Protein Information

Name Frings
Synonyms CARP 2; Caspase regulator CARP2; Caspases 8 and 10 associated RING finger protein 2; FYVE RING finger protein Sakura; Fring; Likely ortholog of mouse Rififylin; RFFL; RING finger and FYVE like domain containing protein 1…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
9169290 Kehne JH, Kane JM, Chaney SF, Hurst G, McCloskey TC, Petty MA, Senyah Y, Wolf HH, Zobrist R, White HS: Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties. Epilepsy Res. 1997 Apr;27(1):41-54.

MDL 27,192 demonstrated anticonvulsant activity in a wide range of epilepsy models that are genetically-based (audiogenic seizures in the seizure susceptible DBA/2J or Frings mouse; spike wave seizures in genetic absence epilepsy rats of Strasbourg (GAERS), electrically-based (MES seizures in mice and rats, corneally-kindled seizures in rats) and chemically-based (bicuculline, PTZ, picrotoxin, 3-mercaptopropionic acid, quinolinic acid and strychnine).		 6(0,0,1,1) Details
7713059 White HS, Harmsworth WL, Sofia RD, Wolf HH: Felbamate modulates the strychnine-insensitive glycine receptor. . Epilepsy Res. 1995 Jan;20(1):41-8.

In the Frings audiogenic seizure-susceptible mouse model of reflex epilepsy, the glycine agonist D-serine (150 nmol, i.c.v.) completely blocked the anticonvulsant activity of a maximally effective dose of felbamate (19 mg/kg, i.p.).		 2(0,0,0,2) Details