| Name | NMDA receptor (protein family or complex) |
|---|---|
| Synonyms | Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10191715 | Hewkin CT, Di Fabio R, Conti N, Cugola A, Gastaldi P, Micheli F, Quaglia AM: New synthesis of substituted derivatives: versatile introduction of a carbamoylethynyl moiety at the C-3 position. Arch Pharm. 1999 Feb;332(2):55-8. A novel series of 3-carbamoylethynyl-2-carboxyindoles, antagonists acting at the strychnine-insensitive binding site associated with the NMDA receptor, has been synthesised. |
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| 8101466 | Zidichouski JA, Jhamandas JH: Electrophysiological characterization of excitatory amino acid responses in rat lateral parabrachial neurons in vitro. Brain Res. 1993 May 21;611(2):313-21. The allosteric modulation of the NMDA receptor by the strychnine-insensitive binding site was examined by the application of the amino acid (0.5 mM). |
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| 8996180 | Witkin JM, Steele TD, Sharpe LG: Effects of strychnine-insensitive glycine receptor ligands in rats discriminating dizocilpine or phencyclidine from saline. J Pharmacol Exp Ther. 1997 Jan;280(1):46-52. acts as a co-agonist for activation of the NMDA receptor complex through a strychnine-insensitive receptor, which is a potential target for novel therapeutic agents (e.g., anticonvulsants, antidepressants). |
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| 9838131 | Kawabe K, Yoshihara T, Ichitani Y, Iwasaki T: Intrahippocampal D-cycloserine improves MK-801-induced memory deficits: radial-arm maze performance in rats. Brain Res. 1998 Dec 14;814(1-2):226-30. In order to investigate whether strychnine-insensitive sites coupled with hippocampal (N-methyl-d-aspartate) receptors are involved in spatial memory in rats, we examined the effects of intrahippocampal treatment of d-cycloserine (DCS), a -site agonist, on spatial-memory deficits which were produced by an antagonist MK-801 (dizocilpine) on the radial-arm maze task. |
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| 9384243 | Mennini T, Mancini L, Reggiani A, Trist D: GV 150526A, 7-Cl- and HA 966 antagonize the enhancement of -induced [3H] and [3H] release. Eur J Pharmacol. 1997 Oct 8;336(2-3):275-81. The nanomolar potency of GV 150526A in reducing NMDA receptor function by competitively acting at the strychnine-insensitive sites suggests that GV 150526A could be effective in vivo to reduce NMDA receptor over-stimulation, like in brain ischemia. |
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| 7912632 | Shuker MA, Bowser-Riley F, Davies SN: Possible antagonist properties of drugs that affect high pressure neurological syndrome. Br J Pharmacol. 1994 Mar;111(3):951-5. We have now used the rat hippocampal slice preparation to examine the possibility that some of these drugs might instead have an action at the strychnine-insensitive (SI) binding site associated with the NMDA receptor. 2. |
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| 12352624 | Miyakawa N, Uchino S, Yamashita T, Okada H, Nakamura T, Kaminogawa S, Miyamoto Y, Hisatsune T: A glycine receptor antagonist, strychnine, blocked NMDA receptor activation in the neonatal mouse neocortex. Neuroreport. 2002 Sep 16;13(13):1667-73. |
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| 9579291 | Deutsch SI, Rosse RB, Mastropaolo J: Current status of antagonist interventions in the treatment of nonketotic hyperglycinemia. Clin Neuropharmacol. 1998 Mar-Apr;21(2):71-9. However, the recent recognition of a "strychnine-insensitive" binding site for on the (NMDA) receptor complex, -gated cationic channel, has led to some newer approaches. |
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| 7635092 | Guillet R, Dunham L: Neonatal exposure and seizure susceptibility in adult rats. Epilepsia. 1995 Aug;36(8):743-9. At age 70-90 days, each rat was infused intravenously (i.v.) with picrotoxin (PIC), bicuculline (BIC) [convulsants acting at the /benzodiazepine (GABA/BDZ) receptor], pentylenetetrazol [PTZ, possibly acting at both /BDZ and (NMDA) receptors], (acting at receptors), strychnine (STR, acting at glycine receptors), or kainic acid (KA, acting at the NMDA receptor). |
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| 9895039 | Kostowski W, Bienkowski P: Discriminative stimulus effects of neuropharmacological characterization. Alcohol. 1999 Jan;17(1):63-80. Further, some antagonists of strychnine-insensitive modulatory sites among the NMDA receptor complex (e.g., L-701,324) dose-dependently substitute for the discriminative stimulus. |
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| 9792190 | Nagata Y, Uehara T, Kitamura Y, Nomura Y, Horiike K: content and D-[3H] serine binding in the brain regions of the senescence-accelerated mouse. Mech Ageing Dev. 1998 Aug 14;104(2):115-24. binds to strychnine-insensitive binding sites of the (NMDA) receptor complex, and enhances binding to the receptor complex. |
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| 15235081 | Bradaia A, Schlichter R, Trouslard J: Role of glial and neuronal transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J Physiol. 2004 Aug 15;559(Pt 1):169-86. Epub 2004 Jul 2. In the presence of strychnine, bicuculline and CNQX, we recorded electrically evoked NMDA receptor-mediated EPSCs (eEPSCs). eEPSCs were suppressed by 30 micromd-2-amino-5-phosphonovalerate (APV), an antagonist of the NMDA receptor, and by 30 microm dichlorokynurenic acid (DCKA), an antagonist of the site of the NMDA receptor. |
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| 9007841 | Fedele E, Bisaglia M, Raiteri M: modulates the NMDA receptor/nitric oxide/cGMP pathway in the rat cerebellum during in vivo microdialysis. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jan;355(1):43-7. These data show that in vivo the activation of the strychnine-insensitive site is essential for the functioning of the NMDA receptor complex and can be activated by the selective agonist |
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| 11139828 | Tranquillini ME, Reggiani A: -site antagonists and stroke. . Expert Opin Investig Drugs. 1999 Nov;8(11):1837-1848. This review focuses on the strychnine insensitive binding site located on the NMDA receptor channel, and on the possible use of selective antagonists for the treatment of stroke. |
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| 8384115 | McAllister KH: Antagonism of non-NMDA receptors inhibits handling-induced, strychnine-potentiated convulsions. Eur J Pharmacol. 1993 Feb 9;231(2):309-12. |
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| 7952857 | Hunter JC, Atwal P, Woodruff GN, Singh L: Differential modulation of kappa and mu opioid antinociception by the /NMDA receptor agonist Br J Pharmacol. 1994 Aug;112(4):1002-3. a selective agonist for the strychnine-insensitive allosteric site associated with the NMDA receptor-ion channel complex, was found to modulate differentially the antinociception produced by kappa and mu-opioid receptor agonists in the rat formalin test. |
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| 8248282 | Stone TW: Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev. 1993 Sep;45(3):309-79. The pathway includes two compounds, and which are remarkably specific in their pharmacological profiles: one is a selective agonist at receptors sensitive to whereas the other is a selective antagonist at low concentrations at the strychnine-resistant modulatory site associated with the NMDA receptor. |
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| 10847554 | Nowak G, Li Y, Paul IA: Chronic treatment desensitizes the behavioral response to 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at the strychnine-insensitive site of the NMDA receptor complex. J Neural Transm. 2000;107(2):123-31. |
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| 8997600 | Papp M, Moryl E, Maccecchini ML: Differential effects of agents acting at various sites of the NMDA receptor complex in a place preference conditioning model. Eur J Pharmacol. 1996 Dec 19;317(2-3):191-6. A conditioned place preference paradigm was used to assess the potential rewarding properties of the uncompetitive NMDA receptor antagonist, MK-801 (dizolcipine), the two competitive NMDA receptor antagonists, CGP 37849 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentonoic acid) and its (R)-enantiomer CGP 40116, as well as the partial agonist at strychnine-insensitive glycine receptors, ACPC (1-aminocyclopropanecarboxylic acid). |
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| 9157329 | Sato K, Momose-Sato Y, Hirota A, Sakai T, Kamino K: Optical studies of the biphasic modulatory effects of on excitatory postsynaptic potentials in the chick brainstem and their embryogenesis. Neuroscience. 1996 Jun;72(3):833-46. The enhancing effect was insensitive to strychnine, but the reducing effect was blocked by strychnine, suggesting that the former effect was induced by which increased binding to N-methyl-D-aspartate receptors, and the latter resulted from an increase in conductance through the strychnine-sensitive inhibitory glycine receptors in postsynaptic neurons. |
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| 8000442 | Maj J, Rogoz Z, Skuza G, Kolodziejczyk K: Some central effects of 7-chlorokynurenic acid and 5,7- dichloro- site antagonists. Pol J Pharmacol. 1994 May-Jun;46(3):115-24. Strychnine-insensitive site is one of a few binding sites of NMDA receptor complex. |
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| 12930797 | Kinney GG, Sur C, Burno M, Mallorga PJ, Williams JB, Figueroa DJ, Wittmann M, Lemaire W, Conn PJ: The transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy) propyl] potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci. 2003 Aug 20;23(20):7586-91. acts as a necessary coagonist for at the NMDA receptor (NMDAR) complex by binding to the strychnine-insensitive -B binding site on the NR1 subunit. |
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| 7582120 | Hashimoto A, Oka T, Nishikawa T: Anatomical distribution and postnatal changes in endogenous free D- and in rat brain and periphery. Eur J Neurosci. 1995 Aug 1;7(8):1657-63. Because potentiates N-methyl-D-aspartate receptor-mediated transmission through the strychnine-insensitive site and because exhibits an N-methyl-D- receptor-related distribution and development, may be a tenable candidate for an intrinsic ligand for the site. |
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| 8233055 | Biella G, Lacerenza M, Marchettini P, Sotgiu ML: Diverse modulation by systemic lidocaine of iontophoretic and quisqualic acid induced excitations on rat dorsal horn neurons. Neurosci Lett. 1993 Jul 23;157(2):207-10. The results show that lidocaine induced (i) potentiation of the excitation, reversible by 7-chloro- (7-Cl-KYNA), a selective antagonist of the binding site on the NMDA receptor; (ii) reduction of the QUIS excitation, reversible by strychnine (STRYCH), a antagonist at its receptor. |
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| 9707286 | Lingenhohl K, Pozza MF: Reevaluation of ACEA 1021 as an antagonist at the strychnine-insensitive site of the N-methyl-D-aspartate receptor. Neuropharmacology. 1998 Jun;37(6):729-37. |
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| 9651880 | Mugnaini M, Antolini M, Corsi M, van Amsterdam FT: [3H] 5,7-dichlorokynurenic acid recognizes two binding sites in rat cerebral cortex membranes. J Recept Signal Transduct Res. 1998 Mar-May;18(2-3):91-112. Binding of [3H] 5,7-dichlorokynurenic acid ([3H] DCKA), a competitive antagonist of the strychnine-insensitive site of the (NMDA) receptor channel complex, was characterized in synaptic plasma membranes from rat cerebral cortex. |
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| 8531091 | Witkin JM, Brave S, French D, Geter-Douglass B: Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther. 1995 Dec;275(3):1267-73. |
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| 8508908 | Fletcher EJ, MacDonald JF: Haloperidol interacts with the strychnine-insensitive site at the NMDA receptor in cultured mouse hippocampal neurones. Eur J Pharmacol. 1993 Apr 28;235(2-3):291-5. |
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| 7566501 | Allen CN, Omelchenko I, Ross SM, Spencer P: The neurotoxin, beta-N-methylamino- (BMAA) interacts with the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. Neuropharmacology. 1995 Jun;34(6):651-8. Electrophysiological and receptor binding techniques were used to determine whether the neurotoxin beta-N-methylamino- (BMAA), a monocarboxylic amino acid, can act at the strychnine-insensitive modulatory site to modify the activity of N-methyl-D-aspartate receptors. |
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| 9294970 | Lanza M, Bonnafous C, Colombo S, Revel L, Makovec F: Characterization of a novel putative cognition enhancer mediating facilitation of effect on strychnine-resistant sites coupled to NMDA receptor complex. Neuropharmacology. 1997 Aug;36(8):1057-64. |
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| 9106910 | Kretschmer BD, Koch M: Role of the strychnine-insensitive binding site in the nucleus accumbens and anterodorsal striatum in sensorimotor gating: a behavioral and microdialysis study. Psychopharmacology. 1997 Mar;130(2):131-8. This study examined the role of the strychnine-insensitive binding site of the NMDA receptor in prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. |
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| 9181635 | Riekkinen M, Kemppainen S, Riekkinen P Jr: Effects of stimulation of alpha 1-adrenergic and /-B receptors on learning defects in aged rats. Psychopharmacology. 1997 May;131(1):49-56. The present study was designed to investigate the efficacy of stimulation of alpha1-adrenoceptors and the strychnine insensitive -B binding sites of the (NMDA) receptor complex to alleviate the age-related defect in water maze (WM) spatial (hidden platform) navigation. |
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| 7472439 | Randic M, Cheng G, Kojic L: kappa-opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord. J Neurosci. 1995 Oct;15(10):6809-26. Monosynaptic and polysynaptic excitatory postsynaptic potentials (EPSPs) were evoked by orthodromic electrical stimulation of A delta or C primary afferent fibers in the dorsal root after blocking inhibitory inputs with bicuculline and strychnine, NMDA receptors with D-2-amino-5-phosphonovaleric acid and mu- and delta-opioid receptors with CTAP and ICI 174,864, respectively. |
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| 9144639 | Przegalinski E, Tatarczynska E, Deren-Wesolek A, Chojnacka-Wojcik E: Antidepressant-like effects of a partial agonist at strychnine-insensitive glycine receptors and a competitive NMDA receptor antagonist. Neuropharmacology. 1997 Jan;36(1):31-7. |
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| 8728541 | Przegalinski E, Tatarczynska E, Deren-Wesolek A, Chojnacka-Wojcik E: Anticonflict effects of a competitive NMDA receptor antagonist and a partial agonist at strychnine-insensitive glycine receptors. Pharmacol Biochem Behav. 1996 May;54(1):73-7. |
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| 11343602 | Heresco-Levy U: (NMDA) receptor-based treatment approaches in schizophrenia: the first decade. Int J Neuropsychopharmacol. 2000 Sep;3(3):243-258. Moreover, the antipsychotic action of some typical and atypical neuroleptics may be mediated by their agonistic activity at the strychnine-insensitive NMDA receptor-associated Gly site. |
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| 9247969 | Hashimoto A, Oka T: Free D- and in the mammalian brain and periphery. Prog Neurobiol. 1997 Jul;52(4):325-53. Since D-aspartate and have been shown to potentiate NMDA receptor-mediated transmission through the binding site and the strychnine-insensitive binding site, respectively, and have been utilized extensively as potent and selective tools to study the excitatory amino acid system in the brain, we shall discuss also the NMDA receptor and uptake system of D-amino acids. |
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| 8098640 | Parsons CG, Zong X, Lux HD: Whole cell and single channel analysis of the kinetics of -sensitive N-methyl-D-aspartate receptor desensitization. Br J Pharmacol. 1993 May;109(1):213-21. The desensitization was due to a decrease in the affinity of for the strychnine-insensitive, modulatory site (glycineB site) following activation of the NMDA-receptor complex. |
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| 16026768 | Xie X, Dumas T, Tang L, Brennan T, Reeder T, Thomas W, Klein RD, Flores J, O'Hara BF, Heller HC, Franken P: Lack of the -serine- transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Res. 2005 Aug 9;1052(2):212-21. Asc-1 transports small neutral amino acids with high affinity especially for and (K (i): 8-12 microM), two endogenous co-agonists that activate (NMDA) receptors through interacting with the strychnine-insensitive binding-site. |
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| 9498236 | Hantzschel A, Andreas K: Efficacy of glutamate receptor antagonists in the management of functional disorders in cytotoxic brain oedema induced by hexachlorophene. Pharmacol Toxicol. 1998 Feb;82(2):80-8. Similar effects were observed with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the dose of 0.8 mg/kg intraperitoneally, an antagonist interacting both with the strychnine-insensitive binding site for within the NMDA receptor complex and with the kainate (+/-)-alpha-amino-3--5-methylisoxazole-4- (AMPA) receptor complex. |
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| 9892253 | Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Silipo G, Lichtenstein M: Efficacy of high-dose in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 1999 Jan;56(1):29-36. a small nonessential amino acid, functions as an obligatory coagonist at NMDA receptors through its action at a strychnine-insensitive binding site on the NMDA receptor complex. |
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| 9313270 | Khandwala H, Hodge E, Loomis CW: Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat. Pain. 1997 Sep;72(3):299-308. The data indicate that: (i) robust allodynia can be selectively induced with i.t. strychnine in animals whose somatosensory systems are otherwise normal; (ii) sub-anesthetic doses of i.v. mexiletine inhibit the abnormal responses to low-threshold (A-fiber) afferent input in the strychnine model of allodynia (i.e., in the absence of peripheral or central nerve injury) at doses which affect normal nociception; and (iii) in the presence of i.t. strychnine, low-threshold afferent input activates a spinal NMDA-receptor mediated process normally restricted to noxious afferent input. |
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| 11698028 | Parsons CG: NMDA receptors as targets for drug action in neuropathic pain. Eur J Pharmacol. 2001 Oct 19;429(1-3):71-8. Functional inhibition of NMDA receptors can be achieved through actions at different recognition sites such as the primary transmitter site (competitive), strychnine-insensitive site (B)), polyamine site (NR2B selective) and phencyclidine site located inside the cationic channel. |
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| 10852232 | Bardoni R, Magherini PC, MacDermott AB: Activation of NMDA receptors drives action potentials in superficial dorsal horn from neonatal rats. Neuroreport. 2000 Jun 5;11(8):1721-7. This NMDA receptor-mediated activity was enhanced when bicuculline and strychnine were used to block synaptic inhibition. |
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| 15523521 | Lavrov I, Cheng J: Activation of NMDA receptors is required for the initiation and maintenance of walking-like activity in the mudpuppy (Necturus Maculatus). Can J Physiol Pharmacol. 2004 Aug-Sep;82(8-9):637-44. Only at concentration as high as 100 micromol/L, did CNQX cause complete block of the rhythmic activity, presumably through nonspecific action on the strychnine-insensitive site of NMDA receptors. |
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| 8788421 | Wiley JL, Cristello AF, Balster RL: Effects of site-selective NMDA receptor antagonists in an elevated plus-maze model of anxiety in mice. Eur J Pharmacol. 1995 Dec 27;294(1):101-7. These compounds bind to several specific sites within the NMDA-receptor complex, including the site itself, the phencyclidine site, and the strychnine-insensitive site. |
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| 9758163 | Paudice P, Gemignani A, Raiteri M: Evidence for functional native NMDA receptors activated by or alone in the absence of glutamatergic coagonist. Eur J Neurosci. 1998 Sep;10(9):2934-44. This effect of was strychnine-insensitive and could be mimicked by a stereoselective agonist at the NMDA receptor site. |
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| 9526557 | Balsamini C, Bedini A, Diamantini G, Spadoni G, Tontini A, Tarzia G, Di Fabio R, Feriani A, Reggiani A, Tedesco G, Valigi R: (E)-3-(2-(N-phenylcarbamoyl) vinyl) derivatives. J Med Chem. 1998 Mar 12;41(6):808-20. These compounds were studied for their in vitro affinity at the strychnine-insensitive -binding site of the (NMDA) receptor complex. |
