Protein Information

Name E14
Synonyms E14; E14 gene; E14 protein; NPAT; NPAT protein; E14 genes; E14 proteins; NPAT proteins

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
17418495 Fujii M, Arata A, Kanbara-Kume N, Saito K, Yanagawa Y, Obata K: Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter. Neuroscience. 2007 May 25;146(3):1044-52. Epub 2007 Apr 5.

Strychnine reversed inspiratory-phase hyperpolarization to large depolarization in expiratory neurons.
To further evaluate the involvement of GABA and glycine in fetal respiratory function, we studied neural activities in brainstem-spinal cord blocks prepared from GAD65-/-:67-/- and vesicular GABA transporter (VGAT)-/-mice on embryonic day 14 (E14)-E15 and E18.
2(0,0,0,2) Details
8558472 Zhang ZW, Berg DK: Patch-clamp analysis of glycine-induced currents in chick ciliary ganglion neurons. J Physiol. 1995 Sep 1;487 ( Pt 2):395-405.

The mean peak current was about 60-fold larger at E14 than at E8 and vastly exceeded changes in cell size.
Strychnine reversibly inhibited the glycine-induced responses.
1(0,0,0,1) Details