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Ahmadiani A, Mandgary A, Sayyah M: Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors. Epilepsia. 2003 May;44(5):629-35.
PURPOSE: There is some structural similarity between the androgen receptor antagonist, flutamide (Flut) and benzodiazepines (BZDs).
METHODS: (a) Different groups of mice each were pretreated i.p. with Flut, and after 0.5 h, they received chemoconvulsants [pentylenetetrazole (PTZ), bicuculline, aminophylline, strychnine or kainic acid]. |
1(0,0,0,1) |
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