Protein Information

Name GABA transporter
Synonyms GABA transporter; GABATHG; GABATR; GABT 1; GABT1; GAT 1; GAT1; Gamma aminobutyric acid transporter…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
7823028 Jursky F, Tamura S, Tamura A, Mandiyan S, Nelson H, Nelson N: Structure, function and brain localization of neurotransmitter transporters. J Exp Biol. 1994 Nov;196:283-95.

A correlation as observed between the pattern we obtained and that observed previously from strychnine binding studies.
For example, the GABA transporter GAT4, which also transports beta-alanine, was localized to neurons.
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15885796 Raiteri L, Zappettini S, Stigliani S, Paluzzi S, Raiteri M, Bonanno G: Glutamate release induced by activation of glycine and GABA transporters in spinal cord is enhanced in a mouse model of amyotrophic lateral sclerosis. Neurotoxicology. 2005 Oct;26(5):883-92.


Potentiation of the spontaneous amino acid release is likely to be mediated by activation of a GLY or a GABA transporter, since the effect of GLY was counteracted by the GLY transporter blocker glycyldodecylamide but not by the GLY receptor antagonists strychnine and 5,7-dichlorokynurenate while the effect of GABA was diminished by the GABA transporter blocker SKF89976-A but not by the GABA receptor antagonists SR9531 and CGP52432.
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