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| 16457470 | Zielinska E, Kocki T, Saran T, Borbely S, Kuc D, Vilagi I, Urbanska EM, Turski WA: Effect of pesticides on production in rat brain slices. Ann Agric Environ Med. 2005;12(2):177-9. (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive allosteric site of the (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor. |
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| 15688094 | Javitt DC, Hashim A, Sershen H: Modulation of striatal release by transport inhibitors. . Neuropsychopharmacology. 2005 Apr;30(4):649-56. NMDA receptors in brain are regulated by acting via a strychnine-insensitive regulatory site, and by (GlyT1) transporters that maintain low levels in the immediate vicinity of the NMDA receptor complex. |
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| 8728878 | Wikinski SI, Acosta GB: [Role of excitatory amino acids in neuropathology] . Medicina (B Aires). 1995;55(4):355-65. MK801 or AP5) prevent the development of epileptic seizures induced by kindling; CNQX, an AMPA antagonist, blocks the increase in electrical activity induced by K+ in slices of hypocampus; felbamate, an antiepileptic drug, blocks the site (not strychnine sensitive) decreasing NMDA receptor activity. |
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| 10344778 | Biala G, Kotlinska J: Blockade of the acquisition of -induced conditioned place preference by N-methyl-D-aspartate receptor antagonists. Alcohol Alcohol. 1999 Mar-Apr;34(2):175-82. Both dizocilpine (0.1 mg/kg, i.p.), a non-competitive antagonist of the NMDA receptor, and L-701,324 (5 mg/kg, per os), an antagonist acting at the strychnine-insensitive site of NMDA receptor complex, when co-administered repeatedly with prevented the acquisition of ethanol-induced CPP. |
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| 8848014 | Fossom LH, Basile AS, Skolnick P: Sustained exposure to 1-aminocyclopropanecarboxylic acid, a partial agonist, alters N-methyl-D-aspartate receptor function and subunit composition. Mol Pharmacol. 1995 Dec;48(6):981-7. Partial agonists at the strychnine-insensitive sites coupled to (NMDA) receptors reduce both -induced neurotoxicity in vitro and ischemia-induced neurodegeneration in vivo. |
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| 19890609 | Krueger BA, Weil T, Schneider G: Comparative virtual screening and novelty detection for -GlycineB antagonists. J Comput Aided Mol Des. 2009 Dec;23(12):869-81. Epub 2009 Nov 5. We validated and successfully applied different state-of-the-art techniques for virtual screening (Bayesian machine learning, automated molecular docking, pharmacophore search, pharmacophore QSAR and shape analysis) of 4.6 million unique and readily available chemical structures to identify promising new and competitive antagonists of the strychnine-insensitive binding site (B) site) of the NMDA receptor. |
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| 8773787 | Milne B, Duggan S, Jhamandas K, Loomis C: Innocuous hair deflection evokes a nociceptive-like activation of oxidation in the rat locus coeruleus following intrathecal strychnine: a biochemical index of allodynia using in vivo voltammetry. Brain Res. 1996 Apr 29;718(1-2):198-202. This effect on the LC is: (1) comparable to that observed with noxious stimulation without i.t. strychnine; (2) segmentally localized, corresponding to the spinal site of strychnine injection; and (3) mediated by spinal NMDA receptors, consistent with the role of excitatory amino acids in sensory transmission. |
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| 18805436 | Yang CR, Svensson KA: Allosteric modulation of NMDA receptor via elevation of brain and the therapeutic potentials for schizophrenia. Pharmacol Ther. 2008 Dec;120(3):317-32. Epub 2008 Aug 27. Endogenous and both act as co-agonists on the strychnine-insensitive GlyB site on the NMDA receptor, and along with co-activate the NMDA receptor. |
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| 8768744 | Matsuoka N, Aigner TG: D-cycloserine, a partial agonist at the site coupled to N-methyl-D-aspartate receptors, improves visual recognition memory in rhesus monkeys. J Pharmacol Exp Ther. 1996 Aug;278(2):891-7. Strychnine-insensitive binding sites have recently been shown to positively modulate (NMDA) receptors. |
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| 7909453 | Ishimaru M, Kurumaji A, Toru M: Increases in strychnine-insensitive binding sites in cerebral cortex of chronic schizophrenics: evidence for hypothesis. Biol Psychiatry. 1994 Jan 15;35(2):84-95. Strychnine-insensitive binding sites, an absolute requirement of the responses mediated by (NMDA) receptors, were measured in the postmortem brains of 13 chronic schizophrenics and 10 controls, using a radiolabeled receptor assay. |
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| 14770276 | Wejksza K, Rzeski W, Parada-Turska J, Zdzisinska B, Rejdak R, Kocki T, Okuno E, Kandefer-Szerszen M, Zrenner E, Turski WA: production in cultured bovine aortic endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Mar;369(3):300-4. Epub 2004 Feb 10. (KYNA) is a broad-spectrum antagonist at all subtypes of ionotropic glutamate receptors, but is preferentially active at the strychnine-insensitive allosteric site of the (NMDA) receptor and is also a non-competitive antagonist at the alpha7 nicotinic receptor. |
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| 8096423 | Boje KM, Wong G, Skolnick P: Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures. Brain Res. 1993 Feb 19;603(2):207-14. These effects may represent homologous desensitization of the NMDA receptor complex at its strychnine-insensitive glycine receptor induced by prolonged exposure to glycinergic agonists and partial agonists. |
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| 10604951 | Snell LD, Claffey DJ, Ruth JA, Valenzuela CF, Cardoso R, Wang Z, Levinson SR, Sather WA, Williamson AV, Ingersoll NC, Ovchinnikova L, Bhave SV, Hoffman PL, Tabakoff B: Novel structure having antagonist actions at both the site of the N-methyl-D-aspartate receptor and neuronal voltage-sensitive channels: biochemical, electrophysiological, and behavioral characterization. J Pharmacol Exp Ther. 2000 Jan;292(1):215-27. These compounds were shown to act in a use-dependent manner as antagonists of VSNaCs and to act as selective competitive antagonists at the strychnine-insensitive recognition site of NMDA receptors. |
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| 9459010 | Micheli F, Cugola A, Donati D, Missio A, Pecunioso A, Reggiani A, Tarzia G: 2,3-Dihydro-6,7-dichloro-pyrido [2,3-b] pyrazine-8-oxide as selective antagonist with in vivo activity. Bioorg Med Chem. 1997 Dec;5(12):2129-32. 2,3-Dihydro-6,7-dichloro-pyrido [2,3-b] pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of antagonists in vivo. |
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| 12932897 | Jansen M, Dannhardt G: Antagonists and agonists at the site of the NMDA receptor for therapeutic interventions. Eur J Med Chem. 2003 Jul-Aug;38(7-8):661-70. Contrary to the inhibitory glycine receptor (A)) the binding site on the NMDA receptor (B)) is strychnine-insensitive. |
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| 9572287 | Pearlstein RD, Beirne JP, Massey GW, Warner DS: Neuroprotective effects of NMDA receptor recognition site antagonism: dependence on concentration. J Neurochem. 1998 May;70(5):2012-9. The effects of and ACEA 1021 on -induced LDH release were consistent with a model of simple competitive interaction for the strychnine-insensitive NMDA receptor recognition site, although nonspecific effects at the kainate receptor may be of lesser importance. |
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| 7834343 | Ball EF, Shaw PJ, Ince PG, Johnson M: The distribution of excitatory amino acid receptors in the normal human midbrain and basal ganglia with implications for Parkinson's disease: a quantitative autoradiographic study using [3H] MK-801, [3H] [3H] CNQX and [3H] kainate. Brain Res. 1994 Sep 26;658(1-2):209-18. In the substantia nigra relatively high densities of [3H] MK-801 and strychnine-insensitive [3H] binding sites representing NMDA receptors were present, whereas only moderate densities of [3H] CNQX and [3H] kainate binding sites were present, compared to other regions. |
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| 8104234 | Mugnaini M, Giberti A, Ratti E, van Amsterdam FT: Allosteric modulation of [3H] CGP 39653 binding by in rat brain. . J Neurochem. 1993 Oct;61(4):1492-7. another agonist at the strychnine-insensitive binding site of the NMDA receptor complex, inhibits [3H] CGP 39653 binding in the same way as with a potency that correlates with its binding affinity at the site. |
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| 11896173 | Walker DL, Ressler KJ, Lu KT, Davis M: Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J Neurosci. 2002 Mar 15;22(6):2343-51. Here we evaluate the ability of D-cycloserine (DCS), a partial agonist at the strychnine-insensitive -recognition site on the NMDA receptor complex, to facilitate conditioned fear extinction after systemic administration or intra-amygdala infusions. |
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| 10919080 | Tedesco G, Feriani A, Mor M: Statistical analysis on a series of antagonists. . Farmaco. 2000 Mar;55(3):194-6. The effect of substitution on the heteroaromatic ring was investigated with the aim of further improving the affinity (expressed as pKi) of these derivatives towards the strychnine-insensitive binding site associated with the NMDA receptor. |
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| 9092952 | White HS: Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia. 1997;38 Suppl 1:S9-17. FBM appears to be active at the strychnine-insensitive binding site of the NMDA receptor. |
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| 15548203 | Pierobon P, Sogliano C, Minei R, Tino A, Porcu P, Marino G, Tortiglione C, Concas A: Putative NMDA receptors in Hydra: a biochemical and functional study. Eur J Neurosci. 2004 Nov;20(10):2598-604. Simultaneous administration of ineffective doses of and strychnine, or an agonist at the binding site of the NMDA receptor in vertebrate CNS, resulted in a strong reduction of response duration. |
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| 7830087 | Nowak G, Redmond A, McNamara M, Paul IA: Swim stress increases the potency of at the N-methyl-D-aspartate receptor complex. J Neurochem. 1995 Feb;64(2):925-7. We have previously demonstrated that chronic administration of antidepressants results in a reduction in the potency of to displace 5,7-[3H] dichlorokynurenic acid (5,7-[3H]-DCKA) from the strychnine-insensitive recognition site of the NMDA receptor complex. |
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| 8265681 | Namba T, Morimoto K, Yamada N, Otsuki S: Antiepileptogenic action of 7-chlorokynurenic acid on amygdala kindling of rats. Pharmacol Biochem Behav. 1993 Oct;46(2):275-81. These results demonstrate that this selective strychnine-insensitive glycine receptor antagonist has antiepileptogenic activity and suggest a role for the glycine receptors in the contribution of the NMDA receptor complex to epileptogenic events. |
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| 8046463 | Glaum SR, Miller RJ, Hammond DL: Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord. J Neurosci. 1994 Aug;14(8):4965-71. Excitatory postsynaptic currents (EPSCs) or potentials (EPSPs) were evoked electrically at the ipsilateral dorsal root entry zone after blocking inhibitory inputs with bicuculline and strychnine, and NMDA receptors with D-2-amino-5-phosphonopentanoic acid. |
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| 7537613 | Musshoff U, Madeja M, Bloms-Funke P, Speckmann EJ: Effects of the epileptogenic agent strychnine on membrane currents elicited by agonists of the and non-NMDA receptors in Xenopus oocytes. Comp Biochem Physiol A Physiol. 1995 May;111(1):65-71. |
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| 7905831 | Paul IA, Layer RT, Skolnick P, Nowak G: Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or Eur J Pharmacol. 1993 Nov 15;247(3):305-11. These changes were manifested as: (1) a reduction in the potency of to inhibit the binding of 5,7-dichloro [3H] to strychnine-insensitive glycine receptors; and (2) a reduction in the proportion of high affinity, -displaceable [3H] CGP-39653 binding to NMDA receptors. |
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| 16455236 | Martineau M, Baux G, Mothet JP: Gliotransmission at central glutamatergic synapses: on stage. J Physiol Paris. 2006 Mar-May;99(2-3):103-10. Epub 2006 Feb 7. This molecule synthesized through racemization of fulfils most criteria as a gliotransmitter and as the endogenous ligand for the strychnine-insensitive binding site of the NMDA receptors. |
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| 8801339 | Cherkofsky SC: 1-Aminocyclopropanecarboxylic acid: mouse to man interspecies pharmacokinetic comparisons and allometric relationships. J Pharm Sci. 1995 Oct;84(10):1231-5. 1-Aminocyclopropanecarboxylic acid (ACPC) is a partial agonist at the strychnine-insensitive recognition site on the (NMDA) receptor complex in the mammalian central nervous system with preclinical activity in animal models of neuroprotection and psychiatric illnesses. |
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| 7917183 | Vamvakides A: [Nootropic activity of glycinergic derivatives in relation to their dualistic effects on cerebral monoamines]. Boll Chim Farm. 1994 Jun;133(6):369-73. Indeed, at a low dose of a glycinergic compound, the nootropic effects could principally result from the inhibition of the monoaminergic systems, by the effect of the glycinergic agonist on the strychnine sensitive receptors, while its action on the NMDA receptors could only operate to support the response of the latter. |
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| 10218865 | Wlaz P, Ebert U, Loscher W: Anticonvulsant effects of eliprodil alone or combined with the glycineB receptor antagonist L-701,324 or the competitive antagonist CGP 40116 in the amygdala kindling model in rats. Neuropharmacology. 1999 Feb;38(2):243-51. The discovery that glutamate's activity at the (NMDA) receptor is positively modulated by and polyamines has led to a new pharmacological strategy that NMDA receptor-mediated events could be antagonized indirectly at the strychnine-insensitive co-agonist site (B) receptor) and the polyamine modulatory site. |
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| 9694960 | McCabe RT, Sofia RD, Layer RT, Leiner KA, Faull RL, Narang N, Wamsley JK: Felbamate increases [3H] binding in rat brain and sections of human postmortem brain. J Pharmacol Exp Ther. 1998 Aug;286(2):991-9. The anticonvulsant compound felbamate (2-phenyl-1,3- dicarbamate; FBM) appears to inhibit the function of the (NMDA) receptor complex through an interaction with the strychnine-insensitive recognition site. |
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| 17519647 | Storch EA, Merlo LJ, Bengtson M, Murphy TK, Lewis MH, Yang MC, Jacob ML, Larson M, Hirsh A, Fernandez M, Geffken GR, Goodman WK: D-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorder. Int Clin Psychopharmacol. 2007 Jul;22(4):230-7. Recent animal and clinical data suggest that D-cycloserine, a partial agonist that acts at the strychnine-insensitive -recognition site of the N-methyl-D-aspartate receptor complex, may enhance extinction learning that occurs in exposure-based psychotherapies. |
81(1,1,1,1) | Details |
| 8925878 | Nowak G, Li Y, Paul IA: Adaptation of cortical but not hippocampal NMDA receptors after chronic treatment. Eur J Pharmacol. 1996 Jan 4;295(1):75-85. These results support the hypotheses that: (1) the adaptation of strychnine-insensitive recognition sites and the allosteric coupling of the and recognition sites are independently regulated by chronic antidepressant treatment; (2) chronic antidepressant administration induces regionally selective adaptation of the NMDA receptor complex; and (3) antidepressant-induced adaptation of the NMDA receptor complex may be mediated by regionally selective changes in excitatory amino acid concentration. |
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| 8397587 | Nichols AC, Yielding KL: Anticonvulsant activity of antagonists for the -associated binding site. Mol Chem Neuropathol. 1993 Aug;19(3):269-82. Coupled to the (NMDA) receptor-channel complex is a strychnine-insensitive binding site for |
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| 16253803 | Bauer D, Hamacher K, Broer S, Pauleit D, Palm C, Zilles K, Coenen HH, Langen KJ: Preferred stereoselective brain uptake of --a modulator of glutamatergic neurotransmission. Nucl Med Biol. 2005 Nov;32(8):793-7. Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free have been detected in the mammalian brain. has been demonstrated to be an important modulator of glutamatergic neurotransmission and acts as an agonist at the strychnine-insensitive site of N-methyl-d-aspartate receptors. |
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| 8930257 | Straka H, Dieringer N: Uncrossed disynaptic inhibition of second-order vestibular neurons and its interaction with monosynaptic excitation from vestibular nerve afferent fibers in the frog. J Neurophysiol. 1996 Nov;76(5):3087-101. The monosynaptic EPSP of second-order vestibular neurons was mediated in part by and in part by non-NMDA receptors. Disynaptic IPSPs superimposed upon apparently pure EPSPs were revealed by bath application of the glycine receptor antagonist strychnine (0.5-5 microM) or of the -A (GABAA) receptor antagonist bicuculline (0.5-2 microM). |
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| 9356428 | Chiang CY, Hu JW, Sessle BJ: NMDA receptor involvement in neuroplastic changes induced by neonatal treatment in trigeminal nociceptive neurons. J Neurophysiol. 1997 Nov;78(5):2799-803. Administration of 7-chlorokynurenic acid intrathecally (5 microgram/10 microliter), an antagonist of strychnine-insensitive bindin sites on the NMDA receptor, also significantly reduced neuronal RF size and spontaneous activity in CAP rats, but not in CON rats. |
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| 7903188 | Coderre TJ: Potent analgesia induced in rats by combined action at PCP and polyamine recognition sites of the NMDA receptor complex. Eur J Neurosci. 1993 Apr 1;5(4):390-3. The polyamine antagonist ifenprodil, and the strychnine-insensitive antagonists DCQX and 7-chlorokynurenic acid, failed to produce any analgesic effects in either the early or the late phase of the formalin test. |
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| 8946060 | Ozaki S, Yamada T, Iizuka M, Nishimaru H, Kudo N: Development of locomotor activity induced by NMDA receptor activation in the lumbar spinal cord of the rat fetus studied in vitro. Brain Res Dev Brain Res. 1996 Nov 22;97(1):118-25. The rhythmic motor activity in the presence of strychnine was synchronized on both sides at all stages examined. |
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| 17970719 | Issberner JP, Sillar KT: The contribution of the NMDA receptor site to rhythm generation during fictive swimming in Xenopus laevis tadpoles. Eur J Neurosci. 2007 Nov;26(9):2556-64. Epub 2007 Oct 23. (100 microm), another endogenous agonist at this site, triggered similar effects to but only when applied in the presence of strychnine. |
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| 15207356 | Whitehead KJ, Pearce SM, Walker G, Sundaram H, Hill D, Bowery NG: Positive N-methyl-D-aspartate receptor modulation by selective transporter-1 inhibition in the rat dorsal spinal cord in vivo. Neuroscience. 2004;126(2):381-90. Co-administration by reverse dialysis of the selective -R channel blocker MK-801 (0.5 mM) or the selective antagonist of the strychnine-insensitive site, 7-chlorokynurenic acid (1 mM), with Org 24598 (10 microM) did not affect the uptake inhibition-induced increase in efflux, but did significantly attenuate the increase in extracellular |
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| 7887983 | Forray MI, Andres ME, Bustos G, Gysling K: Regulation of endogenous release from the bed nucleus of stria terminalis. Biochem Pharmacol. 1995 Mar 1;49(5):687-92. In the presence of (10 microM), an agonist at the site associated with the NMDA receptor, the effect was significantly higher. However, exhibited a significant effect by itself, suggesting the existence of strychnine-sensitive glycine receptors in vBNST. |
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| 8880937 | Singh L, Field MJ, Ferris P, Hunter JC, Oles RJ, Williams RG, Woodruff GN: The antiepileptic agent possesses anxiolytic-like and antinociceptive actions that are reversed by Psychopharmacology. 1996 Sep;127(1):1-9. has negligible affinity for the strychnine insensitive [3H] binding site. The intracerebroventricular (ICV) administration of the /NMDA receptor agonist dose-dependently (10-100 micrograms/animal) reversed the antinociceptive action of (200 mg/kg, SC). |
