Protein Information

Name CACA
Synonyms CACA; CCA 3; CCA3; CRYG 4; CRYG4; CRYGD; Gamma crystallin 4; Gamma crystallin D…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
7947393 Boatright JH, Rubim NM, Iuvone PM: Regulation of endogenous dopamine release in amphibian retina by gamma-aminobutyric acid and glycine. Vis Neurosci. 1994 Sep-Oct;11(5):1003-12.

Exogenous glycine inhibited light-stimulated dopamine release in a concentration-dependent and strychnine-sensitive manner.
Exogenous GABA, the GABA-A receptor agonist muscimol, the GABA-B receptor agonist baclofen, and the GABA-C receptor agonist cis-aminocrotonic acid (CACA) suppressed light-evoked dopamine overflow from eyecups.
2(0,0,0,2) Details
8386310 Woodward RM, Polenzani L, Miledi R: Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. Mol Pharmacol. 1993 Apr;43(4):609-25.

Conformationally restricted GABA analogues trans- and cis-4-aminocrotonic acid (TACA and CACA) were agonists at the rho-like receptors.
Strychnine (Kb congruent to 70) and SR-95531 (Kb congruent to 35) also were competitive inhibitors of the rho-like receptors but were, respectively, 20 and 240 times more potent at GABAA receptors.
2(0,0,0,2) Details
14673187 Whyment AD, Wilson JM, Renaud LP, Spanswick D: Activation and integration of bilateral GABA-mediated synaptic inputs in neonatal rat sympathetic preganglionic neurones in vitro. J Physiol. 2004 Feb 15;555(Pt 1):189-203. Epub 2003 Dec 12.

In three neurones IPSPs evoked by stimulation of the iLF (n = 1) or cLF (n = 2) were partly sensitive to strychnine (2 microM).
The GABA (C) receptor agonist CACA (200 microM) was without significant effect on SPNs.
1(0,0,0,1) Details
7623156 Zhou ZJ, Fain GL: Neurotransmitter receptors of starburst amacrine cells in rabbit retinal slices. J Neurosci. 1995 Jul;15(7 Pt 2):5334-45.


Glycine (30-200 microM) also activated a Cl- conductance in starburst cells, which could be completely blocked by strychnine.
0(0,0,0,0) Details