers of ligand-regulated ion channels on the activity of the Cl-stimulated Mg2+-ATPase of the plasma membrane fraction from bream (Abramis brama L.) brain. Biochemistry. 2002 Feb;67(2):233-9. The activation of "basal" Mg (2+)-ATPase by neuromediators was decreased by blockers of the corresponding receptors (picrotoxin, strychnine, benztropine mesylate, and D-2-amino-5-phosphonovaleric acid). |
166(2,2,2,6) | Details |
| 12325312 | Kurup RK, Kurup PA: Central role of hypothalamic in conscious perception, neuroimmunoendocrine integration, and coordination of cellular function: relation to hemispheric dominance. Int J Neurosci. 2002 Jun;112(6):705-39. can also preferentially upregulate transport over resulting in increased levels of depolarizng catabolites, strychnine, and and decreased levels of hyperpolarizing catabolites, and morphine, contributing to membrane Na (+)-K+ ATPase inhibition in all the above disorders and the indexed family. |
84(1,1,1,4) | Details |
| 12606243 | Kurup RK, Kurup PA: Hypothalamic --central role in conscious perception, neuroimmunoendocrine integration and coordination of cellular function--relation to hemispheric dominance. Med Hypotheses. 2003 Feb;60(2):243-57. can also preferentially upregulate transport over resulting in increased levels of depolarising catabolites - strychnine and and decreased levels of hyperpolarising catabolites and morphine contributing to membrane Na (+)-K (+) ATPase inhibition in all the above disorders and the indexed family. |
83(1,1,1,3) | Details |
| 11116526 | Ravikumar A, Arun P, Devi KV, Kurup PA: Endogenous strychnine, and morphine--description of hypo and hyper-strychninergic, nicotinergic and morphinergic state in relation to neuropsychiatric diseases. Indian J Exp Biol. 2000 Jun;38(6):559-66. The role of morphine, strychnine and in the pathogenesis of these disorders in the setting of membrane Na (+)-K+ ATPase inhibition is discussed. |
39(0,1,2,4) | Details |
| 12587524 | Kurup RK, Kurup PA: Endogenous strychnine: description of hypo- and hyperstrychninergic state in relation to neuropsychiatric diseases. Int J Neurosci. 2002 Oct;112(10):1229-41. The role of strychnine in the pathogenesis of these disorders, in the setting of membrane Na (+)-K+ ATPase inhibition, is discussed. |
39(0,1,2,4) | Details |
| 12856480 | Kurup RK, Kurup PA: Hypothalamic -mediated model for Parkinson's disease. Int J Neurosci. 2003 Apr;113(4):515-36. The isoprenoid pathway produces four key metabolites important in cellular function-- (endogenous membrane Na (+)-K+ ATPase inhibitor), (important in N-glycosylation of proteins), (free-radical scavenger), and (component of cellular membranes). Serum strychnine, and were elevated, while morphine, and were decreased. |
2(0,0,0,2) | Details |
| 11964523 | Kurup RK, Kurup PA: Hypothalamic hemispheric dominance and the acquired immunodeficiency syndrome. Neuroimmunomodulation. 2001;9(5):286-94. OBJECTIVES: Hypothalamic an isoprenoidal metabolite, is an endogenous regulator of membrane Na (+)-K (+) ATPase activity, immune activation and synaptic neurotransmission. The catabolites and strychnine) were increased and the catabolites (morphine, and were reduced. |
2(0,0,0,2) | Details |
| 12858216 | Kurup R, Nair RA, Kurup PA: Isoprenoid pathway related cascade in multiple myeloma. . Pathol Oncol Res. 2003;9(2):107-14. Epub 2003 Jul 14. There was elevation in plasma HMG reductase activity, serum and and a reduction in RBC membrane Na+ - K+ ATPase activity, and serum levels. Serum strychnine and were elevated while and morphine were decreased. |
1(0,0,0,1) | Details |
| 12751436 | Kurup RK, Kurup PA: Hypothalamic hemispheric chemical dominance, and addictive behavior. Int J Neurosci. 2003 Feb;113(2):279-89. The isoprenoid pathway produces an endogenous membrane - ATPase inhibitor, There was an increase in catabolites-- and strychnine--in patients with addiction, and a reduction in catabolites-- noradrenatine, and morphine. |
1(0,0,0,1) | Details |