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| 11020764 | Cheng G, Kendig JJ: Enflurane directly depresses AMPA and currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. Anesthesiology. 2000 Oct;93(4):1075-84. Block of inhibitory A and glycine receptors by bicuculline (20 micrometer) or strychnine (2 micrometer) or both did not significantly reduce the effects of enflurane on -evoked currents. The EPSCs were isolated pharmacologically into (NMDA) receptor- and non-NMDA receptor-mediated components by using selective antagonists. |
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| 12742643 | Singh JN, Deshpande SB: Involvement of the GABAergic system for Ptychodiscus brevis toxin-induced depression of synaptic transmission elicited in isolated spinal cord from neonatal rats. Brain Res. 2003 Jun 6;974(1-2):243-8. The N-methyl-D-aspartate receptor antagonist, DL-2-amino-5-phosphono- (10 microM), blocked the PbTx-induced depression of MSR and also the enhancement of response by PbTx. A glycine receptor antagonist, strychnine (1 microM), failed to block the depression by the toxin up to 28 microM; however, the depression was attenuated significantly at 84 microM of the toxin. |
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| 16111839 | Chan MH, Lee CC, Chen HH: Effects of toluene on seizures induced by convulsants acting at distinct ligand-gated ion channels. Toxicol Lett. 2006 Jan 25;160(3):179-84. Epub 2005 Aug 18. Mice were pretreated with toluene (100-1000 mg/kg, i.p.) or corn oil followed by a timed intravenous infusion of bicuculline, picrotoxin, or strychnine to induce seizures. These findings support a unique anticonvulsant profile of toluene and suggest that nicotinic and NMDA receptors may be more sensitive than (A) and glycine receptors to toluene exposure in seizure-related neural circuits. |
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| 7477740 | Fossom LH, Von Lubitz DK, Lin RC, Skolnick P: Neuroprotective actions of 1-aminocyclopropanecarboxylic acid (ACPC): a partial agonist at strychnine-insensitive sites. Neurol Res. 1995 Aug;17(4):265-9. Since occupation of these sites appears required for operation of N-methyl-D-aspartate, receptor coupled cation channels, it was hypothesized that a partial agonist could function as an antagonist. |
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| 19359371 | Chapman RJ, Cilia La Corte PF, Asghar AU, King AE: Network-based activity induced by 4-aminopyridine in rat dorsal horn in vitro is mediated by both chemical and electrical synapses. J Physiol. 2009 Jun 1;587(Pt 11):2499-510. Epub 2009 Apr 9. The glycine receptor antagonist strychnine (4 microM) and the (A) receptor antagonist bicuculline (10 microM) diminished and abolished, respectively, field population spiking and both antagonists reduced the power of 4-12 Hz oscillations. |
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| 9829177 | Rodriguez-Contreras A, Calderon F, Lopez-Colome AM: Strychnine-insensitive [3H] binding to synaptosomal membranes from the chick retina. Int J Dev Neurosci. 1998 Aug;16(5):413-21. |
0(0,0,0,0) | Details |
| 11740501 | Ahmadi S, Lippross S, Neuhuber WL, Zeilhofer HU: PGE (2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci. 2002 Jan;5(1):34-40. We identified the inhibitory (strychnine-sensitive) glycine receptor as a specific target of PGE (2). |
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| 7865165 | Cascella NG, Macciardi F, Cavallini C, Smeraldi E: d-cycloserine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label study. J Neural Transm Gen Sect. 1994;95(2):105-11. D-cycloserine, a partial agonist at the strychnine-insensitive site of the NMDA receptor complex, was tested as adjuvant treatment to conventional neuroleptics in chronic schizophrenic volunteers. |
31(0,1,1,1) | Details |
| 8308859 | Salituro FG, Tomlinson RC, Baron BM, Palfreyman MG, McDonald IA: Enzyme-activated antagonists of the strychnine-insensitive /NMDA receptor. J Med Chem. 1994 Feb 4;37(3):334-6. |
31(0,1,1,1) | Details |
| 15790752 | Mueller PJ, Foley CM, Vogl HW, Hay M, Hasser EM: Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors. Am J Physiol Regul Integr Comp Physiol. 2005 Jul;289(1):R198-208. Epub 2005 Mar 24. Microinjection of (0.02-20 mM) failed to mimic sympathoinhibitory responses to L-AP4, even in the presence of the inhibitory antagonist, strychnine (3 mM). |
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| 10675640 | Devau G: induced concentration changes in vestibular type I sensory cells. Hear Res. 2000 Feb;140(1-2):126-36. may also activate the strychnine-sensitive glycine receptor-gated channel. This calyx may also be involved in local feedback, which may modify sensory cell activity via (NMDA) receptors. |
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| 9200726 | Aroniadou-Anderjaska V, Ennis M, Shipley MT: Glomerular synaptic responses to olfactory nerve input in rat olfactory bulb slices. Neuroscience. 1997 Jul;79(2):425-34. In the rat olfactory bulb, activation of the olfactory nerve evokes a kainate/AMPA receptor-mediated response in the distal, apical dendrites of mitral/tufted cells, followed by a slow N-methyl-D-aspartate receptor-mediated response which triggers prolonged discharge of mitral cells. Strychnine, an antagonist of glycine receptors, had similar effects to those of bicuculline, but only at high concentrations that have been previously shown to block (A) receptors; at low concentrations strychnine had no effect. |
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| 8590073 | Velisek L, Roztocilova L, Kusa R, Mares P: Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis: III. Brain Res Bull. 1995;38(6):525-9. (NMDA) receptor antagonists are anticonvulsant drugs with specific activity against tonic-clonic pentylenetetrazol-induced seizures. In these experiments, we tested the anticonvulsant activity of strychnine-insensitive glycine receptor (at the site) antagonist and nonspecific excitatory amino acid receptor antagonist glutamic acid diethylester (GDEE) in the pentylenetetrazol-induced seizure model in developing rats 7, 12, 18, 25, and 90 days old. |
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| 8725598 | Ishikawa T, Yaksh TL: [Concurrent characterization of spinal amino acid release and touch-evoked allodynia produced by spinal or GABAA receptor antagonists]. Masui. 1996 Apr;45(4):439-44. BACKGROUND: Previous work has shown that spinal strychinine (STR; antagonist) or bicuculline (BIC; GABAA antagonist) yields a touch-evoked allodynia (TEA) that was blocked by NMDA receptor antagonists and that spinal NMDA receptor activation evokes release. |
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| 10587285 | File SE, Fluck E, Fernandes C: Beneficial effects of (bioglycin) on memory and attention in young and middle-aged adults. J Clin Psychopharmacol. 1999 Dec;19(6):506-12. The N-methyl D-aspartate receptor complex is involved in the mechanism of long-term potentiation, which is thought to be the biological basis of learning and memory. This complex can be manipulated in a number of ways, one of which is through the strychnine-insensitive glycine receptor coagonist site. |
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| 7901329 | Becquet D, Hery M, Deprez P, Faudon M, Fache MP, Giraud P, Hery F: / interactions on the control of release in raphe primary cultures. J Neurochem. 1993 Nov;61(5):1692-7. AP-5 blocked the increased [3H] release observed without Mg2+, suggesting that this effect was due to the stimulation of NMDA receptors by endogenous Strychnine (50 microM) blocked the inhibitory effect of indicating an action through strychnine-sensitive inhibitory glycine receptors. |
1(0,0,0,1) | Details |
| 12395122 | Ma JY, Zhao ZQ: The involvement of glia in long-term plasticity in the spinal dorsal horn of the rat. Neuroreport. 2002 Oct 7;13(14):1781-4. The effects of fluorocitrate were abolished by or 2-amino-5-phosphonovaleric acid (AP-5), but not by 6,7-dinitroquinoxaline-2,3-dione (DNQX), picrotoxin or strychnine. These data suggest that spinal glial cells may modulate the central sensitization of nociceptive neurons via NMDA receptors. |
1(0,0,0,1) | Details |
| 9439847 | Wu J, Jin GZ: Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus. Brain Res. 1997 Nov 14;775(1-2):214-8. In the patch-clamp perforated whole-cell recording mode, tetrahydroberberine (THB), a novel (DA) receptor antagonist, inhibits not only DA-induced outward K+ currents, but also -, - or strychnine-induced outward current. |
0(0,0,0,0) | Details |
| 7529821 | Amato A, Ballerini L, Attwell D: Intracellular pH changes produced by uptake in rat hippocampal slices. J Neurophysiol. 1994 Oct;72(4):1686-96. The -evoked acidification was not significantly reduced by blockers of -gated ion channels [6-cyano-7-nitroquinoxaline-2,3- dione (CNQX) and D-aminophosphonovalerate (APV)] nor by blockers of - and -gated channels (picrotoxin and strychnine), and so was not produced by H+ entry through alpha-amino-3--5-methyl-4- isoxazolepropionic acid (AMPA) or (NMDA) receptor channels nor by HCO3- exit through the channels controlled by or 4. |
0(0,0,0,0) | Details |
| 17522628 | Zhang LH, Gong N, Fei D, Xu L, Xu TL: uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology. 2008 Feb;33(3):701-11. Epub 2007 May 23. Moreover, endogenously elevating the concentration with the GlyT1 antagonists facilitated NMDA receptor-dependent long-term potentiation induction, and elicited a strychnine-sensitive current. |
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| 8681892 | Wlaz P, Rolinski Z, Czuczwar SJ: Influence of D-cycloserine on the anticonvulsant activity of phenytoin and carbamazepine against electroconvulsions in mice. Epilepsia. 1996 Jul;37(7):610-7. PURPOSE: D-Cycloserine (DCS) is a high-efficacy partial agonist at the strychnine-insensitive modulatory site within the (NMDA)-receptor/ionophore complex. |
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| 18191027 | Salinska E, Sobczuk A, Lazarewicz JW: Dantrolene antagonizes the glycineB site of the NMDA receptor. . Neurosci Lett. 2008 Feb 20;432(2):137-40. Epub 2008 Jan 10. A binding assay using [(3) H] confirmed this supposition: dantrolene inhibited strychnine-insensitive binding in a dose-dependent way. |
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| 8907326 | Hori Y, Kanda K: Developmental alterations in NMDA receptor-mediated currents in neonatal rat spinal motoneurons. Neurosci Lett. 1996 Feb 23;205(2):99-102. |
5(0,0,0,5) | Details |
| 20092573 | Reed BT, Sullivan SJ, Tsai G, Coyle JT, Esguerra M, Miller RF: The transporter GlyT1 controls receptor coagonist occupancy in the mouse retina. Eur J Neurosci. 2009 Dec;30(12):2308-17. Epub 2009 Dec 10. We examined the role of GlyT1, the high-affinity transporter, in the mouse retina with an emphasis on the role of as a coagonist of (NMDA) receptors. The interpretation of these studies was simplified by blocking post-synaptic inhibition with picrotoxinin and strychnine. |
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| 8558453 | Standaert DG, Testa CM, Rudolf GD, Hollingsworth ZR: Inhibition of glutamate receptor subunit expression by antisense oligonucleotides reveals their role in striatal motor regulation. J Pharmacol Exp Ther. 1996 Jan;276(1):342-52. After NMDAR1 antisense ODN injection, striatal binding of 3H- to sites was not altered, although strychnine-insensitive 3H- binding sites exhibited a small but significant reduction. Recent studies have revealed that NMDA receptors are heteromeric assemblies of structurally related subunits from two families: NMDAR1, which is required for channel activity, and NMDAR2A-D, which modulate the properties of the channels. |
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| 7730987 | Yoshimura M, Nishi S: Primary afferent-evoked - and -mediated IPSPs in substantia gelatinosa neurones in the rat spinal cord in vitro. J Physiol. 1995 Jan 1;482 ( Pt 1):29-38. The short IPSP was reversibly blocked by the glycine receptor antagonist strychnine (0.5-2 microM), while the long IPSP was reversibly blocked by the GABAA receptor antagonist bicuculline (10-20 microM). 3. In the majority of SG neurones, the short and long IPSPs appeared to be disynaptic and were blocked by the non- (non-NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 5-10 microM). |
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| 15490133 | Barth A, Nguyen LB, Barth L, Newell DW: -induced neurotoxicity in organotypic hippocampal slice cultures. Exp Brain Res. 2005 Mar;161(3):351-7. Epub 2004 Oct 14. coactivates (NMDA) receptors by binding to a distinct recognition site on the NR1 subunit. Stimulation or inhibition (strychnine) of the inhibitory strychnine-sensitive glycine receptors did not produce any neurotoxicity. |
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| 7717569 | McFarlane C, Warner DS, Nader A, Dexter F: Glycine receptor antagonism. Anesthesiology. 1995 Apr;82(4):963-8. BACKGROUND: and binding sites are allosterically coupled at the (NMDA) receptor complex. |
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| 9660894 | Dutschmann M, Herbert H: and GABAA receptors in the rat Kolliker-Fuse area control cardiorespiratory responses evoked by trigeminal ethmoidal nerve stimulation. J Physiol. 1998 Aug 1;510 ( Pt 3):793-804. Unilateral injections (n = 5) of the glycine receptor antagonist strychnine into the KF area did not produce any significant effects on EN5-evoked autonomic responses. 6. Unilateral injections (n = 6) of 50-100 nl of the NMDA receptor antagonist AP5 into the KF area led to a significant blockade of the EN5-evoked respiratory depression and bradycardia. |
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| 8152525 | Parsons CG, Gruner R, Rozental J, Millar J, Lodge D: Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology. 1993 Dec;32(12):1337-50. The antagonistic effects of memantine were not reversed by increasing concentrations of (0.1-100 microM) ruling out the possibility of an interaction of memantine with the strychnine-insensitive modulatory site associated with the NMDA receptor-channel complex. |
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| 18199816 | Suwabe T, Fukami H, Bradley RM: Synaptic responses of neurons controlling the parotid and von Ebner salivary glands in rats to stimulation of the solitary nucleus and tract. J Neurophysiol. 2008 Mar;99(3):1267-73. Epub 2008 Jan 16. Use of glutamate receptor antagonists indicated that both AMPA and (NMDA) receptors are involved in the evoked excitatory postsynaptic potentials (EPSPs). Addition of the antagonist strychnine did not affect the amplitude of the IPSPs significantly. |
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| 8114520 | Saransaari P, Oja SS: Strychnine-insensitive binding to cerebral cortical membranes in developing and ageing mice. Mech Ageing Dev. 1993 Nov;72(1):57-66. The alterations in the maximal binding capacities during development and ageing could be of importance in the regulation of NMDA receptors, which have been implicated in synaptic potentiation, developmental processes and various pathological conditions. |
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| 20018830 | Jiang Z, Shen W: Role of neurotransmitter receptors in mediating light-evoked responses in retinal interplexiform cells. J Neurophysiol. 2010 Feb;103(2):924-33. Epub 2009 Dec 16. We find that light-evoked excitatory postsynaptic currents (L-EPSCs) are mediated by AMPA and N-methyl-d-aspartate receptors in IP cells. The light-evoked inhibitory postsynaptic currents (L-IPSCs) in IP cells were primarily mediated by strychnine-sensitive glycine receptors with a small component of (C) receptors. |
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| 7931502 | Inoue T, Chandler SH, Goldberg LJ: Neuropharmacological mechanisms underlying rhythmical discharge in trigeminal interneurons during fictive mastication. J Neurophysiol. 1994 Jun;71(6):2061-73. During application of strychnine (STR), a antagonist, discharge of closer type RA neurons increased in the opener phase of RMA during continuous HCA application. Iontophoretic application of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a specific non- (NMDA) receptor antagonist, suppressed discharge of both closer and opener type RA neurons during RMA. |
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| 11148377 | Vamvakides A: [Effect of or 3-cyclopentyl adamantanamine on the immobility of adult or aged mice, in the forced swim test]. Ann Pharm Fr. 2000 Dec;58(6):420-4. This NMDA receptors dysfunction could render non significant the antagonism of the mice immobility in the FST, induced by AMA or IMI, which could result (in part for IMI) from the anti- effect of these drugs. In contrast AdCP, which may principally act by glycinergic A (strychnine sensitive) effect, inhibiting the release of the brain monoamines and conserved its activity in the FST on aged mice. |
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| 12409996 | Beardsley PM, Ratti E, Balster RL, Willetts J, Trist D: The selective antagonist gavestinel lacks phencyclidine-like behavioral effects. Behav Pharmacol. 2002 Nov;13(7):583-92. Gavestinel [GV150526A; ( E)-3 [(phenylcarbamoil) ethenyl]-4,6-dichloroindole-2-carboxylic acid salt] is a selective antagonist at the strychnine-insensitive site of the -methyl-D- (NMDA) receptor. |
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| 8981605 | Zajaczkowski W, Danysz W: Effects of D-cycloserine and aniracetam on spatial learning in rats with entorhinal cortex lesions. Pharmacol Biochem Behav. 1997 Jan;56(1):21-9. Such a possibility offered by partial agonists of the strychnine-insensitive site of the NMDA receptor (Gly-B site) or positive modulators of AMPA receptors, such as aniracetam. |
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| 8891243 | Razdan B, Kubin J, Mishra OP, Delivoria-Papadopoulos M: Modification of the (co-activator) binding site of the N-methyl-D-aspartate receptor in the guinea pig fetus brain during development following hypoxia. Brain Res. 1996 Sep 9;733(1):15-20. Synaptosomal membranes were prepared and strychnine-insensitive specific [3H] binding was determined During development, the number of binding sites increased (Bmax:392 +/- 30 vs. 583 +/- 30 fmol/mg protein at 45 and 60 days respectively, P < 0.05) where as the affinity remained unchanged (Kd: 190 +/- 9 vs. 211 +/- 30 nM at 45 and 60 days respectively). |
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| 10408246 | Le Guen S, Catheline G, Besson JM: Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat. Eur J Pharmacol. 1999 May 28;373(1):1-11. Administration of an antagonist at the strychnine-insensitive site of the NMDA receptor ((+)-HA-966: R (+)-3-Amino-1-hydroxypyrrolidin-2-one) did not affect the development of morphine tolerance. |
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| 7830058 | Widdowson PS, Trainor A, Lock EA: NMDA receptors in rat cerebellum and forebrain: subtle differences in pharmacology and modulation. J Neurochem. 1995 Feb;64(2):651-61. In the cerebellum, however, [3H] bound to a second site with a 10-fold lower affinity and with a pharmacology that resembled that of the /strychnine chloride channel. [3H]- binding was not affected by agonists or antagonists, nor was [3H] binding affected by agonists in either forebrain or cerebellum. |
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| 17408431 | Kono Y, Shigetomi E, Inoue K, Kato F: Facilitation of spontaneous release by anoxia potentiates NMDA receptor current in the hypoglossal motor neurons of the rat. Eur J Neurosci. 2007 Mar;25(6):1748-56. Epub 2007 Apr 4. This increase was abolished by strychnine, but not by picrotoxin, CNQX or MK-801, indicating release facilitation. |
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| 7796124 | Nowak G, Ordway GA, Paul IA: Alterations in the (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Res. 1995 Mar 27;675(1-2):157-64. This adaptation consists of a reduction in the potency of to displace [3H] 5,7-dichlorokynurenic acid from strychnine-insensitive glycine receptors and a reduction in high affinity, -displaceable [3H] CGP-39653 binding to glutamate receptors. |
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| 8100622 | Corbett R, Dunn RW: Effects of 5,7 dichlorokynurenic acid on conflict, social interaction and plus maze behaviors. Neuropharmacology. 1993 May;32(5):461-6. Antagonists at the (NMDA) receptor site share a number of properties including anticonvulsant and anxiolytic-like behaviors. In particular, selective antagonism at the strychnine-insensitive modulatory site (5,7 DCKA) may represent a new and novel class of compounds with potential therapeutic efficacy in anxiety without some of the side effects associated with other antagonists. |
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| 7700595 | Martin H, Warner DS, Todd MM: Effects of glycine receptor antagonism on spreading depression in the rat. Neurosci Lett. 1994 Oct 24;180(2):285-9. Spreading depression (SD) in the rat brain is inhibited by (NMDA) receptor antagonists. |
