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Schilling T, Eder C: A novel physiological mechanism of glycine-induced immunomodulation: Na+-coupled amino acid transporter currents in cultured brain macrophages. J Physiol. 2004 Aug 15;559(Pt 1):35-40. Epub 2004 Jul 8.
We suggest that glycine mediates its effects by activation of system A Na (+)-coupled neutral amino acid transporters.
Glycine-evoked currents of brain macrophages were unaffected by strychnine, Cl (-)-free extracellular solution, N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy) propyl]) sarcosine (NFPS) and amoxapine, but were abolished upon omission of extracellular Na (+). |
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