| 10091723 |
Nowak G, Ossowska G, Jopek R, Papp M: Strychnine-insensitive glycine/NMDA sites are altered in two stress models of depression. Pol J Pharmacol. 1998 Jul-Oct;50(4-5):365-9.
Chronic severe stress (CSS) and chronic mild stress (CMS) affect the properties of [3H] 5,7-dichlorokynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine/NMDA sites in the rat cerebral cortex. Specifically, CSS decreases, while CMS increases, the potency of glycine to displace [3H] 5,7-DCKA binding to glycine/NMDA sites. Moreover, in both models, a reduction of the specific [3H] 5,7-DCKA binding was observed. The present results demonstrate the involvement of the cortical NMDA receptor complex in the animal models of depression. |
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