| Name | choline acetyltransferase |
|---|---|
| Synonyms | CHAT; CHOACTase; CLAT; CMS1A; CMS1A2; ChAT; Choline O acetyltransferase; Choline acetylase… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10683407 | Darstein M, Landwehrmeyer GB, Kling C, Becker CM, Feuerstein TJ: Strychnine-sensitive glycine receptors in rat caudatoputamen are expressed by cholinergic interneurons. Neuroscience. 2000;96(1):33-9. Fluorescent dual labelling demonstrated that glycine receptor-like immunoreactivity co-localizes with choline acetyltransferase-like immunoreactivity in rat caudatoputamen. |
2(0,0,0,2) | Details |
| 9551830 | Shefchyk SJ, Espey MJ, Carr P, Nance D, Sawchuk M, Buss R: Evidence for a strychnine-sensitive mechanism and glycine receptors involved in the control of urethral sphincter activity during micturition in the cat. Exp Brain Res. 1998 Apr;119(3):297-306. Motoneurons in Onufs nucleus in S1 were identified using choline acetyltransferase immunohistochemistry and subsequently processed with a gephyrin monoclonal antibody. |
1(0,0,0,1) | Details |
| 11160606 | Ferreira M, Ebert SN, Perry DC, Yasuda RP, Baker CM, Davila-Garcia MI, Kellar KJ, Gillis RA: Evidence of a functional alpha7-neuronal nicotinic receptor subtype located on motoneurons of the dorsal motor nucleus of the vagus. J Pharmacol Exp Ther. 2001 Feb;296(2):260-9. Simultaneous staining of rat brainstem sections with anti-alpha7 and anti-choline acetyltransferase (ChAT) antibodies (to identify cholinergic DMV neurons that project into the vagus nerve) revealed that every DMV neuron that was stained for ChAT showed alpha7-staining as well. To test whether the alpha7-nAChR is similar to the alpha7-homomeric nAChR, experiments were performed in anesthetized rats, and compounds were microinjected into the DMV while monitoring intragastric pressure (IGP). alpha-BGTx and strychnine antagonized -induced increases in IGP; no antagonism was observed with methyllycaconitine, a compound known to block the homomeric alpha7-nAChR subtype. |
1(0,0,0,1) | Details |
| 18550725 | Quinlan KA, Buchanan JT: Cellular and synaptic actions of in the lamprey spinal cord. . J Neurophysiol. 2008 Aug;100(2):1020-31. Epub 2008 Jun 11. Immunohistochemistry for choline acetyltransferase, performed in combination with retrograde filling of motoneurons, demonstrated a population of nonmotoneuron cholinergic cells in the lamprey spinal cord. Hyperpolarizing potentials were also observed and were attenuated by the glycinergic antagonist strychnine, whereas depolarizing responses were potentiated by strychnine. |
1(0,0,0,1) | Details |
| 11691868 | Neunlist M, Michel K, Reiche D, Dobreva G, Huber K, Schemann M: activates myenteric neurones in adult guinea-pigs. J Physiol. 2001 Nov 1;536(Pt 3):727-39. Most -sensitive neurones had ascending projections and were choline acetyltransferase immunoreactive. Strychnine (300 nM) reversibly abolished the -induced depolarisation and the Cl (-) channel blocker picrotoxin (100 microM) reduced the amplitude of the depolarisation by 55 +/- 5 %. |
1(0,0,0,1) | Details |