| Name | 5 HT2 |
|---|---|
| Synonyms | 5 HT 2; 5 HT 2A; 5 HT2; 5 HT2A; 5 hydroxytryptamine (serotonin) receptor 2A; 5 hydroxytryptamine 2A receptor; 5 hydroxytryptamine receptor 2A; HTR 2… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8319089 | Lewis DI, Sermasi E, Coote JH: Excitatory and indirect inhibitory actions of on sympathetic preganglionic neurones in the neonate rat spinal cord in vitro. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):596-604. Epub 2009 Mar 3. The -induced IPSPs were reversibly blocked by superfusion with strychnine, suggesting they were mediated by The results suggest that the excitatory action of on SPN is mediated via an atypical 5-HT2 receptor or a 5-HT1C-like receptor. |
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| 12372564 | Li H, Kang JF, Li YQ: potentiation of -activated whole-cell currents in the superficial laminae neurons of the rat spinal dorsal horn is mediated by protein kinase C. Brain Res Bull. 2002 Sep 30;58(6):593-600. Gly acted on strychnine (STR)-sensitive Gly receptors and elicited inward Cl (-) currents (I (Gly)) at a holding potential of -40 mV; (2). 5-HT potentiated I (Gly) without affecting the reversal potential of I (Gly); (3). the agonist (alpha-methyl- and antagonist (ketanserine) of 5-HT (2) receptor mimicked and blocked the potentiating effect of on I (Gly), respectively; (4). bisindolylmaleimide I (BIM), a selective inhibitor of protein kinase C (PKC), reduced the potentiating effect of on I (Gly); and (5). -induced enhancement of I (Gly) was not affected by pretreatment with 1,2-bis-(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid tetrakis (acetoxy-methyl) ester (BAPTA AM), a Ca (2+) chelator. These results indicate that (1). the potentiation of on I (Gly) is mediated by 5-HT (2) receptor and through Ca (2+)-independent PKC intracellular signal transduction pathway; and (2). the interactions between and Gly might modulate the transmission of nociceptive information through the spinal cord. |
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| 16760346 | Harvey PJ, Li X, Li Y, Bennett DJ: Endogenous monoamine receptor activation is essential for enabling persistent currents and repetitive firing in rat spinal motoneurons. J Neurophysiol. 2006 Sep;96(3):1171-86. Epub 2006 Jun 7. Application of 5-HT2A, 5-HT2C, and alpha1-NE receptor antagonists (ketanserin, RS 102221, and WB 4101, respectively) significantly reduced the Na PICs, and a combined application of these three monoamine antagonists completely eliminated the Na PIC, in both acute and chronic spinal rats. |
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| 19268504 | Papiez MA, Dybala M, Sowa-Kucma M, Krzysciak W, Taha H, Jozkowicz A, Nowak G: Evaluation of oxidative status and depression-like responses in Brown Norway rats with acute myeloid leukemia. table of contents. A significant increase in the potency of to displace [(3) H] L-689,560 from the strychnine-insensitive site of the N-methyl-D-aspartic (NMDA) receptors receptor complex in cortical homogenates of the leukemic rats in 30- and 34-day experimental series was observed in comparison with the control. |
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| 8894185 | Green KA, Lambert JJ, Cottrell GA: Ligand-gated ion channels opened by in molluscan neurones. Br J Pharmacol. 1996 Oct;119(3):602-8. The responses were also antagonized by the non-specific antagonists (+)-tubocurarine and strychnine. 4. |
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| 12651653 | Koshizaki M, Kawamata M, Shimada SG, Saito Y, Collins JG: 5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons. Anesth Analg. 2003 Apr;96(4):1027-31 We recently reported that type A- and strychnine-sensitive glycine receptor systems partially mediate halothane depression of spinal dorsal horn low-threshold neurons. |
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