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| 9660092 | Kaminski R, Przywara B, Gasior M, Kleinrok Z, Czuczwar SJ: Effect of 5-fluoroindole-2-carboxylic acid (an antagonist of the NMDA receptor-associated site) on the anticonvulsive activity of conventional antiepileptic drugs. J Neural Transm. 1998;105(2-3):133-46. The results suggest that the blockade of the strychnine-insensitive site may lead to an enhancement of the protective activity of some conventional antiepileptic drugs, which is associated with pronounced side-effects and lethality in some cases. |
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| 7693110 | Becquet D, Hery M, Francois-Bellan AM, Giraud P, Deprez P, Faudon M, Fache MP, Hery F: and modulate synthesis and release in rostral and caudal rhombencephalic raphe cells in primary cultures. Neurochem Int. 1993 Sep;23(3):269-83. (10 (-4) M) enhanced metabolism and the induced-effect was antagonized by the selective N-methyl-D-aspartate receptor antagonist D,L-2 amino-5-phosphonovaleric acid. inhibitory effect was totally blocked by strychnine (5 x 10 (-5) M). |
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| 9479666 | Wu WC, Kuo JS, Wang Y, Chai CY: increases arterial pressure and augments -induced pressor responses in the dorsomedial and ventrolateral medulla of cats. J Auton Nerv Syst. 1997 Dec 11;67(3):145-55. Prior microinjection of the following antagonists blocked the Gly-induced pressor responses: 2-amino-5-phosphonopentanoate (AP-5, 25 mM, 30 nl), a specific NMDA receptor antagonist; or diethyl ester (GDEE, 0.5 M, 30 nl), a quisqualate receptor antagonist; or (KYN, 10 mM, 30 nl), a broad spectrum competitive antagonist. Prior treatment with strychnine (3 mM, 30 nl), a specific Gly antagonist, also blocked the Gly-induced pressor responses. |
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| 8846064 | Peterson SL: Infusion of antagonists into the nucleus reticularis pontis oralis inhibits the maximal electroshock seizure response. Brain Res. 1995 Dec 8;702(1-2):101-9. The purpose of the present study was to characterize specific components of the NMDA receptor/ionophore complex that regulate the anticonvulsant activity mediated by the RPO. Bilateral RPO microinfusion of the strychnine-insensitive site partial agonist D-cycloserine and the antagonist 5,7-dichlorokynurenic acid inhibited THE. |
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| 15615833 | MacLeod KM, Carr CE: Synaptic physiology in the cochlear nucleus angularis of the chick. J Neurophysiol. 2005 May;93(5):2520-9. Epub 2004 Dec 22. These excitatory EPSCs were mediated by AMPA and (NMDA) receptors. |
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| 9425176 | Ferragamo MJ, Golding NL, Oertel D: Synaptic inputs to stellate cells in the ventral cochlear nucleus. . J Neurophysiol. 1998 Jan;79(1):51-63. Late EPSPs and late IPSPs were blocked by APV and enhanced by the removal of Mg2+, indicating that the interneurons were driven at least in part through NMDA receptors. |
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| 17537680 | Li DP, Yang Q: Membrane and synaptic properties of nucleus tractus solitarius neurons projecting to the caudal ventrolateral medulla. Auton Neurosci. 2007 Oct 30;136(1-2):69-81. Epub 2007 May 29. Bath application of an ionotropic glutamate receptor antagonist and a non-NMDA receptor antagonist CNQX significantly decreased the firing activity in the majority of labeled NTS neurons. While the glycine receptor antagonist strychnine had no effect on the firing activity, blockade of (A) receptors with bicuculline significantly increased the firing rate in the majority of labeled NTS neurons. |
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| 7674119 | Lambert DM, Geurts M, Scriba GK, Poupaert JH, Dumont P: [Simple derivatives of amino acid neurotransmitters. J Pharm Belg. 1995 Mar-Jun;50(2-3):194-203. They act mainly in the spinal cord and in the brain stem via the strychnine sensitive glycine receptor. exhibits also a key rule in the excitatory neurotransmission in the N-methyl-D-aspartate receptor complex. |
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| 9772232 | Burger RM, Pollak GD: Analysis of the role of inhibition in shaping responses to sinusoidally amplitude-modulated signals in the inferior colliculus. J Neurophysiol. 1998 Oct;80(4):1686-701. We recorded responses from ICc neurons evoked by SAM signals before and during the iontophoretic application of several pharmacological agents: bicuculline, a competitive antagonist for -A (GABAA) receptors; strychnine, a competitive antagonist for glycine receptors; the GABAB receptor blocker, phaclofen, and the (NMDA) receptor blocker, (-)-2-amino-5-phosphonopentanoic acid (AP5). |
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| 9400002 | Parsons CG, Danysz W, Quack G, Hartmann S, Lorenz B, Wollenburg C, Baran L, Przegalinski E, Kostowski W, Krzascik P, Chizh B, Headley PM: Novel systemically active antagonists of the site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. J Pharmacol Exp Ther. 1997 Dec;283(3):1264-75. A series of novel tricyclic pyrido-phthalazine-dione derivatives was tested for antagonistic effects at the strychnine-insensitive modulatory site of the (NMDA) receptor (glycineB). |
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| 18562558 | Kilb W, Hanganu IL, Okabe A, Sava BA, Shimizu-Okabe C, Fukuda A, Luhmann HJ: Glycine receptors mediate excitation of subplate neurons in neonatal rat cerebral cortex. J Neurophysiol. 2008 Aug;100(2):698-707. Epub 2008 Jun 18. -induced responses were blocked by the glycinergic antagonist strychnine, but were unaffected by either the GABAergic antagonist gabazine, the N-methyl-d-aspartate-receptor antagonist d-2-amino-5-phosphonopentanoic acid, or picrotoxin and cyanotriphenylborate, antagonists of alpha-homomeric and alpha1-subunit-containing glycine receptors, respectively. |
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| 8982666 | Srinivasan J, Richens A, Davies JA: Effects of felbamate on veratridine- and K (+)-stimulated release of from mouse cortex. Eur J Pharmacol. 1996 Nov 21;315(3):285-8. Felbamate is a novel anticonvulsant which may modulate the strychnine-insensitive site of the (NMDA) receptor complex. |
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| 8786846 | Jones MG, Szatkowski MS: The role of in anoxia/aglycaemia-induced potentiation of N-methyl-D-aspartate receptor-mediated postsynaptic potentials in the rat hippocampus. Neurosci Lett. 1995 Dec 15;201(3):227-30. The effects of added were strychnine-insensitive and blocked by a competitive antagonist. |
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| 9498733 | Meyer RC, Knox J, Purwin DA, Spangler EL, Ingram DK: Combined stimulation of the and polyamine sites of the NMDA receptor attenuates blockade-induced learning deficits of rats in a 14-unit T-maze. Psychopharmacology. 1998 Feb;135(3):290-5. The objectives were two-fold: (1) to investigate the effects of independent stimulation of the strychnine-insensitive site or the polyamine site; (2) to investigate the effects of simultaneous activation of these two sites. |
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| 17502428 | Smothers CT, Woodward JJ: Pharmacological characterization of -activated currents in HEK 293 cells expressing NR1 and NR3 subunits. J Pharmacol Exp Ther. 2007 Aug;322(2):739-48. Epub 2007 May 14. (NMDA) receptors are important targets for drugs of abuse such as toluene, and ketamine. |
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| 8032669 | Loscher W, Wlaz P, Rundfeldt C, Baran H, Honack D: Anticonvulsant effects of the /NMDA receptor ligands D-cycloserine and but not R-(+)-HA-966 in amygdala-kindled rats. Br J Pharmacol. 1994 May;112(1):97-106. Pharmacological intervention at the strychnine-insensitive glycine receptor by high-efficacy partial agonists with systemic bioavailability may be an effective means of increasing seizure-threshold without concomitantly inducing PCP-like adverse effects. The effects of the /NMDA receptor partial agonists, D-cycloserine and (+)-HA-966 and the full agonist, on focal seizure threshold and behaviour have been determined in amygdala-kindled rats, i.e. a model of focal (partial) epilepsy. |
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| 9704598 | Jenei Z, Janaky R, Varga V, Saransaari P, Oja SS: Interference of S-alkyl derivatives of with brain ionotropic glutamate receptors. Neurochem Res. 1998 Aug;23(8):1085-91. The effects of sulfonate and S-alkyl derivatives of on the binding of and selective ligands of ionotropic and non-NMDA receptors were studied with mouse synaptic membranes. The strychnine-insensitive binding of the coagonist [3H] was attenuated only by and sulfonate. |
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| 16467532 | Torsney C, MacDermott AB: Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. J Neurosci. 2006 Feb 8;26(6):1833-43. This novel A fiber input was polysynaptic in nature and required NMDA receptor activity to be functional. Blockade of local GABAergic and glycinergic inhibition with bicuculline (10 microm) and strychnine (300 nm), respectively, revealed significant A fiber input to lamina I NK1R+ neurons that was predominantly Abeta fiber mediated. |
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| 8566152 | Nankai M, Fage D, Carter C: Striatal NMDA receptor subtypes: the pharmacology of -evoked and release. Eur J Pharmacol. 1995 Nov 3;286(1):61-70. We have examined the inhibitory potencies of MK 801, memantine, dextromethorphan, Mg2+ and of strychnine-insensitive site antagonists on the -evoked (300 microM) release of [14C] and [3H] or [14C] [14C] and [3H] from rat striatal slices. |
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| 19394327 | Muth-Selbach U, Hermanns H, Stegmann JU, Kollosche K, Freynhagen R, Bauer I, Lipfert P: Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system. Eur J Pharmacol. 2009 Jun 24;613(1-3):68-73. Epub 2009 Apr 24. The effect of intrathecally administered (an agonist at the -binding site at the NMDA-receptor), its inactive isomer CGP 78608 (antagonist at the glycineB-site of the NMDA-receptor) and strychnine (antagonist at inhibitory glycine-receptors) on lidocaine-induced antinociception was examined. The effect of intrathecally administered (an agonist at the -binding site at the NMDA-receptor), its inactive isomer CGP 78608 (antagonist at the glycineB-site of the NMDA-receptor) and strychnine (antagonist at inhibitory glycine-receptors) on lidocaine-induced antinociception was examined. |
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| 11118498 | Smith AJ, Owens S, Forsythe ID: Characterisation of inhibitory and excitatory postsynaptic currents of the rat medial superior olive. J Physiol. 2000 Dec 15;529 Pt 3:681-98. We characterised the excitatory and inhibitory synaptic currents of MSO neurones in 3- to 14-day-old rats using whole-cell patch-clamp methods in a brain slice preparation.A dual component EPSC was mediated by AMPA and NMDA receptors. Following blockade of glutamate receptors, a monosynaptic strychnine-sensitive response was evoked on stimulation of the MNTB, indicative of a glycine receptor-mediated IPSC. |
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| 8574651 | Viana Di Prisco G, Ohta Y, Bongianni F, Grillner S, Dubuc R: Trigeminal inputs to reticulospinal neurones in lampreys are mediated by excitatory and inhibitory amino acids. Brain Res. 1995 Oct 9;695(1):76-80. This effect was antagonized by 2-amino-5-phosphonopentanoate (2-AP5) or reversed by restoring Mg2+ ions to the perfusate suggesting the activation of (NMDA) receptors. |
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| 8821739 | Kanthasamy AG, Matsumoto RR, Gunasekar PG, Trunong DD: Excitoprotective effect of felbamate in cultured cortical neurons. . Brain Res. 1995 Dec 24;705(1-2):97-104. Exogenous addition of failed to modulate the effect of felbamate on -induced neurotoxicity or Ca2+ influx, although corresponding changes induced by the strychnine-insensitive antagonist, 5,7-dichlorokynurenic acid could be modulated with Taken together, these results suggest that felbamate acts through a site on the NMDA receptor that is distinct from the strychinine-insensitive site, and that the effect of the drug on neuronal Ca2+ may be pivotal to its neuroprotective mechanism. |
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| 10670445 | Ishikawa T, Marsala M, Sakabe T, Yaksh TL: Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal or (A) receptor antagonist. Neuroscience. 2000;95(3):781-6. Intrathecal strychnine antagonist) or bicuculline (A) antagonist) yields a touch-evoked agitation that is blocked by N-methyl-D-aspartate receptor antagonism. Intrathecal strychnine antagonist) or bicuculline (A) antagonist) yields a touch-evoked agitation that is blocked by N-methyl-D-aspartate receptor antagonism. |
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| 10332095 | Ballerini L, Galante M, Grandolfo M, Nistri A: Generation of rhythmic patterns of activity by ventral interneurones in rat organotypic spinal slice culture. J Physiol. 1999 Jun 1;517 ( Pt 2):459-75. Bursting was fully suppressed by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and reduced in amplitude and duration by (NMDA) receptor antagonism without change in periodicity. The much slower rhythmic pattern induced by strychnine and bicuculline was also accelerated by high-K+ solution. 5. |
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| 10938255 | Krolo M, Stuth EA, Tonkovic-Capin M, Hopp FA, McCrimmon DR, Zuperku EJ: Relative magnitude of tonic and phasic synaptic excitation of medullary inspiratory neurons in dogs. Am J Physiol Regul Integr Comp Physiol. 2000 Aug;279(2):R639-49. The findings suggest that two-thirds of the excitatory drive to caudal VRG I neurons is tonic and mediated by NMDA receptors and the other third is ramp-like phasic and mediated by non-NMDA receptors. |
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| 10974307 | Chen J, Heinke B, Sandkuhler J: Activation of group I metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn. Neuropharmacology. 2000 Sep;39(12):2231-43. In the presence of bicuculline and strychnine, bath application of (1S,3R)-1-aminocyclopentane-1, 3-dicarboxylic acid ((1S,3R)-ACPD) or the specific group I mGluR agonist (S)-3,5-dihydroxyphenylglycine ((S)-3,5- but not the specific group II mGluR agonist (2S,2'R,3'R)-2-(2', 3'-dicarboxycyclopropyl) (DCG-IV) for 20 min produced an acute and a long-term depression of synaptic strength. |
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| 10515985 | Ikeda H, Asai T, Randic M, Murase K: Robust suppression of afferent-induced excitation in the rat spinal dorsal horn after conditioning low-frequency stimulation. J Neurophysiol. 1999 Oct;82(4):1957-64. However, treatments with the (A) receptor antagonist bicuculline (1 microM) and the glycine receptor antagonist strychnine (0.3 microM) did not affect suppression induction and maintenance. |
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| 8923484 | Simpson RK Jr, Gondo M, Robertson CS, Goodman JC: Reduction in the mechanonociceptive response by intrathecal administration of and related compounds. Neurochem Res. 1996 Oct;21(10):1221-6. Neuropathic rats created by unilateral partial ligation of the sciatic nerve were treated with intrathecal infusion of strychnine, MK-801, or 5,7-DKA at 0.1 mumol, or artificial CSF for 2 hours at a rate of 10 microliters/min. |
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| 17646495 | Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM: Anesthetic-like modulation of a type A, strychnine-sensitive and N-methyl-d-aspartate receptors by coreleased neurotransmitters. Anesth Analg. 2007 Aug;105(2):386-92. |
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| 9715806 | Caba M, Komisaruk BR, Beyer C: Analgesic synergism between AP5 (an NMDA receptor antagonist) and vaginocervical stimulation in the rat. Pharmacol Biochem Behav. 1998 Sep;61(1):45-8. We propose that AP5 potentiates the analgesic effect of VS by two mechanisms: (a) antagonizing the putative pain-producing action of and acting jointly at the NMDA receptor, and consequently, (b) permitting the unimpeded expression of the analgesic action of inhibitory neurotransmitters released by VS (e.g., at the strychnine-sensitive receptor, and |
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| 8476382 | Fishkin RJ, Ince ES, Carlezon WA Jr, Dunn RW: D-cycloserine attenuates -induced learning and memory deficits in rats. Behav Neural Biol. 1993 Mar;59(2):150-7. D-Cycloserine (DCS), a partial agonist at the strychnine-insensitive site on the (NMDA) receptor complex, was investigated for its effects on -induced dementia in the MWM and T-maze paradigms. |
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| 7713059 | White HS, Harmsworth WL, Sofia RD, Wolf HH: Felbamate modulates the strychnine-insensitive glycine receptor. . Epilepsy Res. 1995 Jan;20(1):41-8. The present investigation examined its ability to modulate the strychnine-insensitive glycine receptor associated with the (NMDA) receptor. |
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| 10215643 | Witkin JM, Gasior M, Heifets B, Tortella FC: Anticonvulsant efficacy of antagonists against convulsions induced by cocaine. J Pharmacol Exp Ther. 1999 May;289(2):703-11. Anticonvulsant efficacy was achieved by blockade of both competitive and noncompetitive modulatory sites on the NMDA receptor complex. Thus, competitive antagonists, ion-channel blockers, polyamine antagonists, and functional blockers of the strychnine-insensitive modulatory site all prevented cocaine seizures. |
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| 17011596 | Zhao X, Marszalec W, Toth PT, Huang J, Yeh JZ, Narahashi T: In vitro galantamine-memantine co-application: mechanism of beneficial action. Neuropharmacology. 2006 Dec;51(7-8):1181-91. Epub 2006 Sep 29. Since Alzheimer's disease is known to be associated with down-regulation of the cholinergic and systems, most of these drugs inhibit acetylcholinesterase, potentiate the activity of nicotinic acetylcholine receptors (nAChRs), or modulate NMDA receptors. |
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| 7953730 | Baran H, Loscher W, Mevissen M: The /NMDA receptor partial agonist D-cycloserine blocks kainate-induced seizures in rats. Brain Res. 1994 Aug 1;652(2):195-200. The data demonstrate that pharmacological manipulation of the strychnine-insensitive site is a powerful means of protecting against kainate-induced seizures. |
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| 16262635 | Ruscheweyh R, Sandkuhler J: Long-range oscillatory Ca2+ waves in rat spinal dorsal horn. Eur J Neurosci. 2005 Oct;22(8):1967-76. The Ca2+ waves were associated with large depolarizing shifts of the membrane potential of participating neurons and were most likely synaptically mediated because they were abolished by blockade of action potentials or (NMDA) receptors. |
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| 14622582 | Gomeza J, Hulsmann S, Ohno K, Eulenburg V, Szoke K, Richter D, Betz H: Inactivation of the transporter 1 gene discloses vital role of glial uptake in glycinergic inhibition. Neuron. 2003 Nov 13;40(4):785-96. The transporter subtype 1 (GlyT1) is widely expressed in astroglial cells throughout the mammalian central nervous system and has been implicated in the regulation of (NMDA) receptor activity. In brainstem slices from GlyT1-deficient mice, in vitro respiratory activity is strikingly reduced but normalized by the glycine receptor (GlyR) antagonist strychnine. |
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| 8833754 | Yu W, Miller RF: The mechanism by which NBQX enhances currents in retinal ganglion cells. Brain Res. 1996 Feb 19;709(2):184-96. Thus, the NBQX-enhanced current is entirely mediated by NMDA receptors. In the presence of strychnine and picrotoxin, the NBQX-induced enhancement of currents is eliminated, suggesting that NBQX facilitates the expression of currents by a selective and partial reduction of inhibitory mechanisms. |
1(0,0,0,1) | Details |
| 9215988 | Auer RN: Structural neurotoxicologic investigation of the antagonist 5-nitro-6,7-dichloroquinoxalinedione (ACEA-1021). Neurotoxicology. 1997;18(1):53-62. Since previous studies have shown anti-ischemic efficacy of this compound in focal, but not global ischemia, it appears that the therapeutic profile of this antagonist of the strychnine-insensitive site is similar, but the toxicologic structural profile is different, from NMDA receptor antagonists. This investigation used 38 Wistar rats to determine whether the structural toxicologic profile of a newly developed halogenated quinoxalinedione derivative, a pharmacologic antagonist of the site on the NMDA receptor complex, is identical to that seen with MK-801. |
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| 18472218 | Kim DK, Kwak J, Kim SJ, Kim J: Long-lasting enhancement in the intrinsic excitability of deep dorsal horn neurons. Pain. 2008 Sep 30;139(1):181-9. Epub 2008 May 9. Under bath application of bicuculline (10 microM) and strychnine (1 microM), PS induced E-S potentiation and long-lasting increases in IE. This intrinsic plasticity requires a rise in postsynaptic Ca (2+) and NMDA receptor activation during the induction period, and this process might be mediated by the down-regulation of small-conductance -dependent (SK) channels. |
1(0,0,0,1) | Details |
