Protein Information

Name AMPA 2
Synonyms AMPA 2; AMPA selective glutamate receptor 2; AMPA2; GLUR2; GLURB; GRIA 2; GRIA2; GluR 2…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
7834343 Ball EF, Shaw PJ, Ince PG, Johnson M: The distribution of excitatory amino acid receptors in the normal human midbrain and basal ganglia with implications for Parkinson's disease: a quantitative autoradiographic study using [3H] MK-801, [3H] glycine, [3H] CNQX and [3H] kainate. Brain Res. 1994 Sep 26;658(1-2):209-18.

The distribution and density of ligand binding representing N-methyl-D-aspartate (NMDA), AMPA (2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) and kainate receptors has a heterogeneous distribution in the human midbrain and basal ganglia.
In the substantia nigra relatively high densities of [3H] MK-801 and strychnine-insensitive [3H] glycine binding sites representing NMDA receptors were present, whereas only moderate densities of [3H] CNQX and [3H] kainate binding sites were present, compared to other regions.
1(0,0,0,1) Details
7687279 Boos R, Schneider H, Wassle H: Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina. J Neurosci. 1993 Jul;13(7):2874-88.

Four agonists of excitatory amino acid receptors--kainate (KA), AMPA, 2-amino-4-phosphonobutyrate (APB), and NMDA--were tested.
GABA as well as glycine activated Cl- channels, which could be blocked by bicuculline and strychnine, respectively.
1(0,0,0,1) Details