Protein Information

Name T13
Synonyms ANCO 1; ANCO1; ANKRD11; Ankyrin repeat domain 11; Ankyrin repeat domain containing protein 11; Ankyrin repeat containing cofactor 1; LZ16; Nasopharyngeal carcinoma susceptibility protein…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
7897483 Wall PD, Bennett DL: Postsynaptic effects of long-range afferents in distant segments caudal to their entry point in rat spinal cord under the influence of picrotoxin or strychnine. J Neurophysiol. 1994 Dec;72(6):2703-13.

On one side dorsal roots T12, T13, and L1 were intact but all more caudal roots on that side were cut.
1(0,0,0,1) Details
12909685 Iizuka M: GABAA and glycine receptors in regulation of intercostal and abdominal expiratory activity in vitro in neonatal rat. J Physiol. 2003 Sep 1;551(Pt 2):617-33. Epub 2003 Aug 8.

Under normal pH conditions, application of strychnine (0.2- 2.0 microM; a glycine receptor antagonist) to the brainstem did not evoke expiratory bursts.
Expiratory activity in internal intercostal muscle, internal oblique muscle or T13 ventral root was evoked by a decrease in perfusate pH from 7.4 to 7.1 (i.e. from normal to low pH conditions) and was limited to the first part of the expiratory phase.
1(0,0,0,1) Details
9084588 Kremer E, Lev-Tov A: Localization of the spinal network associated with generation of hindlimb locomotion in the neonatal rat and organization of its transverse coupling system. J Neurophysiol. 1997 Mar;77(3):1155-70.

An alternating rhythm persisted also in preparations that were midsagittally split up to T13-T12, or down to L4.
Bath application of the glycine receptor antagonist strychnine, or the gamma-aminobutyric acid-A (GABAA) receptor blocker bicuculline, induced in the presence of NMDA and 5-HT a bilaterally synchronous rhythm in any intact or detached segment of the cord and in midsagittally split preparations with few bilaterally intact upper thoracic or lower sacral segments.
1(0,0,0,1) Details