| 11127572 | Zhang S, Kashii S, Yasuyoshi H, Kikuchi M, Honda Y, Kaneda K, Sato S, Akaike A: Protective effects of ifenprodil against -induced neurotoxicity in cultured retinal neurons. Graefes Arch Clin Exp Ophthalmol. 2000 Oct;238(10):846-52. The protective effects of ifenprodil against neurotoxicity were significantly reduced by a polyamine modulatory site agonist, but not by a strychnine-insensitive site agonist. CONCLUSION: The findings suggest that ifenprodil protected the cultured retinal cells we used in this study against neurotoxicity by its inhibitory action on the polyamine modulatory site of the NMDA receptor. |
1(0,0,0,1) | Details |
| 11129111 | Harkin A, Nally R, Kelly JP, Leonard BE: Effects of reboxetine and treatments alone and in combination on the binding properties of cortical and beta1-adrenergic receptors in an animal model of depression. J Neural Transm. 2000;107(10):1213-27. In the present investigation we examined the effects of the reuptake inhibitor, reboxetine, the reuptake inhibitor, alone and in combination on the binding properties of cortical NMDA receptors and cortical beta1-adrenoceptors following 14 days of treatment in the olfactory bulbectomized rat model of depression. A decrease in the potency of to displace the strychnine insensitive antagonist [3H] 5,7 dichlorokynurenic acid (5,7 DCKA) was observed in cortical homogenates of OB rats when compared to sham-operated controls. |
1(0,0,0,1) | Details |
| 8097266 | Lopez-Colome AM, Salceda R, Fragoso G: Specific interaction of with membranes from cultured retinal pigment epithelium. J Neurosci Res. 1993 Mar 1;34(4):454-61. Excitatory amino acid analogues acting at the NMDA-receptor also displaced bound and a noticeable stimulation of specific binding of this ligand by was shown; this effect was mimicked by and 1--3-aminopyrrolidone-2 (HA-966) but not by 7-chlorokynurenate, and was not inhibited by strychnine. |
0(0,0,0,0) | Details |
| 8587649 | Perez-Leon JA, Salceda R: Different specific binding sites of [3H] and [3H] strychnine in synaptosomal membranes isolated from frog retina. Neurochem Res. 1995 Aug;20(8):915-22. |
0(0,0,0,0) | Details |
| 9671104 | Garcia MC, Celuch SM, Adler-Graschinsky E: Involvement of and glutamate receptors in the blood pressure responses to intrathecally injected sodium nitroprusside in anesthetized rats. Eur J Pharmacol. 1998 May 22;349(2-3):245-52. The blood pressure responses to sodium nitroprusside were not modified by blockade of muscarinic receptors with methyl atropine (164 nmol, i.t.), or of nicotinic receptors with hexamethonium (211 nmol, i.t.), of alpha1-adrenoceptors with prazosin (3.1 nmol, i.t.), of alpha2-adrenoceptors with yohimbine (2.8 micromol/kg, i.v.), of receptors with methysergide (5.1 micromol/kg, i.v.), or of glycine receptors with strychnine (65 nmol, i.t.). |
0(0,0,0,0) | Details |
| 12522187 | Miura A, Kawatani M, De Groat WC: Excitatory synaptic currents in lumbosacral parasympathetic preganglionic neurons evoked by stimulation of the dorsal commissure. J Neurophysiol. 2003 Jan;89(1):382-9. Excitatory postsynaptic currents (EPSCs) were evoked in PGN by stimulation of DCM in the presence of bicuculline methiodide (10 microM) and strychnine (1 microM) to block inhibitory pathways. |
0(0,0,0,0) | Details |
| 15888962 | Leewanich P, Tohda M, Takayama H, Sophasan S, Watanabe H, Matsumoto K: Corymine potentiates -induced currents in Xenopus oocytes expressing NR1a/NR2B glutamate receptors. J Pharmacol Sci. 2005 May;98(1):58-65. Epub 2005 May 12. However, it is unclear whether this alkaloid can modulate the function of the (NMDA) receptor on which acts as a co-agonist via strychnine-insensitive binding sites. |
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| 15288514 | Peterson SL, Purvis RS, Griffith JW: Differential neuroprotective effects of the NMDA receptor-associated site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus. Neurotoxicology. 2004 Sep;25(5):835-47. The present study determined whether 1-aminocyclopropanecarboxylic acid (ACPC) or D-cycloserine (DCS), both partial agonists of the strychnine-insensitive site on the NMDA receptor ionophore complex, exerted anticonvulsant or neuroprotectant activity in Li-pilo SE. |
33(0,1,1,3) | Details |
| 9224858 | Hu RQ, Davies JA: Glutamate receptor antagonists reduce spontaneous epileptiform activity in cortical wedges prepared from DBA/2 mice. Exp Brain Res. 1997 Jun;115(2):311-8. The (NMDA) receptor antagonist 3-(2-carboxypiperazin-4-yl)-propenyl-1-phosphonic acid (CPP) and the non-competitive NMDA receptor channel blocker ketamine produced a significant reduction of these spontaneous depolarizations. 7-Chlorokynurenic acid (7-CKA), an antagonist at the strychnine-insensitive site on the NMDA receptor, also exerted an inhibitory effect. |
31(0,1,1,1) | Details |
| 9121816 | Sorkin LS, Puig S: Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist. Pain. 1996 Dec;68(2-3):283-92. Subsequent co-administration of an NMDA receptor antagonist (AP-7, 2.0 mM) preferentially blocked strychnine-associated effects without changing the original receptive field characteristics. |
31(0,1,1,1) | Details |
| 9352316 | Maruoka Y, Ohno Y, Tanaka H, Yasuda H, Ohtani K, Sakamoto H, Kawabe A, Tamamura C, Nakamura M: Selective depression of the spinal polysynaptic reflex by the NMDA receptor antagonists in an isolated spinal cord in vitro. Gen Pharmacol. 1997 Oct;29(4):645-9. Inhibition of the PSR by 7-Clkyn persisted in the presence of strychnine, which markedly increased the PSR activity by itself. 5. |
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| 9335079 | Geter-Douglass B, Witkin JM: Dizocilpine-like discriminative stimulus effects of competitive NMDA receptor antagonists in mice. Psychopharmacology. 1997 Sep;133(1):43-50. Compounds acting at other sites on the NMDA receptor complex, including the partial agonist at the strychnine-insensitive site, ACPC, and the polyamine antagonist, ifenprodil, failed to substitute fully. |
4(0,0,0,4) | Details |
| 17241274 | Fossat P, Sibon I, Le Masson G, Landry M, Nagy F: L-type channels and NMDA receptors: a determinant duo for short-term nociceptive plasticity. Eur J Neurosci. 2007 Jan;25(1):127-35. |
4(0,0,0,4) | Details |
| 10848542 | Cohen ED: Light-evoked excitatory synaptic currents of X-type retinal ganglion cells. J Neurophysiol. 2000 Jun;83(6):3217-29. Using isolated and sliced preparations of cat and ferret retina, the light-evoked EPSCs of X cells were isolated by adding picrotoxin and strychnine to the bath to remove synaptic inhibition. (NMDA) receptors contribute significantly to the light-evoked EPSCs of ON- and OFF-X cells at many different holding potentials. |
4(0,0,0,4) | Details |
| 9112643 | Nowak G: antagonists in the olfactory bulbectomy animal model of depression: effect on the cortical NMDA receptor complex. Pol J Pharmacol. 1996 Mar-Apr;48(2):137-43. We report that chronic administration of (20 mg/kg) and (10 mg/kg) did not reduced OB-induced hyperactivity, although these drugs reduced the potency of to inhibit [3H] 5,7-dichlorokynurenic acid (DCKA) binding to strychnine-insensitive sites of the NMDA receptor complex. |
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| 12117508 | Wu SH, Ma CL, Sivaramakrishnan S, Oliver DL: Synaptic modification in neurons of the central nucleus of the inferior colliculus. Hear Res. 2002 Jun;168(1-2):43-54. Excitatory postsynaptic currents (EPSCs) were elicited by stimulation of synaptic inputs under the condition that the synaptic inhibition was suppressed by strychnine and picrotoxin. The potentiated EPSCs consisted of alpha-amino-3--5-methyl-4-isoxazolepropionic acid (AMPA) receptor and NMDA receptor mediated components. |
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| 10228452 | Micheli F, Di Fabio R, Capelli AM, Cugola A, Curcuruto O, Feriani A, Gastaldi P, Gaviraghi G, Marchioro C, Orlandi A, Pozzan A, Quaglia AM, Reggiani A, van Amsterdam F: Cycloalkyl -2-carboxylates as useful tools for mapping the "north-eastern" region of the binding site associated with the NMDA receptor. Arch Pharm. 1999 Mar;332(3):73-80. Among the derivatives prepared, 3-[2-(1-adamantylaminocarbonyl) ethenyl]-4,6-dichloroindole-2 -carboxylic acid 6b and 3-[2-(norbornylaminocarbonyl) ethenyl]-4,6-dichloroindole-2-c arboxylic acid 6l were found to be antagonists acting at the strychnine-insensitive binding site, showing nanomolar affinity for the binding site (Ki = 63 and 19 nM, respectively), coupled with high glutamate receptor selectivity (IC50 > 10 (-5) M at the AMPA, KA binding sites) and high in vivo potency after systemic administration by inhibition of convulsion induced by in mice. |
2(0,0,0,2) | Details |
| 12960774 | Meier J, Schmieden V: Inhibition of alpha-subunit glycine receptors by quinoxalines. Neuroreport. 2003 Aug 6;14(11):1507-10. Quinoxalines are widely used compounds in electrophysiological studies to separate excitatory and inhibitory neurotransmission mediated by the strychnine-insensitive and strychnine-sensitive glycine receptor GlyR), respectively. Our data indicates that these quinoxalines applied at concentrations sufficient to block NMDA receptor also attenuate GlyR responses. |
1(0,0,0,1) | Details |
| 9766836 | Sorkin LS, Puig S, Jones DL: Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists. Pain. 1998 Aug;77(2):181-90. Subsequent co-administration of an NMDA receptor antagonist (AP-7, 2.0 mM) was without any apparent effect on either basal or bicuculline-enhanced responses. The inability of AP-7 to reverse the bicuculline-associated hyperreactivity also contrasts with the AP-7 reversal of the strychnine-associated hyperreactivity. |
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| 12661758 | Noh JH, Choi S, Lee JH, Betz H, Kim JI, Park CS, Lee SM, Nah SY: Effects of ginsenosides on glycine receptor alpha1 channels expressed in Xenopus oocytes. Mol Cells. 2003 Feb 28;15(1):34-9. Recent reports showed that ginsenosides attenuate nicotinic acetylcholine and NMDA receptor channel activity. Glycine receptor antagonist strychnine completely blocked the inward current elicited by plus ginsenoside Rf. |
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| 8761926 | el Manira A, Shupliakov O, Fagerstedt P, Grillner S: Monosynaptic input from cutaneous sensory afferents to fin motoneurons in lamprey. J Comp Neurol. 1996 Jun 10;369(4):533-42. The amplitude of the monosynaptic excitatory postsynaptic potential (EPSP) s was reduced by administration of the (NMDA) receptor antagonist DL,2 amino-5-phosphovaleric acid (APV). Sensory stimulation could also elicit di- or oligosynaptic inhibitory postsynaptic potential (IPSP) s, which were blocked by the antagonist strychnine, resulting in the appearance of large monosynaptic EPSPs, which could induce action potentials. |
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| 17462677 | Igartua I, Solis JM, Bustamante J: -induced long-term synaptic potentiation is mediated by the transporter GLYT1. Neuropharmacology. 2007 Jun;52(8):1586-95. Epub 2007 Mar 14. These results indicate that LTP-GLY requires the activation of GLYT1, a transporter co-localized and associated to NMDA receptors. This LTP-GLY is independent of both strychnine-sensitive glycine receptors and nifedipine-sensitive channels. |
1(0,0,0,1) | Details |
| 7684071 | Calligaro DO, O'Malley PJ, Monn JA: beta-Amyloid (25-35) or substance P stimulates [3H] MK-801 binding to rat cortical membranes in the presence of and J Neurochem. 1993 Jun;60(6):2297-303. The compounds do not appear to act through the strychnine-insensitive binding site because neither beta-amyloid (25-35) nor substance P displaced [3H] binding. |
0(0,0,0,0) | Details |
| 7881731 | Clarke PB, Reuben M: Inhibition by dizocilpine (MK-801) of striatal release induced by MPTP and MPP+: possible action at the dopamine transporter. Br J Pharmacol. 1995 Jan;114(2):315-22. In this assay, (even in the absence of Mg2+ and with added and strychnine) did not evoked [3H]- release. 4. |
0(0,0,0,0) | Details |
| 10958157 | Pozza MF, Zimmerman K, Bischoff S, Lingenhohl K: Electrophysiological characterization of CGP68730A a N-methyl-D- antagonist acting at the strychnine-insensitive site. Prog Neuropsychopharmacol Biol Psychiatry. 2000 May;24(4):647-70. Thus, CGP68730A seems to be a selective antagonist at the strychnine-insensitive coagonist site of the NMDA receptor. |
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| 9259023 | Furuya Y, Ogura H: Competitive and strychnine-insensitive -site antagonists disrupt prepulse inhibition. Pharmacol Biochem Behav. 1997 Aug;57(4):909-13. PPI was also disrupted by bilateral intracerebroventricular administration of 5,7-dichlorokyn urenate (10 and 20 micrograms/side X 2), an antagonist at the strychnine-insensitive glycine receptor, which is an allosteric binding site in the NMDA receptor-channel complex. |
33(0,1,1,3) | Details |
| 12909195 | Petty MA, Neumann-Haefelin C, Kalisch J, Sarhan S, Wettstein JG, Juretschke HP: In vivo neuroprotective effects of ACEA 1021 confirmed by magnetic resonance imaging in ischemic stroke. Eur J Pharmacol. 2003 Aug 1;474(1):53-62. The neuroprotective activity of ACEA 1021 (5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione; licostinel), a selective antagonist at the strychnine-insensitive site associated with the NMDA receptor complex, has been investigated in various models of focal cerebral ischemia. |
31(0,1,1,1) | Details |
| 9895138 | Toru M: Biological research on schizophrenia. . Psychiatry Clin Neurosci. 1998 Dec;52 Suppl:S170-2. Glutamate receptors, such as the kainate receptor labeled by 3H-kainate, the (NMDA) receptor by 3H MK801, and the strychnine-insensitive sites in the NMDA receptor by 3H- increased significantly in various cortical areas of schizophrenic brains. |
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| 8774451 | Kotak VC, Sanes DH: Developmental influence of glycinergic transmission: regulation of NMDA receptor-mediated EPSPs. J Neurosci. 1996 Mar 1;16(5):1836-43. Second, continuous release of a glycine receptor antagonist, strychnine (SN), was used to decrease transmission. |
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| 7855218 | Ginski MJ, Witkin JM: Sensitive and rapid behavioral differentiation of N-methyl-D-aspartate receptor antagonists. Psychopharmacology. 1994 May;114(4):573-82. An antagonist of the strychnine-insensitive glycine receptor (7-chlorokynurenic acid) did not affect performance on either test. |
3(0,0,0,3) | Details |
| 8099620 | Nowak G, Trullas R, Layer RT, Skolnick P, Paul IA: Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with and 1-aminocyclopropanecarboxylic acid. J Pharmacol Exp Ther. 1993 Jun;265(3):1380-6. These effects were compared to a chronic regimen of 1-aminocyclopropanecarboxylic acid, a high-affinity partial agonist at strychnine-insensitive glycine receptors which mimics the effects of in preclinical models predictive of antidepressant action. |
3(0,0,0,3) | Details |
| 7894261 | Plaznik A, Palejko W, Nazar M, Jessa M: Effects of antagonists at the NMDA receptor complex in two models of anxiety. Eur Neuropsychopharmacol. 1994 Dec;4(4):503-12. The effects of an antagonist at the strychnine insensitive site (5,7-dichlorokynurenic acid, i.c.v.), and of noncompetitive (MK-801, i.p.) and competitive (CGP 37849, i.p.; CGP 39551, i.p.; AP-7, i.c.v.) antagonists were compared with diazepam (i.p.) in two animal models of anxiety (the open field exploratory behavior of non-habituated rats, and the Vogel conflict test). |
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| 9125436 | Kaputlu I, Uzbay T: L-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice. Brain Res. 1997 Apr 4;753(1):98-101. (NMDA) receptor stimulation which releases and raises levels, mediates epileptiform activity induced by various agents. |
2(0,0,0,2) | Details |
| 8887974 | Urwyler S, Laurie D, Lowe DA, Meier CL, Muller W: Biphenyl-derivatives of 2-amino-7-phosphonoheptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonist--I. Neuropharmacology. 1996 Jun;35(6):643-54. They have no relevant affinities for the strychnine-insensitive co-agonist site or the MK-801/PCP channel blocking site on the NMDA receptor complex. |
2(0,0,0,2) | Details |
| 10091723 | Nowak G, Ossowska G, Jopek R, Papp M: Strychnine-insensitive / sites are altered in two stress models of depression. Pol J Pharmacol. 1998 Jul-Oct;50(4-5):365-9. The present results demonstrate the involvement of the cortical NMDA receptor complex in the animal models of depression. |
1(0,0,0,1) | Details |
| 18692523 | Lavrov I, Cheng J: Methodological optimization of applying neuroactive agents for the study of locomotor-like activity in the mudpuppies (Necturus maculatus). J Neurosci Methods. 2008 Sep 15;174(1):97-102. Epub 2008 Jul 23. Superfusion with AP-5, a NMDA receptor antagonist, produced dose-dependent inhibition of the ongoing walking-like activity induced by and completely blocked the activity at 20 microM. Superfusion of strychnine, a glycine receptor antagonist, blocked the walking-like activity at concentrations of 3-5 microM, while its bolus application altered -induced, but not -induced, walking-like activity to a synchronized pattern. |
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| 11396606 | Lopez-Corcuera B, Geerlings A, Aragon C: neurotransmitter transporters: an update. Mol Membr Biol. 2001 Jan-Mar;18(1):13-20. This action of is mediated by the strychnine-sensitive glycine receptor, whose activation produces inhibitory post-synaptic potentials. In addition, modulates excitatory neurotransmission by potentiating the action of at (NMDA) receptors. |
1(0,0,0,1) | Details |
| 7956307 | Lopez-Colome AM, Fragoso G, Wright CE, Sturman JA: Excitatory amino acid receptors in membranes from cultured human retinal pigment epithelium. Curr Eye Res. 1994 Aug;13(8):553-60. These data suggest the presence of either an NMDA-receptor sensitive to the metabotropic agonist trans-ACPD or alternatively, the presence of two different populations of receptors with similar affinity for the agonist: and metabotropic. Stimulation by was dose-dependent, insensitive to strychnine and 80% inhibited by 7-chlorokynurenate. |
1(0,0,0,1) | Details |
| 8549613 | Kehne JH, Baron BM, Harrison BL, McCloskey TC, Palfreyman MG, Poirot M, Salituro FG, Siegel BW, Slone AL, Van Giersbergen PL, et al.: MDL 100,458 and MDL 102,288: two potent and selective glycine receptor antagonists with different functional profiles. Eur J Pharmacol. 1995 Sep 15;284(1-2):109-18. The present study compared the biochemical and behavioral profiles of two strychnine-insensitive glycine receptor antagonists, MDL 100,458 (3-(benzoylmethylamino)-6-chloro-1H--2- carboxylic acid) and MDL 102,288 (5,7-dichloro-1,4-dihydro-4-[[[4- [(methoxycarbonyl) amino] phenyl] sulfonyl] imino]- monohydrate). |
0(0,0,0,0) | Details |
| 16360285 | Otsuguro K, Ohta T, Ito S: modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro. Neuroscience. 2006;138(1):281-91. Epub 2005 Dec 19. Unlike Zn (2+), strychnine (5 microM), a glycine receptor antagonist, and (S),9 (R)-(-)-bicuculline methobromide (10 microM), a (A) receptor antagonist, potentiated both fast polysynaptic reflex potential and slow ventral root potential. |
0(0,0,0,0) | Details |
| 8383742 | McCabe RT, Wasterlain CG, Kucharczyk N, Sofia RD, Vogel JR: Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors. J Pharmacol Exp Ther. 1993 Mar;264(3):1248-52. |
0(0,0,0,0) | Details |
| 10890022 | Nishikawa T, Yamamoto N, Tsuchida H, Umino A, Kawaguchi N: [Endogenous in mammalian brains] . Nihon Shinkei Seishin Yakurigaku Zasshi. 2000 Feb;20(1):33-9. It is well established that, like and D- potentiates neurotransmission via the (NMDA) receptor by selective stimulation of its strychnine-insensitive site and acts as a co-agonist of the glutamate receptor. |
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| 19023642 | Hamasu K, Shigemi K, Tsuneyoshi Y, Yamane H, Sato H, Denbow DM, Furuse M: Intracerebroventricular injection of and D- induces sedative and hypnotic effects by different mechanisms under an acute stressful condition in chicks. Amino Acids. 2010 Jan;38(1):57-64. Epub 2008 Nov 21. To clarify the mechanism by which and D- induce sedative and hypnotic effects, the contribution of the strychnine-sensitive glycine receptor (glycine receptor) and glutamate receptor (NMDA receptor) were further investigated. |
32(0,1,1,2) | Details |
| 8096081 | Forsythe ID, Barnes-Davies M: The binaural auditory pathway: excitatory amino acid receptors mediate dual timecourse excitatory postsynaptic currents in the rat medial nucleus of the trapezoid body. Proc Biol Sci. 1993 Feb 22;251(1331):151-7. Other smaller EPSCS mediated by and non-NMDA receptors, and a strychnine-sensitive synaptic current, are also present. |
32(0,1,1,2) | Details |
| 11281957 | Heresco-Levy U, Javitt DC, Ermilov M, Silipo G, Shimoni J: Double-blind, placebo-controlled, crossover trial of D-cycloserine adjuvant therapy for treatment-resistant schizophrenia. Int J Neuropsychopharmacol. 1998 Dec;1(2):131-135. The tuberculostatic compound D-cycloserine (DCS) acts as a partial agonist at the strychnine-insensitive regulatory site on the NMDA receptor complex. |
31(0,1,1,1) | Details |
