| Name | NK1 |
|---|---|
| Synonyms | BY55; CD160; CD160 antigen; CD160 antigen precursor; CD160 molecule; NK1; NK28; Natural killer cell receptor BY55… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8867090 | Cammack C, Logan SD: Excitation of rat sympathetic preganglionic neurones by selective activation of the NK1 receptor. J Auton Nerv Syst. 1996 Feb 5;57(1-2):87-92. In 3 neurones, GR73632 evoked both a depolarising response and inhibitory postsynaptic potentials (IPSPs) and in the one neurone tested, the IPSPs were blocked by strychnine (20 microM), suggesting that NK1 receptors may also be found upon inhibitory glycinergic interneurones. |
35(0,1,1,5) | Details |
| 9331923 | Heppenstall PA, Fleetwood-Walker SM: Glycine receptor regulation of neurokinin1 receptor function in rat dorsal horn neurones. Neuroreport. 1997 Sep 29;8(14):3109-12. Activation of spinal neurokinin1 (NK1) receptors leads to increases in the extracellular concentration of in the dorsal horn. However, in the presence of the antagonists, strychnine or phenylbenzene-omega-phosphono-alpha-amino acid (PMBA), GR82334 displayed inhibitory properties. |
4(0,0,0,4) | Details |
| 16467532 | Torsney C, MacDermott AB: Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. J Neurosci. 2006 Feb 8;26(6):1833-43. Lamina I and III neurokinin 1 (NK1) receptor expressing (NK1R+) dorsal horn neurons, many of which are projection neurons, are required for the development of this hypersensitivity and are therefore likely to be a component of this proposed pathway. Blockade of local GABAergic and glycinergic inhibition with bicuculline (10 microm) and strychnine (300 nm), respectively, revealed significant A fiber input to lamina I NK1R+ neurons that was predominantly Abeta fiber mediated. |
2(0,0,0,2) | Details |
| 19348729 | Han SK, Park SA, Jeon JG, Chang KW, Ahn DK, Oh SB, Park SJ: Functional type I vanilloid receptor expression by substantia gelatinosa neurons of trigeminal subnucleus caudalis in mice. Neurosci Lett. 2009 Mar 20;452(3):228-31. Epub 2009 Jan 29. -induced depolarization was maintained in 20 out of 32 (63%) SG neurons in the presence of amino acid and voltage-dependent sodium channel blockers (10 microM CNQX, 20 microM AP-5, 0.5 microM TTX, 50 microM picrotoxin and 2 microM strychnine). In addition, -induced depolarization was maintained in the presence of L-732,138 (1 microM), an NK1 receptor antagonist, in 14 out of 17 neurons (82%) tested. |
1(0,0,0,1) | Details |
| 11498962 | Wang DS, Xu TL, Li JS: Modulation of -activated currents by substance P in rat sacral dorsal commissural neurons. Sheng Li Xue Bao. 1999 Aug;51(4):361-70. The modulatory effect of substance P (SP) on strychnine-sensitive (Gly) response was examined in neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN) using nystatin perforated patch recording configuration under voltage-clamp conditions. |
0(0,0,0,0) | Details |
| 7684071 | Calligaro DO, O'Malley PJ, Monn JA: beta-Amyloid (25-35) or substance P stimulates [3H] MK-801 binding to rat cortical membranes in the presence of and J Neurochem. 1993 Jun;60(6):2297-303. The compounds do not appear to act through the strychnine-insensitive binding site because neither beta-amyloid (25-35) nor substance P displaced [3H] binding. |
0(0,0,0,0) | Details |
| 19244526 | Miraucourt LS, Moisset X, Dallel R, Voisin DL: inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia. J Neurosci. 2009 Feb 25;29(8):2519-27. First, we showed that disinhibition with strychnine selectively induced dynamic but not static mechanical allodynia. |
0(0,0,0,0) | Details |