| Name | PARP |
|---|---|
| Synonyms | COL11A2; PARP; Collagen alpha 2(XI) chain; Collagen alpha 2(XI) chain precursor; Collagen type XI alpha 2; Collagen type XI alpha 2 isoform 1; DFNA13; DFNB53… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12142990 | Lansiaux A, Bailly C, Houssier C, Colson P, De Pauw-Gillet MC, Frederich M, Tits M, Angenot L: Apoptosis of HL-60 leukemia cells induced by the bisindole alkaloids sungucine and isosungucine from Strychnos icaja. Planta Med. 2002 Jul;68(7):591-5. Western blotting analysis reveals that the two alkaloids induce cleavage of the poly (ADP- polymerase (PARP) and promote the cleavage of a caspase-3 DEVD peptide substrate. |
1(0,0,0,1) | Details |
| 12644898 | Frederich M, Bentires-Ali M, Tits M, Angenot L, Heinen E, De Pauw-Gillet MC: Apoptosis induction in human cancer cells by sungucine from Strychnos icaja root. Naunyn Schmiedebergs Arch Pharmacol. 2003 Mar;367(3):260-5. Epub 2003 Feb 14. The cleavage of PARP by caspase-3 protease proved that apoptosis was also induced in this line. |
1(0,0,0,1) | Details |