| 9629967 | Song XJ, Zhao ZQ: Cooperative interaction among the various regulatory sites within the NMDA receptor-channel complex in modulating the evoked responses to noxious thermal stimuli of spinal dorsal horn neurons in the cat. Exp Brain Res. 1998 May;120(2):257-62. The specific recognition site antagonist, DL-2-amino-5-phosphonovaleratic acid (APV), the strychnine-insensitive site antagonist 7-chlorokynurenic acid (7CKA), the polyamine site antagonist ifenprodil (IFEN), and the phencyclidine (PCP) site antagonists ketamine (KET) and MK-801 (40-100 nA) significantly reduced (t-tests, P < 0.01) the noxious thermal stimulus-evoked responses in about 70% of the neurons by (mean +/- SE) 54.1 +/- 5.8% (n = 19), 80.8 +/- 4.7% (n = 16), 51.1 +/- 6.4% (n = 10), 77 +/- 4.9% (n = 16) and 81.2 +/- 8.1% (n = 5), respectively. |
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| 11882376 | Jiang MC, Alheid GF, Nunzi MG, Houk JC: Cerebellar input to magnocellular neurons in the red nucleus of the mouse: synaptic analysis in horizontal brain slices incorporating cerebello-rubral pathways. Neuroscience. 2002;110(1):105-21. The residual potentials were identified as NMDA receptor components since they (i) were blocked by the addition of the NMDA receptor antagonist, D,L-2-amino-5-phosphonovaleric acid (APV), (ii) were voltage-dependent, and (iii) were enhanced by Mg (2+) removal. Excitatory components of the evoked potentials were studied after blocking inhibitory components with picrotoxin (100 microM) and strychnine (5 microM). |
3(0,0,0,3) | Details |
| 9029269 | Berman FW, Murray TF: Characterization of toxicity in cultured rat cerebellar granule neurons at reduced temperature. J Biochem Toxicol. 1996;11(3):111-9. The non-NMDA receptor antagonist, 6-cyano-7-nitroquinoxalinedione (CNQX), potently protected against challenge, although the contribution of antagonism at strychnine-insensitive sites could not be excluded. To further characterize the non-NMDA receptor contribution to the excitotoxic response, the promiscuity of interaction with ionotropic receptors was simulated by exposing neurons to in the presence of non-NMDA receptor agonists. |
3(0,0,0,3) | Details |
| 18554813 | Cervetto C, Taccola G: GABAA and strychnine-sensitive glycine receptors modulate -evoked release from rat spinal motoneurons: a possible role in neuroprotection. Neuroscience. 2008 Jul 17;154(4):1517-24. Epub 2008 May 3. As a measure of glutamatergic excitation, we have studied the release induced by (NMDA) receptor stimulation in primary cultured rat ventral horn spinal neurons and we have evaluated the possibility to limit the consequences of the hyperactivation of glutamatergic receptors, by recruiting the inhibitory transmission mediated by and |
3(0,0,0,3) | Details |
| 9021766 | Simpson RK Jr, Gondo M, Robertson CS, Goodman JC: Reduction in thermal hyperalgesia by intrathecal administration of and related compounds. Neurochem Res. 1997 Jan;22(1):75-9. Neuropathic rats created by unilateral partial ligation of the sciatic nerve were treated with intrathecal infusion of strychnine, MK-801, or 5-7 DKA at 0.1 mumol for 2 hours at a rate of 10 microliters/min. Administration of the NMDA receptor antagonist, MK-801, blocked the influence of with a less obvious antagonistic response from 5.7 DKA. |
2(0,0,0,2) | Details |
| 12611967 | Aguilar J, Rivadulla C, Soto C, Canedo A: New corticocuneate cellular mechanisms underlying the modulation of cutaneous ascending transmission in anesthetized cats. J Neurophysiol. 2003 Jun;89(6):3328-39. Epub 2003 Feb 26. Single unit extracellular records combined with iontophoresis showed that the corticocuneate input activates cuneo-lemniscal (CL) and noncuneo-lemniscal (nCL) cells via and non-NMDA receptors as shown by the decrease of the cortical-induced activation on ejection of CNQX and APV, either alone or in combination. Two subgroups of nCL cells were distinguished according to their sensitivity to iontophoretic ejection of and its antagonist, strychnine. |
2(0,0,0,2) | Details |
| 9061646 | Jiang ZG, Yang Y, Liu ZP, Allen CN: Membrane properties and synaptic inputs of suprachiasmatic nucleus neurons in rat brain slices. J Physiol. 1997 Feb 15;499 ( Pt 1):141-59. Stimulation of the optic nerve or chiasm usually evoked a monosynaptic EPSC which was mediated by both and non-NMDA receptors. The outward currents were blocked by bicuculline but not by strychnine, and were identified as IPSCs mediated by GABAA receptors. |
1(0,0,0,1) | Details |
| 11160487 | Terman GW, Eastman CL, Chavkin C: Mu opiates inhibit long-term potentiation induction in the spinal cord slice. J Neurophysiol. 2001 Feb;85(2):485-94. LTP of LT-evoked potentials depended on (NMDA) receptor activity, in that it was attenuated by the NMDA antagonist APV. Transverse slices were made from the lumbar spinal cord of 10- to 17-day-old rats, placed in a recording chamber, and perfused with artificial cerebrospinal fluid also containing bicuculline (10 microM) and strychnine (1 microM). |
1(0,0,0,1) | Details |
| 9153660 | Fu XW, Brezden BL, Kelly JB, Wu SH: Synaptic excitation in the dorsal nucleus of the lateral lemniscus: whole-cell patch-clamp recordings from rat brain slice. Neuroscience. 1997 Jun;78(3):815-27. The results indicate that both and non-N-methyl-D-aspartate receptor-mediated synaptic responses are present in dorsal nucleus of the lateral lemniscus neurons of rats at 21-35 days of age. To eliminate glycinergic inhibitory responses, all physiological data were gathered with 0.5 microM strychnine added to the saline bath. |
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| 11165805 | Branchereau P, Morin D, Bonnot A, Ballion B, Chapron J, Viala D: Development of lumbar rhythmic networks: from embryonic to neonate locomotor-like patterns in the mouse. Brain Res Bull. 2000 Nov 15;53(5):711-8. Bilateral activity became progressively alternate at E15 due to the appearance of glycinergic inhibitory interactions (revealed by strychnine application). Perfusion of receptor antagonists showed the co-operative involvement of - and non-NMDA-receptors for excitatory amino acids-mediated operation of locomotor networks. |
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| 10336086 | Petropoulos D, Lund JP, Dubuc R: A physiological study of brainstem and peripheral inputs to trigeminal motoneurons in lampreys. Neuroscience. 1999;91(1):379-89. These were significantly attenuated by adding 6-cyano-7-nitroquinoxaline2,3-dione (10 microM) and 2-amino-5-phosphonopentanoate (200 microM) to the bath, suggesting participation of both alpha-amino-3--5-methyl-4-isoxazolepropionate and N-methyl-D-aspartate receptors. |
1(0,0,0,1) | Details |
| 15159536 | Tsai G, Ralph-Williams RJ, Martina M, Bergeron R, Berger-Sweeney J, Dunham KS, Jiang Z, Caine SB, Coyle JT: Gene knockout of transporter 1: characterization of the behavioral phenotype. Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8485-90. Epub 2004 May 24. N-methyl-d-aspartate receptor (NMDAR) activation requires both the binding of to its recognition site and occupancy of the strychnine insensitive glycine modulatory site (GMS). |
1(0,0,0,1) | Details |
| 8939461 | Babcock KK, Chen X, Eggeman KT, Kumar KN, Decedue CJ, Michaelis EK: A synaptic membrane -, - and thienylcyclohexylpiperidine-binding protein: isolation and immunochemical characterization. Neurochem Int. 1996 Nov;29(5):507-19. Antibodies raised against a 43 kDa component of a complex of synaptic membrane proteins with ligand binding sites characteristic of / (NMDA) receptors, were used previously to clone a cDNA for a -, -, and thienylcyclohexylpirperidine (TCP)-binding protein, pGlyBP (Kumar et al., Biochem. The isolated fractions were highly enriched in strychnine-insensitive [3H] - and -sensitive L-[3H] and MK-801-sensitive [3H] TCP binding sites. |
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| 7893259 | Dimpfel W: Effects of memantine on synaptic transmission in the hippocampus in vitro. Arzneimittelforschung. 1995 Jan;45(1):1-5. The concentration dependent action of an agonist acting at the strychnine insensitive -site of the receptor was enhanced in the presence of 1 mumol/l of memantine. These effects of memantine were antagonized completely by very low concentrations of the selective non-NMDA receptor antagonist NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzoe (F) quinoxyline) as well as by less selective antagonists such as DNQX (6,7-dinitroquinoxaline-2,3-dione) and CNQX (6-cyano-7-nitroquinoxaline-2,3-dione). |
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| 11692754 | Mothet JP: Physiological relevance of endogenous free in the mammalian brain: are scientists on a royal road for the treatment of glutamatergic-related brain disorders?. Pathol Biol. 2001 Oct;49(8):655-9. In this review, we focus on recent findings regarding the physiological relevance of a new neurotransmitter formed in glial cells, that serves as the endogenous ligand for the accessory strychnine-insensitive site of the subtype of glutamate receptors. |
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| 18675825 | Witkin JM, Baez M, Yu J, Eiler WJ 2nd: mGlu5 receptor deletion does not confer seizure protection to mice. Life Sci. 2008 Aug 29;83(9-10):377-80. Epub 2008 Jul 15. Chemically induced seizures induced by a variety of mechanisms including pentylenetetrazole, cocaine, kainic acid, 4-aminopyridine, strychnine, and did not differentially increase clonic, clonic/tonic, or lethality in WT vs. mGlu5 receptor KO mice. |
0(0,0,0,0) | Details |
| 9426842 | Bienkowski P, Danysz W, Kostowski W: Study on the role of strychnine-insensitive receptors (glycineB sites) in the discriminative stimulus effects of in the rat. Alcohol. 1998 Jan;15(1):87-91. In the present study we examined compounds from another class of NMDA receptor antagonists-- strychnine-insensitive, receptor (glycineB site) antagonists in rats trained to discriminate between i.p.-administered 1.0 g/kg (10% v/v) and saline. |
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| 8242398 | Layer RT, Bland LR, Skolnick P: MK-801, but not drugs acting at strychnine-insensitive glycine receptors, attenuate methamphetamine nigrostriatal toxicity. Brain Res. 1993 Oct 15;625(1):38-44. The objectives of the present study were to examine whether comparable reductions in METH-induced damage could be obtained by compounds acting at strychnine-insensitive glycine receptors on the NMDA receptor complex. |
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| 10360746 | Cordi A, Lacoste JM, Audinot V, Millan M: Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands. Bioorg Med Chem Lett. 1999 May 17;9(10):1409-14. The in vitro activities of 3--imidazolidin-4-one derivatives demonstrated very restricted structure-activity relationships at the strychnine-insensitive site of the NMDA receptor. |
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| 11698519 | Matsui K, Hasegawa J, Tachibana M: Modulation of excitatory synaptic transmission by (C) receptor-mediated feedback in the mouse inner retina. J Neurophysiol. 2001 Nov;86(5):2285-98. In many vertebrate CNS synapses, the neurotransmitter activates postsynaptic non- and NMDA receptors. ON-transient amacrine cells were whole cell voltage-clamped, and the glutamatergic synaptic input from bipolar cells was isolated by a cocktail of pharmacological agents (bicuculline, strychnine, curare, and atropine). |
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| 8883856 | Matsuoka N, Aigner TG: The /NMDA receptor antagonist HA-966 impairs visual recognition memory in rhesus monkeys. Brain Res. 1996 Aug 26;731(1-2):72-8. Recent studies have shown that strychnine-insensitive binding sites positively modulate the N-methyl-D-asparate subclass of glutamate receptors, which are important in neural pathways involved in cognitive function. |
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| 8169857 | Paul IA, Nowak G, Layer RT, Popik P, Skolnick P: Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. J Pharmacol Exp Ther. 1994 Apr;269(1):95-102. Chronic (14 day) but not acute (1 day) treatment of mice with clinically active antidepressants produces a significant (approximately 1.8-4.3 fold) reduction in the potency of to inhibit [3H]-5,7-dichlorkynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine receptors in neocortical membranes. |
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| 9264101 | Decollogne S, Tomas A, Lecerf C, Adamowicz E, Seman M: NMDA receptor complex blockade by oral administration of comparison with MK-801. Pharmacol Biochem Behav. 1997 Sep;58(1):261-8. An anticonvulsant effect of Mg2+ treatment is also observed with strychnine-induced convulsions but not with bicuculline-, picrotoxin-, or pentylenetetrazol-induced convulsions. |
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| 11784734 | Svensson E, Grillner S, Parker D: Synaptically evoked membrane potential oscillations induced by substance P in lamprey motor neurons. J Neurophysiol. 2002 Jan;87(1):113-21. The oscillations were abolished or reduced by the AMPA/kainate receptor antagonist 6-cyano-7-nitroquinoxalene-2,3-dione but were only reduced by the NMDA receptor antagonist D-AP5. Blocking glycinergic inputs with strychnine resulted in large depolarizing plateaus and bursts of spikes. |
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| 9083472 | Di Fabio R, Capelli AM, Conti N, Cugola A, Donati D, Feriani A, Gastaldi P, Gaviraghi G, Hewkin CT, Micheli F, Missio A, Mugnaini M, Pecunioso A, Quaglia AM, Ratti E, Rossi L, Tedesco G, Trist DG, Reggiani A: Substituted -2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive binding site. J Med Chem. 1997 Mar 14;40(6):841-50. According to these results the terminal phenyl ring of the C-3 side chain should lie in a nonhydrophobic pocket of limited size, refining the proposed pharmacophore model of the binding site associated with the NMDA receptor. |
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| 7623156 | Zhou ZJ, Fain GL: Neurotransmitter receptors of starburst amacrine cells in rabbit retinal slices. J Neurosci. 1995 Jul;15(7 Pt 2):5334-45. The I/V relation of the -evoked response showed a characteristic "J"-shaped region in a saline containing 1 mM Mg2+ and 0 Cd2+, indicating that NMDA receptors were present directly on starburst cells. (30-200 microM) also activated a Cl- conductance in starburst cells, which could be completely blocked by strychnine. |
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| 11785914 | Borowicz KK: Effect of antihormones in amygdala-kindled seizures in rats. Pol J Pharmacol. 2001 Jan-Feb;53(1):61-3. Also the augmentation of glutamatergic transmission, realized through NMDA receptors, may be involved in the mechanism of antiseizure action of TXF and CYP. The interaction between antihormones and carbamazepine, or phenobarbital, was not reversed by the respective gonadal hormones and kainic acid, or strychnine. |
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| 11134626 | Zhong J, Gerber G, Kojic L, Randic M: Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn. Brain Res. 2000 Dec 29;887(2):359-77. The effects of on monosynaptic and polysynaptic EPSPs were reduced, or abolished, by the (NMDA) receptor antagonist D (-)-2-amino-5-phosphonopentanoic acid (AP5). |
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| 7971741 | Bartlett SE, Dodd PR, Smith MT: Pharmacology of morphine and morphine-3- at opioid, excitatory amino acid, and binding sites. Pharmacol Toxicol. 1994 Aug;75(2):73-81. In addition, morphine-3- and morphine did not inhibit the binding of 3H-strychnine (glycine receptor antagonist) to synaptic membranes prepared from bovine spinal cord. |
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| 11224288 | Smith RD, Grzelak ME, Coffin VL: Felbamate, a novel antiepileptic agent, does not affect cognition in rodents. Behav Pharmacol. 1994 Jun;5(3):365-368. While the mechanism of action of felbamate has not been fully eludicated, recent evidence has accumulated to suggest that felbamate may act at the strychnine-insensitive binding site on the NMDA receptor complex. |
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| 7796152 | Newell DW, Barth A, Malouf AT: site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures. Brain Res. 1995 Mar 27;675(1-2):38-44. Ischemia-induced neuronal injury can be reduced by antagonists acting at the (NMDA) receptor. 7-Chlorokynurenic acid and the recently synthesized compound Acea 1021 block NMDA receptors by acting at the strychnine-insensitive site. |
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| 19268504 | Papiez MA, Dybala M, Sowa-Kucma M, Krzysciak W, Taha H, Jozkowicz A, Nowak G: Evaluation of oxidative status and depression-like responses in Brown Norway rats with acute myeloid leukemia. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):596-604. Epub 2009 Mar 3. A significant increase in the potency of to displace [(3) H] L-689,560 from the strychnine-insensitive site of the N-methyl-D-aspartic (NMDA) receptors receptor complex in cortical homogenates of the leukemic rats in 30- and 34-day experimental series was observed in comparison with the control. |
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| 8183425 | Norris DO, Mastropaolo J, O'Connor DA, Cohen JM, Deutsch SI: A glycinergic intervention potentiates the antiseizure efficacies of MK-801, flurazepam, and carbamazepine. Neurochem Res. 1994 Feb;19(2):161-5. D-cycloserine, a partial agonist with greater specificity for the strychnine-insensitive modulatory site on the NMDA receptor complex, was examined for its effect on MK-801's antiseizure efficacy. |
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| 12429224 | Wu HQ, Lee SC, Scharfman HE, Schwarcz R: L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat. Exp Neurol. 2002 Sep;177(1):222-32. Blockade of the strychnine-insensitive site of the NMDA receptor is considered an attractive strategy for the development of novel neuroprotective and anticonvulsive agents. 7-Cl- (7-Cl-KYNA) is a potent, selective antagonist of the /glycine receptor but penetrates poorly through the blood-brain barrier. |
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| 9814546 | Calderon F, Lopez-Colome AM: inhibits [3H] binding at the NMDA receptors from plexiform layers of chick retina. Neurochem Res. 1998 Nov;23(11):1363-9. Strychnine-insensitive [3H] binding was inhibited by 100 microM due to a reduction in Bmax (P1 = 0.84 +/- 0.16 pmol/mg protein; P2 = 0.81 +/- 0.16 pmol/mg protein) without affecting the Kd. |
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| 14642785 | Jha A, Deshpande SB: Aglycemia and ischemia depress spinal synaptic transmission via inhibitory systems involving NMDA receptors. Eur J Pharmacol. 2003 Nov 28;481(2-3):189-96. Strychnine (A) receptor antagonist) or bicuculline (A) receptor antagonist) blocked the aglycemia-induced depression of the reflexes. |
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| 10634876 | Gibson IC, Berger AJ: Effect of upon respiratory-related hypoglossal nerve output of neonatal rat brain stem slices. J Neurophysiol. 2000 Jan;83(1):333-42. Application of either strychnine (5 microM) or bicuculline (5 microM) alone, partially but not significantly, reversed the inhibition of respiratory-related hypoglossal nerve activity produced by 50 mM EtOH. Preincubation of the slices with 25 microM APV reduced the relative degree of inhibition caused by EtOH suggesting that (NMDA)-receptor-mediated events can be affected by EtOH. |
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| 7884467 | Pinco M, Lev-Tov A: Synaptic transmission between ventrolateral funiculus axons and lumbar motoneurons in the isolated spinal cord of the neonatal rat. J Neurophysiol. 1994 Nov;72(5):2406-19. Suppression of the excitatory components of VLF postsynaptic potentials (PSPs) by application of the specific antagonists of and non-NMDA receptors, 2-amino-5-phosphonovaleric acid (APV) and 6-cyano-7-nitroquin-oxaline-2,3-dione (CNQX), revealed depolarizing PSPs that could be reversed at -55 to -60 mV by injection of depolarizing current steps to the motoneurons. These depolarizing PSPs were blocked by addition of strychnine and bicuculline and are therefore suggested to be and -A (GABAA) receptor-mediated inhibitory PSPs. |
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| 14530208 | Rouaud E, Billard JM: D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices. Br J Pharmacol. 2003 Nov;140(6):1051-6. Epub 2003 Oct 6. The -binding site of the glutamatergic N-methyl-d-aspartate receptor subtype (NMDAr) has been proposed as a putative target for treating cognitive impairments in neurodegenerative disorders and schizophrenia. This inhibition was not prevented by the GABAA antagonist bicuculline, but was antagonized by the antagonist strychnine. 4. |
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| 15182308 | Soto C, Aguilar J, Martin-Cora F, Rivadulla C, Canedo A: Intracuneate mechanisms underlying primary afferent cutaneous processing in anaesthetized cats. Eur J Neurosci. 2004 Jun;19(11):3006-16. The involvement of NMDA receptors was confirmed by in vivo intracellular recordings. The cutaneous-evoked activation of CL cells was decreased by and increased by acting at a strychnine-sensitive site, indicating that indirectly affects CL cells. |
