Protein Information

Name P16
Synonyms ARF; P19; p14; MTS 1; MTS1; CDK4 inhibitor; CDK4I; CDKN 2…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
9614239 Kotak VC, Korada S, Schwartz IR, Sanes DH: A developmental shift from GABAergic to glycinergic transmission in the central auditory system. J Neurosci. 1998 Jun 15;18(12):4646-55.

GABAergic and glycinergic components were identified by blocking transmission with bicuculline and strychnine (SN), respectively.
In the medial limb of LSO, there was a dramatic change in the GABAergic IPSC component, decreasing from 78% at postnatal day 3 (P3)-P5 to 12% at P12-P16.
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15235081 Bradaia A, Schlichter R, Trouslard J: Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J Physiol. 2004 Aug 15;559(Pt 1):169-86. Epub 2004 Jul 2.

In rats (P12-P16) and in the presence of kynurenic acid, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and bicuculline, ORG 24598 and ORG 25543 applied individually at a concentration of 10 microm induced a mean inward current of -10/-50 pA at -60 mV and increased significantly the decay time constants of miniature (mIPSCs), spontaneous (sIPSCs) and electrically evoked glycinergic (eIPSCs) inhibitory postsynaptic currents.
By contrast, the decay time constant, amplitude and frequency of miniature GABAergic IPSCs recorded in the presence of strychnine were not affected by ORG 24598 and ORG 25543.
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14741396 Shibata S, Kakazu Y, Okabe A, Fukuda A, Nabekura J: Experience-dependent changes in intracellular Cl- regulation in developing auditory neurons. Neurosci Res. 2004 Feb;48(2):211-20.


Implanted strychnine pellets also prevented the decrease in [Cl-](i) in most neurons.
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