| Name | G protein coupled receptors |
|---|---|
| Synonyms | ASRT 2; ASRT2; G protein coupled receptor 154; G protein coupled receptor for asthma susceptibility; G protein coupled receptor; G protein coupled receptor PGR14; GPR154; GPRA… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7651370 | Lazareno S, Birdsall NJ: Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and at muscarinic receptors. Mol Pharmacol. 1995 Aug;48(2):362-78. |
82(1,1,1,2) | Details |
| 17253962 | Sainz E, Cavenagh MM, Gutierrez J, Battey JF, Northup JK, Sullivan SL: Functional characterization of human bitter taste receptors. . Biochem J. 2007 May 1;403(3):537-43. The T2Rs belong to a multi-gene family of G-protein-coupled receptors responsible for the detection of ingested bitter-tasting compounds. We also demonstrate that hT2R14 is a receptor for aristolochic acid and report the first characterization of the ligand specificities of hT2R7, which is a broadly tuned receptor responding to strychnine, quinacrine, chloroquine and papaverine. |
1(0,0,0,1) | Details |
| 9671782 | Ming D, Ruiz-Avila L, Margolskee RF: Characterization and solubilization of bitter-responsive receptors that couple to gustducin. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8933-8. The tastes of many bitter and sweet compounds are thought to be transduced via nucleotide binding protein (G-protein)-coupled receptors, although the biochemical nature of these receptors is poorly understood at present. In this paper, we show that gustducin is expressed in bovine taste tissue and that both gustducin and transducin, in the presence of bovine taste membranes, can be activated specifically by several bitter compounds, including denatonium, quinine, and strychnine. |
1(0,0,0,1) | Details |