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| 14575889 | Li GL, Yang XL: Glycinergic input to carp retinal ganglion cells may be mediated by glycine receptors with homologous kinetics. Brain Res. 2003 Nov 21;991(1-2):171-9. Strychnine (1 microM), a glycine receptor antagonist, completely blocked the response to 100 microM Moreover, Zn (2+) exerted similar dual action on this sustained response and the response in Ringer's: potentiating and reducing them at low and high concentrations of Zn (2+), respectively. 5,7-Dichlorokynurenic acid (DCKA, 500 microM), a selective blocker of the recognition site at the NMDA receptor, partially reduced the response, but without changing its kinetics. |
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| 16645195 | Orer HS, Gebber GL, Barman SM: Medullary lateral tegmental field neurons influence the timing and pattern of phrenic nerve activity in cats. J Appl Physiol. 2006 Aug;101(2):521-30. Epub 2006 Apr 27. Second, blockade of non-NMDA receptors significantly reduced I-burst amplitude without affecting central respiratory rate. |
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| 19826900 | Hernandes MS, Troncone LR: as a neurotransmitter in the forebrain: a short review. J Neural Transm. 2009 Dec;116(12):1551-60. Epub 2009 Oct 14. The description of its involvement in the mechanism of action of the potent neurotoxin strychnine pushed further the concept of inhibitory transmitter. This review encompasses a few of these aspects as the role of the different glycine receptors (GlyRs) in intracellular balance, transporters, / co-release, /NMDA receptor interaction, glycine receptors in acute effects and advocates a more relevant role for as a stimulatory transmitter in forebrain areas. |
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| 18171925 | Sanchez JT, Gans D, Wenstrup JJ: Glycinergic "inhibition" mediates selective excitatory responses to combinations of sounds. J Neurosci. 2008 Jan 2;28(1):80-90. In nearly all neurons for which the GlyR antagonist strychnine was applied in addition to iGluR blockade (22 of 23 neurons, with or without (A) R blockade), facilitatory interactions were eliminated. |
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| 7700536 | Luque JM, Nelson N, Richards JG: Cellular expression of transporter 2 messenger RNA exclusively in rat hindbrain and spinal cord. Neuroscience. 1995 Jan;64(2):525-35. Moreover, adjacent series of sections were labelled with [3H] strychnine to reveal the regional distribution of strychnine-sensitive glycine receptors. |
0(0,0,0,0) | Details |
| 7472497 | Sernagor E, Chub N, Ritter A, O'Donovan MJ: Pharmacological characterization of the rhythmic synaptic drive onto lumbosacral motoneurons in the chick embryo spinal cord. J Neurosci. 1995 Nov;15(11):7452-64. The pause in sartorius firing was shortened following local application of the antagonist strychnine the nicotinic, cholinergic antagonists mecamylamine, and dihydro-beta-erythroidine and several excitatory amino acid antagonists. |
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| 15275654 | Ruggieri RD, Pierobon P, Kass-Simon G: Pacemaker activity in hydra is modulated by glycine receptor ligands. . Comp Biochem Physiol A Mol Integr Physiol. 2004 Jun;138(2):193-202. In the mammalian central nervous system, the neurotransmitter, acts both on an inhibitory, strychnine-sensitive receptor (GlyR) and an excitatory, strychnine-insensitive site at the NMDA receptor. |
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| 7817791 | Saransaari P, Oja SS: Characterization of -independent binding to cerebral cortical membranes from 7-day-old and adult mice. Int J Dev Neurosci. 1994 Aug;12(5):491-7. It is concluded that even though may possess binding sites of its own, particularly in the immature cerebral cortex, could at least partly bind to strychnine-insensitive sites in the N-methyl-D-aspartate receptor complex. |
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| 7588967 | Tegtmeyer-Metzdorf H, Roth B, Gunther M, Theisohn M, Heinemann U, Adams HA, Sticht G: Ketamine and strychnine treatment of an infant with nonketotic hyperglycinaemia. Eur J Pediatr. 1995 Aug;154(8):649-53. Based on this knowledge we treated a female newborn suffering from severe NKH with the NMDA receptor blocker ketamine in association with strychnine and supplementation. |
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| 7595597 | Rodriguez-Ithurralde D, Olivera S, Migues V, Vincent O, Salazar R: Glutamate-receptor elicited acetylcholinesterase release in mouse spinal cord slice: a model of early excitotoxic injury. J Neurol Sci. 1995 May;129 Suppl:104-6. In the immature slice, potentiated GLU elicited AChE release in the presence of strychnine, suggesting (NMDA) receptor involvement. |
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| 8836233 | Hartveit E: Membrane currents evoked by ionotropic glutamate receptor agonists in rod bipolar cells in the rat retinal slice preparation. J Neurophysiol. 1996 Jul;76(1):401-22. The conductance increase evoked by non-NMDA receptor agonists could not be blocked by a combination of 100 microM picrotoxin and 10 microM strychnine. Pressure application of the non- (non-NMDA) receptor agonists kainate and (S)-alpha-amino-3--5-methyl-4-isoxazolepropionic acid (AMPA) from puffer pipettes evoked a long-latency conductance increase selective for ions. |
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| 7562904 | Bigge CF, Malone TC, Boxer PA, Nelson CB, Ortwine DF, Schelkun RM, Retz DM, Lescosky LJ, Borosky SA, Vartanian MG, et al.: Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido [3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3--5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity. J Med Chem. 1995 Sep 15;38(19):3720-40. The compounds were tested for their affinity to the AMPA, kainate, and strychnine-insensitive glycine receptor sites. |
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| 7865167 | Kretschmer BD, Winterscheid B, Danysz W, Schmidt WJ: site antagonists abolish D2 but not D1 receptor mediated catalepsy in rats. J Neural Transm Gen Sect. 1994;95(2):123-36. This finding is surprising, since NMDA receptor antagonists counteract both, D 1 and D 2 receptor mediated catalepsy. |
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| 7666201 | Lukasiewicz PD, Lawrence JE, Valentino TL: Desensitizing glutamate receptors shape excitatory synaptic inputs to tiger salamander retinal ganglion cells. J Neurosci. 1995 Sep;15(9):6189-99. The AMPA/KA receptor-mediated component of the EPSCs was isolated by including NMDA receptor antagonists in the bath. Strychnine and picrotoxin blocked inhibitory inputs. |
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| 18256163 | Biesdorf S, Malinvaud D, Reichenberger I, Pfanzelt S, Straka H: Differential inhibitory control of semicircular canal nerve afferent-evoked inputs in second-order vestibular neurons by glycinergic and GABAergic circuits. J Neurophysiol. 2008 Apr;99(4):1758-69. Epub 2008 Feb 6. The increase in monosynaptic excitation after a block of the disynaptic inhibition in phasic 2 degrees VN is in part mediated by a N-methyl-d-aspartate receptor-activated component. |
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| 15746915 | Gillespie DC, Kim G, Kandler K: Inhibitory synapses in the developing auditory system are glutamatergic. Nat Neurosci. 2005 Mar;8(3):332-8. Epub 2005 Jan 30. We provide evidence that immature /glycinergic synapses in the rat LSO also release the excitatory neurotransmitter which activates postsynaptic NMDA receptors (NMDARs). |
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| 8223944 | Johansen TH, Drejer J, Watjen F, Nielsen EO: A novel non-NMDA receptor antagonist shows selective displacement of low-affinity [3H] kainate binding. Eur J Pharmacol. 1993 Aug 15;246(3):195-204. 5-Nitro-6,7,8,9-tetrahydrobenzo [G] -2,3-dione-3-oxime (NS-102), a new competitive glutamate receptor antagonist displaced binding to non- (non- binding sites with no activity at the and strychnine-insensitive binding sites. |
1(0,0,0,1) | Details |
| 8103091 | Zhou ZJ, Fain GL, Dowling JE: The excitatory and inhibitory amino acid receptors on horizontal cells isolated from the white perch retina. J Neurophysiol. 1993 Jul;70(1):8-19. The ratio of the amplitude of responses to GLU, KA, QUIS, and AMPA remained nearly constant among all the horizontal cells tested, suggesting there might be only a single population of non-NMDA receptors on these cells. 8. GLY-activated currents were inhibited by the glycine receptor antagonist strychnine (STRYCH). |
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| 14984403 | Legrand JC, Darbon P, Streit J: Contributions of NMDA receptors to network recruitment and rhythm generation in spinal cord cultures. Eur J Neurosci. 2004 Feb;19(3):521-32. |
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| 19619564 | Zhang HX, Lyons-Warren A, Thio LL: The transport inhibitor is an inhibitory glycine receptor agonist. Neuropharmacology. 2009 Oct-Nov;57(5-6):551-5. Epub 2009 Jul 18. is an endogenous amino acid that is a competitive inhibitor of the type I transporter (GlyT1), an N-methyl-d-aspartate receptor (NMDAR) co-agonist, and an important intermediate in one-carbon metabolism. We examined this possibility using whole-cell recordings from cultured embryonic mouse hippocampal neurons and found that evoked a dose-dependent, strychnine sensitive, Cl (-) current that cross-inhibited currents. |
1(0,0,0,1) | Details |
| 14585753 | Kurup RK, Kurup PA: A hypothalamic -mediated model for autism. . Int J Neurosci. 2003 Nov;113(11):1537-59. excitotoxicity could result from hypomagnesemia induced by membrane Na+-K+ ATPase inhibition and an agonist acting on the NMDA receptor. can also preferentially upregulate transport over resulting in increased levels of depolarizing catabolites-- agonist), strychnine (blocks glycinergic inhibitory transmission), and (promotes release) and decreased levels of hyperpolarizing catabolites-- and morphine--contributing to membrane Na+-K+ ATPase inhibition. |
1(0,0,0,1) | Details |
| 9786501 | Platt B, Bate JR, von Linstow Roloff E, Withington DJ: induces a novel form of long-term potentiation in the superficial layers of the superior colliculus. Br J Pharmacol. 1998 Sep;125(2):293-300. LTPgly could only be masked but not prevented by strychnine (100 microM) and remained undisturbed in the presence of picrotoxin (100 microM). 5. |
0(0,0,0,0) | Details |
| 8624016 | Onaka M, Minami T, Nishihara I, Ito S: Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice. Anesthesiology. 1996 May;84(5):1215-22. |
0(0,0,0,0) | Details |
| 7513639 | Macdonald RL, Kelly KM: Mechanisms of action of currently prescribed and newly developed antiepileptic drugs. Epilepsia. 1994;35 Suppl 4:S41-50. The antiepileptic effect of felbamate may involve interaction at the strychnine-insensitive site of the N-methyl-D-aspartate receptor, but the mechanism of action is not yet proven. |
0(0,0,0,0) | Details |
| 7812607 | Saitoh T, Ishida M, Maruyama M, Shinozaki H: A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70. |
0(0,0,0,0) | Details |
| 9085718 | Beleslin DB, Djokanovic N, Jovanovic Micic D, Samardzic R: Opposite effects of GABAA and NMDA receptor antagonists on -induced behavioral sleep in rats. Alcohol. 1997 Mar-Apr;14(2):167-73. The effects of the GABAA receptor antagonists, pentylenetetrazol, bicuculline, and picrotoxin, the antagonist, strychnine, and the NMDA receptor antagonist, memantine, on -induced behavioral sleep and body temperature were investigated. |
32(0,1,1,2) | Details |
| 7813551 | Long JB, Skolnick P: 1-Aminocyclopropanecarboxylic acid protects against dynorphin A-induced spinal injury. Eur J Pharmacol. 1994 Aug 22;261(3):295-301. The protective effects of a variety of competitive and non-competitive (NMDA) receptor antagonists indicate that activation of the NMDA receptor complex is essential for dynorphin A-induced spinal cord injury. 1-Aminocyclopropanecarboxylic acid (ACPC) is a high affinity, partial agonist at strychnine-insensitive glycine receptors associated with the NMDA receptor complex. |
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| 8953423 | Bum EN, Meier CL, Urwyler S, Wang Y, Herrling PL: Extracts from rhizomes of Cyperus articulatus (Cyperaceae) displace [3H] CGP39653 and [3H] binding from cortical membranes and selectively inhibit NMDA receptor-mediated neurotransmission. J Ethnopharmacol. 1996 Nov;54(2-3):103-11. One or several component (s) contained in the extracts inhibited the binding of [3H] CGP39653 to the recognition site and of [3H] to the strychnine-insensitive site of the NMDA receptor complex from rat neocortex. |
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| 8052412 | Saransaari P, Oja SS: Regulation of D- release by and GABA receptors in cerebral cortical slices from developing and ageing mice. Neuroscience. 1994 May;60(1):191-8. The effect was strychnine-insensitive, characteristic of the modulatory site in the N-methyl-D-aspartate receptor. |
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| 8103090 | Pinco M, Lev-Tov A: Synaptic excitation of alpha-motoneurons by dorsal root afferents in the neonatal rat spinal cord. J Neurophysiol. 1993 Jul;70(1):406-17. The duration of monosynaptic excitatory postsynaptic potentials (EPSPs) elicited in lumbar motoneurons were shortened after addition of the specific (NMDA) receptor blocker 2-amino-5-phosphonovaleric acid (APV) to the perfusate. Polysynaptic EPSPs evoked in motoneurons in the fifth lumbar segment by stimulation of the fourth lumbar dorsal root in the presence of the and A (GABAA) receptor blockers strychnine and bicuculline could be completely or partially blocked by application of either APV or CNQX. |
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| 9257903 | Jin S, Fredholm BB: Electrically-evoked and release from rat striatal slices perfused without regulation by acting on NMDA receptors. Br J Pharmacol. 1997 Aug;121(7):1269-76. In addition, increased the evoked release of [3H]- via a site inhibitable by strychnine (1 microM). 3. |
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| 15356198 | Carpenter-Hyland EP, Woodward JJ, Chandler LJ: Chronic induces synaptic but not extrasynaptic targeting of NMDA receptors. J Neurosci. 2004 Sep 8;24(36):7859-68. The present study used confocal imaging and electrophysiology procedures to assess the effects of prolonged exposure on NMDA receptor trafficking in cultures of hippocampal neurons. |
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| 11860460 | Pierobon P, Minei R, Porcu P, Sogliano C, Tino A, Marino G, Biggio G, Concas A: Putative glycine receptors in Hydra: a biochemical and behavioural study. Eur J Neurosci. 2001 Nov;14(10):1659-66. a agonist at the vertebrate NMDA receptor, produced opposite effects to those of Saturation experiments revealed the occurrence of one population of binding sites of nanomolar affinity (KD = 33 nm) and low capacity (Bmax = 79 fmol/mg protein) for [(3) H] strychnine. |
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| 7498252 | Kretschmer BD, Bubser M, Schmidt WJ: Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur J Pharmacol. 1995 Jun 23;280(1):37-45. The present study investigated if blockade of the modulatory glycine receptor of the NMDA receptor complex influences the expression of behavior (sniffing stereotypy and locomotion) and metabolism in rats as it has been shown for NMDA receptor antagonists. |
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| 12183673 | Martin G, Siggins GR: Electrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens. J Pharmacol Exp Ther. 2002 Sep;302(3):1135-45. The current was not blocked by 200 microM picrotoxin and 10 microM zinc, was weakly antagonized by 1 microM strychnine, and was not enhanced by 1 microM zinc. In the course of studying (NMDA) receptors of the nucleus accumbens (NAcc), we found that 20% of freshly isolated medium spiny neurons, as well as all interneurons, responded in an unexpected way to long (5-s) coapplication of and the coagonist of NMDA receptors. |
1(0,0,0,1) | Details |
| 9236256 | Sandkuhler J, Chen JG, Cheng G, Randic M: Low-frequency stimulation of afferent Adelta-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat. J Neurosci. 1997 Aug 15;17(16):6483-91. Bath application of the GABAA receptor antagonist bicuculline and glycine receptor antagonist strychnine did not affect LTD. When NMDA receptors were blocked by bath application of D-2-amino-5-phosphonovaleric acid, LTD was abolished or strongly reduced. |
1(0,0,0,1) | Details |
| 10718744 | Galante M, Nistri A, Ballerini L: Opposite changes in synaptic activity of organotypic rat spinal cord cultures after chronic block of AMPA/kainate or and GABAA receptors. J Physiol. 2000 Mar 15;523 Pt 3:639-51. Spontaneous or electrically evoked currents acquired a larger component mediated by NMDA receptor activity. 7. Spontaneous or electrically evoked synaptic transmission of patch-clamped ventral horn interneurons was studied in control solution after blocking, for the second week in culture, AMPA/kainate receptors with CNQX or and GABAA receptors with strychnine and bicuculline, or indiscriminately removing inputs with tetrodotoxin (TTX). 3. |
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| 9447684 | Velte TJ, Yu W, Miller RF: Estimating the contributions of and non- currents to EPSPs in retinal ganglion cells. Vis Neurosci. 1997 Nov-Dec;14(6):999-1014. Separation of and KA/AMPA excitatory postsynaptic currents (EPSCs) was achieved through the application of the antagonists NBQX and D-AP7, while inhibitory currents were blocked by strychnine and picrotoxin. |
0(0,0,0,0) | Details |
| 11516417 | Su CK: Intraspinal amino acid neurotransmitter activities are involved in the generation of rhythmic sympathetic nerve discharge in newborn rat spinal cord. Brain Res. 2001 Jun 15;904(1):112-25. In contrast, strychnine (Stry, glycine receptor antagonist) consistently reduced qSND in a dose-dependent manner. |
0(0,0,0,0) | Details |
| 8391982 | Swinyard EA, Wolf HH, White HS, Skeen GA, Stark LG, Albertson T, Pong SF, Drust EG: Characterization of the anticonvulsant properties of F-721. Epilepsy Res. 1993 May;15(1):35-45. F-721 exhibited only partial activity against clonic seizures induced in the subcutaneous Metrazol and subcutaneous bicuculline test in mice and was inactive in this species against tonic seizures induced in the subcutaneous strychnine test. |
0(0,0,0,0) | Details |
| 8015346 | Miller GW, Schnellmann RG: A putative cytoprotective receptor in the kidney: relation to the neuronal strychnine-sensitive glycine receptor. Life Sci. 1994;55(1):27-34. |
0(0,0,0,0) | Details |
| 20060035 | Gemba-Nishimura A, Inoue T, Nakamura S, Nakayama K, Mochizuki A, Shintani S, Yoshimura S: Properties of synaptic transmission from the reticular formation dorsal to the facial nucleus to trigeminal motoneurons during early postnatal development in rats. Neuroscience. 2010 Mar 31;166(3):1008-22. Epub 2010 Jan 6. Combined bath application of the non- (non-NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), and the NMDA receptor antagonist DL-2-amino-5-phosphonopentanoic acid (APV) reduced these optical responses, and addition of the glycine receptor antagonist strychnine and the (A) receptor antagonist bicuculline further reduced the remaining responses. |
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| 17432963 | Rutter AR, Fradley RL, Garrett EM, Chapman KL, Lawrence JM, Rosahl TW, Patel S: Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS. Eur J Neurosci. 2007 Mar;25(6):1757-66. In the mammalian central nervous system, transporter-mediated reuptake may be critical for terminating the neurotransmitter action of at the strychnine insensitive site of the NMDA receptor. |
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| 9622453 | Darstein M, Albrecht C, Lopez-Francos L, Knorle R, Holter SM, Spanagel R, Feuerstein TJ: Release and accumulation of neurotransmitters in the rat brain: acute effects of in vitro and effects of long-term voluntary intake. Alcohol Clin Exp Res. 1998 May;22(3):704-9. Slices of the rat caudatoputamen were prelabeled with [3H] and release of [3H] was stimulated through either (NMDA) receptors or strychnine-sensitive glycine receptors. |
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| 9453115 | Tomiyama M, Kannari K, Matsunaga M: Strychnine-sensitive and strychnine-insensitive binding sites in the spinal cord of the wobbler mouse. Tohoku J Exp Med. 1997 Sep;183(1):37-43. Using quantitative autoradiography, the strychnine-sensitive site and strychnine-insensitive site of the N-methyl-D-aspartate receptor were analyzed in the cervical segment of the spinal cord of the wobbler mouse, which is a purported model of human motor neuron diseases. |
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| 9178845 | O'Brien JA, Isaacson JS, Berger AJ: and non-NMDA receptors are co-localized at excitatory synapses of rat hypoglossal motoneurons. Neurosci Lett. 1997 May 9;227(1):5-8. |
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| 7961649 | Kumar KN, Babcock KK, Johnson PS, Chen X, Eggeman KT, Michaelis EK: Purification and pharmacological and immunochemical characterization of synaptic membrane proteins with ligand-binding properties of N-methyl-D-aspartate receptors. J Biol Chem. 1994 Nov 4;269(44):27384-93. The co-purification of -sensitive binding, dizocilpine-sensitive thienylcyclohexyl piperidine (TCP)-binding, and strychnine-insensitive -binding proteins was achieved by this affinity chromatographic procedure. |
