Protein Information

Name orexin
Synonyms HCRT; PPOX; Hcrt; Hypocretin; Hypocretin neuropeptide; OX; Orexin; Orexin precursor…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
14551290 Cheng JK, Chou RC, Hwang LL, Chiou LC: Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain. J Pharmacol Exp Ther. 2003 Dec;307(3):1065-71. Epub 2003 Oct 9.

Orexin A antibody, SB-334867, suramin, strychnine, or naloxone enhanced the incision-induced allodynic response.
15(0,0,1,10) Details
11790816 Grudt TJ, van den Pol AN, Perl ER: Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat. J Physiol. 2002 Jan 15;538(Pt 2):517-25.

The sIPSC increase was blocked by strychnine (1 microM) and by TTX (1 microM), suggesting that the increased sIPSC frequency was glycine and action potential dependent.
8(0,0,0,8) Details