| Name | tyrosine hydroxylase |
|---|---|
| Synonyms | Putative tyrosine hydroxylase variant; TH; TH protein; TYH; Truncated tyrosine hydroxylase; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine hydroxylase… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10669492 | Hayar A, Guyenet PG: Prototypical imidazoline-1 receptor ligand moxonidine activates alpha2-adrenoceptors in bulbospinal neurons of the RVL. J Neurophysiol. 2000 Feb;83(2):766-76. This current was observed in both tyrosine hydroxylase-immunoreactive and other bulbospinal neurons and was blocked by SKF 86466. Excitatory postsynaptic currents (EPSCs) evoked by focal electrical stimulation were isolated by incubation with gabazine and strychnine, and inhibitory postsynaptic currents (IPSCs) were isolated with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). |
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| 9219856 | Kanthasamy AG, Kanthasamy A, Matsumoto RR, Vu TQ, Truong DD: Neuroprotective effects of the strychnine-insensitive site antagonist (R)-HA-966 in an experimental model of Parkinson's disease. Brain Res. 1997 Jun 6;759(1):1-8. Pretreatment with (R)-HA-966 also significantly protected the degeneration of tyrosine hydroxylase-positive neurons in the substantia nigra of mice treated with MPTP and alleviated the acute behavioral changes caused by the neurotoxin. |
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| 8594938 | Li YW, Bayliss DA, Guyenet PG: C1 neurons of neonatal rats: intrinsic beating properties and alpha 2-adrenergic receptors. Am J Physiol. 1995 Dec;269(6 Pt 2):R1356-69. Tyrosine-hydroxylase-immunoreactive (TH-ir) neurons (C1 cells) of the rostral ventrolateral medulla (RVL) control sympathetic tone and may be inhibited by the hypotensive drug clonidine. Blockade of fast postsynaptic potentials with plus bicuculline plus strychnine or with a low-Ca (2+)-high-Mg2+ medium failed to reduce their firing rate. |
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| 9772256 | Hayar A, Guyenet PG: Pre- and postsynaptic inhibitory actions of methionine-enkephalin on identified bulbospinal neurons of the rat RVL. J Neurophysiol. 1998 Oct;80(4):2003-14. Thirty-five percent of the recorded neurons were found to be tyrosine hydroxylase immunoreactive (C1 neurons). The remaining mPSCs had much slower kinetics (decay time = 19.6 ms) and were GABAergic [miniature inhibitory postsynaptic currents (mIPSCs)] as they were blocked by gabazine (3 microM) but not by strychnine (3-10 microM). |
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| 9895138 | Toru M: Biological research on schizophrenia. . Psychiatry Clin Neurosci. 1998 Dec;52 Suppl:S170-2. Glutamate receptors, such as the kainate receptor labeled by 3H-kainate, the (NMDA) receptor by 3H MK801, and the strychnine-insensitive sites in the NMDA receptor by 3H- increased significantly in various cortical areas of schizophrenic brains. Measurement of tyrosine hydroxylase activity and dopamine D2 receptor in the schizophrenic brain provided evidence of hyperdopaminergia. |
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