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| 9209115 | Jenei Z, Varga V, Janaky R, Saransaari P, Oja SS: Role of histidyl residues in the binding of ligands to the porcine N-methyl-D-aspartate receptor. Neurosci Lett. 1997 Jun 6;228(2):127-30. DEPC reduced the strychnine-insensitive binding of [3H] and the - and -activated binding of [3H] dizocilpine. |
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| 8350653 | Saransaari P, Oja SS: Phencyclidine-binding sites in mouse cerebral cortex during development and ageing: effects of inhibitory amino acids. Mech Ageing Dev. 1993 May;68(1-3):125-36. The binding of N-[1-(2-thienyl) cyclohexyl]-[3H] piperidine ([3H] TCP) to the phencyclidine-binding sites in the (NMDA) receptor complex-associated ion channel was characterized in cerebral cortical membranes from 3-day-old to 24-month-old mice. The general properties of the binding; potentiation by and as well as by in a strychnine-insensitive manner, prevailed during development and ageing, certain of these effects being however less pronounced in the immature brain. |
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| 11283224 | Akopian A, Witkovsky P: Intracellular reduces light-induced excitatory post-synaptic responses in salamander retinal ganglion cells. J Physiol. 2001 Apr 1;532(Pt 1):43-53. Both AMPA and NMDA receptors contributed to the light-evoked responses. In the presence of strychnine and picrotoxin, ganglion cells responded to light onset and offset with transient inward currents at -70 mV. |
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| 11445185 | Jones MW, McClean M, Parsons CG, Headley PM: The in vivo relevance of the varied channel-blocking properties of uncompetitive antagonists: tests on spinal neurones. Neuropharmacology. 2001 Jul;41(1):50-61. The voltage dependence and channel-blocking kinetics of uncompetitive NMDA receptor antagonists have been well-described using in vitro techniques, but there is little evidence concerning the functional significance of these properties in vivo. The compounds examined were the uncompetitive channel blockers memantine, ketamine and MK-801 and, for comparison, an antagonist that acts at the strychnine-insensitive binding site (MRZ 2/502). |
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| 10218805 | Xiao J, Wang Y, Wang SR: Effects of glutamatergic, cholinergic and gabaergic antagonists on tectal cells in toads. Neuroscience. 1999 Mar;90(3):1061-7. Visual responses in 80% of tectal cells were reversibly blocked by the antagonist 3-Rs-2-carboxypiperazin-4-yl-propyl-1-phosphonic acid, and those of the remaining 20% of cells by the muscarinic antagonist atropine, suggesting that there may be at least two kinds of retinotectal synapse that use and N-methyl-D-aspartate receptors, and and muscarinic receptors, respectively. The excitatory responses were reversibly abolished by atropine, but not affected by either 3-Rs-2-carboxypiperazin-4-yl-propyl-1-phosphonic acid or the alpha-amino-3--5-methyl-4-isoxazole- antagonist 6-cyano-7-nitroquinoxaline-2,3-dione, whereas the inhibitory responses were released by the GABA receptor A antagonist bicuculline, but not influenced by the GABA receptor B antagonist 2-hydroxysaclofen and glycinergic antagonist strychnine. |
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| 9427337 | Kapoor R, Okuno E, Kido R, Kapoor V: Immuno-localization of aminotransferase (KAT) in the rat medulla and spinal cord. Neuroreport. 1997 Nov 10;8(16):3619-23. In the mammalian brain, kynurenine aminotransferase (KAT) is pivotal to the synthesis of a preferential antagonist at the strychnine-insensitive - site. As NMDA receptors are involved in autonomic function, we have examined the immunohistochemical localization of KAT in the medulla and spinal cord of the rat. |
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| 15744010 | Baptista V, Varanda WA: binding site of the synaptic NMDA receptor in subpostremal NTS neurons. J Neurophysiol. 2005 Jul;94(1):147-52. Epub 2005 Mar 2. increased the conductance of the postsynaptic membrane, without altering its reversal potential, both in the presence (from 2.4 +/- 0.06 to 3.4 +/- 0.09 nS; n = 7) and absence (from 3.1 +/- 0.06 to 4.4 +/- 0.10 nS; n = 8) of Mg2+ in the bathing solution. in the presence of strychnine, also increased the amplitude of the component (by 68 +/- 19%, P < 0.05, n = 5). |
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| 15655532 | Li HF, Mochly-Rosen D, Kendig JJ: Protein kinase Cgamma mediates withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons. Br J Pharmacol. 2005 Feb;144(3):301-7. Postsynaptic currents were evoked by brief pulses of 2 mM in the presence of bicuculline methiodide 10 microM; strychnine 5 microM and tetrodotoxin 0.5 microM. |
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| 18930740 | Gupta R, Deshpande SB: 3-Nitropropionic acid depresses spinal reflexes involving GABAergic and glycinergic transmission in neonatal rat spinal cord in vitro. Life Sci. 2008 Nov 21;83(21-22):756-60. Epub 2008 Oct 5. Superfusion of bicuculline (GABAA receptor antagonist; 1 microM), or strychnine (glycineA receptor antagonist; 1 microM) antagonized the 3-NPA-induced depression of reflexes significantly. |
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| 17346892 | Ge LH, Lee SC, Liu J, Yang XL: Glycine receptors are functionally expressed on bullfrog retinal cone photoreceptors. Neuroscience. 2007 Apr 25;146(1):427-34. Epub 2007 Mar 7. Moreover, application of induced a sustained inward current from isolated cones, which increased in amplitude in a dose-dependent manner, with an EC50 (concentration of producing half-maximal response) of 67.3+/-4.9 microM, and the current was blocked by the glycine receptor antagonist strychnine, but not 5,7-dichlorokynurenic acid (DCKA) of 200 microM, a blocker of the recognition site at the (NMDA) receptor. |
0(0,0,0,0) | Details |
| 7916452 | Minami T, Uda R, Horiguchi S, Ito S, Hyodo M, Hayaishi O: Allodynia evoked by intrathecal administration of to conscious mice. Pain. 1994 May;57(2):217-23. Intrathecally administered strychnine and the GABAA antagonist bicuculline also induced allodynia in conscious mice. |
0(0,0,0,0) | Details |
| 12431848 | Papp M, Gruca P, Willner P: Selective blockade of drug-induced place preference conditioning by ACPC, a functional NDMA-receptor antagonist. Neuropsychopharmacology. 2002 Nov;27(5):727-43. ACPC (1-aminocyclopropanecarboxylic acid) is a partial agonist at the strychnine-insensitive glycine receptor site on the NMDA receptor complex, and a functional antagonist. |
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| 8018849 | Lambert DM, Poupaert JH, Maloteaux JM, Dumont P: Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration. Neuroreport. 1994 Mar 21;5(7):777-80. The lack of Z- affinity for the strychnine sensitive glycine receptor and the strychnine insensitive glycine receptor associated with the NMDA receptor may indicate that Z- acts either via a prodrug mechanism or per se via an alternative mechanism. |
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| 8899663 | Rodriguez-Ithurralde D, Olivera S, La Paz A, Vincent O, Rondeau A: effects on glutamate-receptor elicited acetylcholinesterase release from slices and synaptosomes of the spinal ventral horn. J Neurol Sci. 1996 Aug;139 Suppl:76-82. GLY potentiated the GEAR response in the presence of strychnine, suggesting (NMDA) receptor involvement, and was also able to evoke a strychnine-sensitive AChE release in the absence of exogenous GLU. |
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| 9084588 | Kremer E, Lev-Tov A: Localization of the spinal network associated with generation of hindlimb locomotion in the neonatal rat and organization of its transverse coupling system. J Neurophysiol. 1997 Mar;77(3):1155-70. A strychnine-resistant left-right alternating rhythm was found in the presence of and in preparations that were treated with the non-NMDA receptor blocker 6-cyano-7-nitroquinoxaline (CNQX) before and during the application of strychnine. |
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| 10634865 | Ali DW, Buss RR, Drapeau P: Properties of miniature glutamatergic EPSCs in neurons of the locomotor regions of the developing zebrafish. J Neurophysiol. 2000 Jan;83(1):181-91. In the presence of tetrodotoxin (TTX) and blockers of inhibitory receptors (strychnine and picrotoxin), we detected fast glutamatergic mEPSCs that were blocked by the AMPA/kainate receptor-selective antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). At positive voltages or in the absence of Mg (2+), a second, slower component of the mEPSCs was revealed that the (NMDA) receptor-selective antagonist DL-2-amino-5-phosphonovalerate (AP-5) abolished. |
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| 11054688 | Panigrahy A, Rosenberg PA, Assmann S, Foley EC, Kinney HC: Differential expression of glutamate receptor subtypes in human brainstem sites involved in perinatal hypoxia-ischemia. J Comp Neurol. 2000 Nov 13;427(2):196-208. This study delineates the development of and non-NMDA receptor binding in the human brainstem, particularly as it relates to issues of the trophic effects of the -mediated ventilatory response to hypoxia, and regional excitotoxic vulnerability to perinatal hypoxia-ischemia. |
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| 16376148 | Lechner SM: -based therapeutic approaches: inhibitors of transport. . Curr Opin Pharmacol. 2006 Feb;6(1):75-81. Epub 2005 Dec 22. A growing body of evidence suggests that activation of the glutamatergic system, particularly (NMDA) receptor function, may be a viable approach to the treatment of schizophrenia, and potentially other cognitive disorders. In addition, recent electrophysiological findings and data from transgenic mouse models suggest that GlyT1 might also play a role in terminating the actions of at strychnine-sensitive glycine receptors, and therefore GlyT1 antagonists also have potential for the treatment of conditions where activation of inhibitory pathways in the central nervous system might be beneficial. |
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| 8880856 | Sherman SE, Loomis CW: Strychnine-sensitive modulation is selective for non-noxious somatosensory input in the spinal cord of the rat. Pain. 1996 Aug;66(2-3):321-30. The present study investigated: (1) the pharmacology of afferent neural inputs involved in STR-dependent allodynia using neonatal and the non-NMDA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo [f] quinoxaline (NBQX); and (2) the effect of i.t. |
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| 9861038 | Bergeron R, Meyer TM, Coyle JT, Greene RW: Modulation of N-methyl-D-aspartate receptor function by transport. . Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15730-4. The effect was blocked by 2-amino-5-phosphonovaleric acid and 7-chloro- but not by strychnine. |
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| 9065844 | Rioult-Pedotti MS: Intrinsic -induced oscillations in motoneurons of an adult vertebrate spinal cord are masked by inhibition. J Neurophysiol. 1997 Feb;77(2):717-30. Oscillations required the presence of physiological Mg2+ and preincubation with strychnine, whereas incubation with bicuculline or phaclofen was not effective. Generation and maintenance of membrane potential oscillations required specific NMDA receptor activation. |
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| 8867247 | Nagy I, Woolf CJ: Lignocaine selectively reduces C fibre-evoked neuronal activity in rat spinal cord in vitro by decreasing and neurokinin receptor-mediated post-synaptic depolarizations; implications for the development of novel centrally acting analgesics. Pain. 1996 Jan;64(1):59-70. The VRP consisted of 3 distinct parts: the early, slow and prolonged components, as previously described (Thompson et al. 1992), where the early represents A beta fibre-evoked mono- and polysynaptic responses lasting for tens of milliseconds, the slow is a largely (NMDA) receptor-mediated small-calibre afferent-generated component, lasting for about 1.5 sec, and the prolonged is a neurokinin receptor-mediated long-lasting component generated by high-threshold fibres. Application of the opiate, GABAA and GABAB receptor antagonists, naloxone (1 microM), strychnine (100 microM), bicuculline (100 microM) and phaclofen (100 microM) did not alter the depressant effects of lignocaine on the VRP. |
1(0,0,0,1) | Details |
| 18255245 | Yin S, Chen Z, Yu D, Feng Y, Wang J: Local inhibition shapes duration tuning in the inferior colliculus of guinea pigs. Hear Res. 2008 Mar;237(1-2):32-48. Epub 2007 Dec 28. In the inferior colliculus (IC) of these mammals, it is recognized that the excitatory responses to sounds are mediated through AMPA and NMDA receptors while the inhibitory input is mediated through and glycine receptors. It was found that the application of bicuculline (BIC, a A blocker) and/or strychnine (STRY, a blocker) eliminated or reduced duration tuning in most units that were duration tuned (32 out of 39 for BIC, 50 out of 64 for STRY, respectively). |
1(0,0,0,1) | Details |
| 7860652 | Warner DS, Martin H, Ludwig P, McAllister A, Keana JF, Weber E: In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor site antagonists. J Cereb Blood Flow Metab. 1995 Mar;15(2):188-96. We conclude that pharmacologic antagonism of at the strychnine-insensitive glycine receptor presents a neuroprotective profile similar to that previously observed for antagonists of at the complex with a potential for fewer side effects. |
1(0,0,0,1) | Details |
| 20173309 | Nishikawa Y, Sasaki A, Kuraishi Y: Blockade of transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain. J Pharmacol Sci. 2010 Mar 19;112(3):352-60. Epub 2010 Feb 20. The lack of efficacy of GlyT1 inhibitor may be explained by activation of NMDA receptors and the down-regulation of GlyT1 in the lumbar dorsal horn. Intrathecal ALX1393 suppressed dynamic allodynia induced by intrathecal strychnine and |
1(0,0,0,1) | Details |
| 10064836 | Gao F, Wu SM: Multiple types of spontaneous excitatory synaptic currents in salamander retinal ganglion cells. Brain Res. 1999 Mar 13;821(2):487-502. Physiol. 486 (1995) 207-221] [which are equivalent to our fast AMPA receptor-mediated sEPSCs (fAMPAsEPSCs)], we found another type of AMPA receptor-mediated sEPSC with slower rise and decay time courses and larger peak amplitudes (sAMPAsEPSCs), and the NMDA receptor-mediated sEPSCs (NMDAsEPSCs) in ON-OFF ganglion cells. Spontaneous and light-evoked excitatory postsynaptic currents (sEPSCs and leEPSCs) in retinal ganglion cells of the larval tiger salamander were recorded under voltage clamp conditions from living retinal slices. sEPSCs were isolated from the spontaneous inhibitory postsynaptic currents (sIPSCs) by application of 100 M picrotoxin+1 microM strychnine. |
1(0,0,0,1) | Details |
| 16469191 | Yu D, Eldred WD: Gycine and interact to regulate the / signaling pathway in the turtle retina. Vis Neurosci. 2005 Nov-Dec;22(6):825-38. Our data show that blocking glycine receptors (GLYR) with strychnine (STRY) produced moderate increases in -like immunoreactivity -LI) in select types of amacrine and bipolar cells, and strong increases in NO-induced fluorescence (NO-IF). |
0(0,0,0,0) | Details |
| 7892422 | McAllister KH: D-cycloserine enhances social behaviour in individually-housed mice in the resident-intruder test. Psychopharmacology. 1994 Nov;116(3):317-25. The increases in social investigation induced by DCS (320.0 mg/kg) in resident mice were not reversible with R-HA 966 (32.0 mg/kg IP, 30 min before testing), a blocker of the strychnine-insensitive modulatory site associated with the N-methyl-D-aspartate receptor, but were blocked by the antagonist bicuculline (0.56 mg/kg IP, 5 min before testing). |
0(0,0,0,0) | Details |
| 7862877 | Matheus MG, Nogueira RL, Carobrez AP, Graeff FG, Guimaraes FS: Anxiolytic effect of antagonists microinjected into the dorsal periaqueductal grey. Psychopharmacology. 1994 Jan;113(3-4):565-9. To investigate if blockade of the modulatory site of NMDA receptors in the dorsal periaqueductal grey (DPAG) would produce anxiolytic effects, groups of 9-14 rats received microinjections into this structure of 7-chloro- (7-Cl-KY, 4 and 8 nmol) or 3-amino-1-hydroxypyrrolid-2-one (HA-966, 30 or 100 nmol), two selective antagonists at the strychnine-insensitive modulatory site, and were submitted to the elevated plus-maze, an ethologically based animal model of anxiety. |
31(0,1,1,1) | Details |
| 9518553 | McGaraughty S, Henry JL: The effects of strychnine, bicuculline, and ketamine on 'immersion-inhibited' dorsal horn convergent neurons in intact and spinalized rats. Brain Res. 1998 Feb 16;784(1-2):63-70. In both intact and spinalized rats, this study examined the effects of strychnine (a antagonist), bicuculline (a GABAA antagonist), and ketamine (a non-competitive NMDA receptor antagonist) on one particular class of lumbar dorsal horn convergent neurons. |
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| 19782664 | Yin H, Lee KE, Park SA, Bhattarai JP, Suh BJ, Jeon JG, Kim BG, Park SJ, Han SK: Inhibitory effects of somatostatin on the substantia gelatinosa neurons of trigeminal subnucleus caudalis via somatostatin type 2 receptors in juvenile mice. Brain Res. 2009 Dec 22;1304:49-56. Epub 2009 Sep 24. The SST-induced hyperpolarizing response was maintained in the presence of TTX (Na (+) channel blocker), AP-5 (NMDA receptor antagonist), CNQX (non- glutamate receptor antagonist), picrotoxin (A) receptor antagonist) and strychnine (glycine receptor antagonist), respectively, suggesting that SST has direct effects on the postsynaptic SG neurons. |
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| 8968129 | Cano G, Suarez-Roca H, Bonilla E: poisoning reduces strychnine-insensitive binding sites in the globus pallidus of the mouse brain. Invest Clin. 1996 Dec;37(4):209-19. Due to the close relationship between sites and strychnine-insensitive (Gly) modulatory sites in the NMDA receptor complex, the [3H]- ([3H]-Gly) binding was analyzed by autoradiographic methods in the brain of mice treated with for 8 weeks. |
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| 19776366 | Palazzo E, Guida F, Migliozzi A, Gatta L, Marabese I, Luongo L, Rossi C, de Novellis V, Fernandez-Sanchez E, Soukupova M, Zafra F, Maione S: Intraperiaqueductal gray and exert dual effects on rostral ventromedial medulla ON- and OFF-cell activity and thermoceptive threshold in the rat. J Neurophysiol. 2009 Dec;102(6):3169-79. Epub 2009 Sep 23. We have studied the involvement of the N-methyl-D-aspartate receptor (NMDAR) site and the strychnine-sensitive glycine receptor (GlyR) in the ventrolateral periaqueductal gray (VL-PAG) on nociceptive behavior (tail flick) and pain-related changes on neuronal activity in the rostral ventromedial medulla (RVM). |
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| 7807141 | Rodriguez-Ithurralde D, Vincent O: Excitotoxicity and cholinergic chemical markers during programmed motor neurone death. J Neurol Sci. 1994 Jul;124 Suppl:52-3. Strychnine-resistant stimulation potentiated -induced AChE release, suggesting (NMDA) receptor involvement. |
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| 11731558 | Keefer EW, Gramowski A, Gross GW: NMDA receptor-dependent periodic oscillations in cultured spinal cord networks. J Neurophysiol. 2001 Dec;86(6):3030-42. During disinhibition with bicuculline and strychnine, synchronized burst patterns routinely emerge. |
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| 8098757 | Tamura Y, Sato Y, Yokota T, Akaike A, Sasa M, Takaori S: Ifenprodil prevents cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons. J Pharmacol Exp Ther. 1993 May;265(2):1017-25. Either a polyamine modulatory site agonist, or a strychnine-insensitive site agonist, potentiated - and -induced cytotoxicity. |
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| 8088343 | Wlaz P, Baran H, Loscher W: Effect of the /NMDA receptor partial agonist, D-cycloserine, on seizure threshold and some pharmacodynamic effects of MK-801 in mice. Eur J Pharmacol. 1994 May 23;257(3):217-25. Acute treatment of mice with D-cycloserine (a high efficacy, partial agonist at strychnine-insensitive glycine receptors) resulted in dose- and time-dependent increases in the threshold for electrically induced tonic seizures. |
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| 12663257 | Chen Z, Travers JB: Inactivation of amino acid receptors in medullary reticular formation modulates and suppresses ingestion and rejection responses in the awake rat. Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R68-83. Epub 2003 Mar 27. Bilateral infusions of the (A) receptor antagonist bicuculline or the glycine receptor antagonist strychnine enhanced the amplitude of IO stimulation-induced oral responses. Bilateral microinjection of the (NMDA) receptor antagonist d-[(3)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (D-CPP) suppressed licking and gape responses recorded electromyographically from a subset of orolingual muscles. |
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