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Namba T, Morimoto K, Yamada N, Otsuki S: Antiepileptogenic action of 7-chlorokynurenic acid on amygdala kindling of rats. Pharmacol Biochem Behav. 1993 Oct;46(2):275-81.
To investigate the role of strychnine-insensitive glycine receptors in epilepsy, we studied the effects of 7-chlorokynurenic acid (7-CK), a selective strychnine-insensitive glycine receptor antagonist, on amygdala kindling development and previously amygdala-kindled seizures in rats.
ICV administration of 7-CK (10 or 20 micrograms) suppressed amygdala kindling development, according to the motor seizure stage and afterdischarge development, in a dose-dependent manner. |
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