| 8770653 | Baker RE, Ballantyne D, Bingmann D, Jones D, Widman G: Rhythm generation in organotypic medullary cultures of newborn rats. Int J Dev Neurosci. 1995 Dec;13(8):799-809. The organic antagonists and flunarizine (50-100 microM each) and the inorganic antagonists (2 mM) and (6 mM) suppressed periodic activity and abolished or weakened the chemosensitivity towards CO2/acidosis. (6) Dantrolene (10 microM). an inhibitor of intracellular release decreased the periodicity, while thapsigargin (2 microM) which blocks endoplasmic Ca (2+)-ATPase, transiently accelerated the occurrence of periodic events. (7) Oscillations of intracellular free concentrations in Fura-2 AM-loaded cells were weakened or abolished by (2 mM). Our findings showed that (1) Exposure to tetrodotoxin (0.2 microM) or to high (6 mM) and low (0.2 mM) concentrations abolished periodic activity. (2) Neither the blockade of GABAergic potentials with bicuculline methiodide (200 microM) and/or hydroxysaclofen (200 microM) nor the blockade of glycinergic potentials with strychnine hydrochloride (100 microM) abolished rhythmicity. (3) While atropine sulphate (5 microM) was ineffective in modulating periodic discharges (100 microM) - like CO2-shortened the intervals between the periodic events; hexamethonium (50-100 microM) reduced both periodic and aperiodic activity. (4) Exposure to the antagonist 2-aminophosphonovaleric acid (50 microM) suppressed periodic events only transiently. |
1(0,0,0,1) | Details |
| 12803139 | Kurup RK, Kurup PA: Hypothalamic hemispheric chemical dominance, and Alzheimer's disease. Int J Neurosci. 2003 Mar;113(3):361-81. There was elevation in plasma HMG reductase activity, serum and levels, and a reduction in serum RBC membrane Na (+)-K+ ATPase activity, and serum levels. Serum strychnine, and were elevated, while serum morphine, and were decreased. |
1(0,0,0,1) | Details |
| 20331561 | Adermark L, Clarke RB, Olsson T, Hansson E, Soderpalm B, Ericson M: Implications for glycine receptors and astrocytes in -induced elevation of levels in the nucleus accumbens. Addict Biol. 2010 Mar 10. ABSTRACT Elevated levels are believed to contribute to the rewarding sensation of (EtOH), and previous research has shown that strychnine-sensitive glycine receptors in the nucleus accumbens (nAc) are involved in regulating release and in mediating the reinforcing effects of EtOH. The EtOH-induced cell swelling was inhibited in cultures treated with the Na (+)/K (+)/2Cl (-) cotransporter blocker (1 mM), Na (+)/K (+)-ATPase inhibitor ouabain (0.1 mM), potassium channel inhibitor BaCl (2) (50 microM) and in cultures containing low extracellular concentration (3 mM). |
1(0,0,0,1) | Details |
| 14602544 | Kurup RK, Kurup PA: Hypothalamic hemispheric chemical dominance, and oncogenesis: evidence from multiple myeloma. Int J Neurosci. 2003 Dec;113(12):1719-40. There was elevation in plasma HMG reductase activity, serum and and a reduction in RBC membrane Na (+)-K+ ATPase activity, serum and levels. Serum strychnine, and were elevated, while and morphine were decreased. |
1(0,0,0,1) | Details |
| 14602545 | Kurup RK, Kurup PA: Hypothalamic hemispheric chemical dominance, and mesenteric artery occlusion. Int J Neurosci. 2003 Dec;113(12):1741-60. The RBC membrane Na (+)-K+ ATPase activity and serum were decreased. |
1(0,0,0,1) | Details |
| 14692193 | Kurup RK, Kurup PA: Hypothalamic -mediated model for trisomy 21. . Pediatr Pathol Mol Med. 2003 Sep-Oct;22(5):411-22. Membrane Na+, K (+)-ATPase activity, serum and were decreased while methyl (HMG) reductase activity, serum and levels were increased in trisomy 21. There were increased levels of catabolites-- strychnine, and --and decreased levels of catabolites-- and morphine in trisomy 21. |
1(0,0,0,1) | Details |
| 12134182 | Kumar AR, Kurup PA: Endogenous - ATPase inhibition related biochemical cascade in trisomy 21 and Huntington's disease: neural regulation of genomic function. Neurol India. 2002 Jun;50(2):174-80. There were increased levels of catabolites strychnine, and and decreased levels of catabolites and morphine) in both trisomy 21 and Huntington's disease. |
1(0,0,0,1) | Details |