| 8953423 |
Bum EN, Meier CL, Urwyler S, Wang Y, Herrling PL: Extracts from rhizomes of Cyperus articulatus (Cyperaceae) displace [3H] CGP39653 and [3H] glycine binding from cortical membranes and selectively inhibit NMDA receptor-mediated neurotransmission. J Ethnopharmacol. 1996 Nov;54(2-3):103-11.
The marshland plant Cyperus articulatus (Cyperaceae) is commonly used in traditional medicine in Africa and Latin America to treat a wide variety of human diseases ranging from headache to epilepsy. We tested the hypothesis that the purported anti-epileptic effect of this plant might be due to a functional inhibition of excitatory amino acid receptors. One or several component (s) contained in the extracts inhibited the binding of [3H] CGP39653 to the NMDA recognition site and of [3H] glycine to the strychnine-insensitive glycine site of the NMDA receptor complex from rat neocortex. Water extracts from rhizomes of Cyperus articulatus dose-dependently reduced spontaneous epileptiform discharges and NMDA-induced depolarizations in the rat cortical wedge preparation at concentrations at which AMPA-induced depolarizations were not affected. We conclude that the purported beneficial effects of Cyperus articulatus might at least partially be due to inhibition of NMDA-mediated neurotransmission. |
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