| Name | taste receptors (protein family or complex) |
|---|---|
| Synonyms | taste receptor; taste receptors |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11328963 | Inoue M, Li X, McCaughey SA, Beauchamp GK, Bachmanov AA: Soa genotype selectively affects mouse gustatory neural responses to octaacetate. Physiol Genomics. 2001 Apr 27;5(4):181-6. The SWR/J and SW.B6-Soa (b) mice did not differ in responses of either nerve to NaCl, HCl, or the bitter-tasting stimuli quinine, denatonium, strychnine, 6-n-propylthiouracil, phenylthiocarbamide, and MgSO (4). Thus the effect of the Soa genotype on SOA avoidance is mediated by peripheral taste responsiveness to SOA, involving taste receptor cells innervated by both the CT and GL nerves. |
1(0,0,0,1) | Details |
| 9187310 | Dahl M, Erickson RP, Simon SA: Neural responses to bitter compounds in rats. Brain Res. 1997 May 9;756(1-2):22-34. To determine whether the idiosyncratic distribution of transduction mechanisms for bitter tastants in rat taste receptor cells (TRCs) could be inferred from the neural activity they evoke, single neuron responses to ten bitter-tasting compounds were recorded from rat glossopharyngeal (n = 30) and chorda tympani (n = 22) neurons. Responses to several 'bitter' alkaloids were obtained: 10 mM quinine-HCl, 50 mM and 1 mM each yohimbine, and strychnine, plus a number of non-alkaloid bitter-tasting compounds: 0.1 M KCl, 0.01 M MgCl2, and 1 mM each phenylthiocarbamide (PTC), and denatonium |
1(0,0,0,1) | Details |
| 15389687 | Hiroi M, Meunier N, Marion-Poll F, Tanimura T: Two antagonistic gustatory receptor neurons responding to sweet-salty and bitter taste in Drosophila. J Neurobiol. 2004 Dec;61(3):333-42. These sensilla thus house two GRNs having an antagonistic effect on behavior, suggesting that the expression of taste receptors is segregated across them accordingly. The second GRN detects a range of bitter compounds, among which strychnine is the most potent; and also to salt at high concentrations (over 400 mM NaCl). |
1(0,0,0,1) | Details |
| 7878081 | Kurihara K, Katsuragi Y, Matsuoka I, Kashiwayanagi M, Kumazawa T, Shoji T: Receptor mechanisms of bitter substances. Physiol Behav. 1994 Dec;56(6):1125-32. The receptor mechanism of bitter substances was discussed from the following points of views. (a) Both electrostatic and hydrophobic interactions of bitter substances with taste receptor membranes contribute to reception of bitter substances having a positive charge. (b) In the frog, the responses to bitter substances are easily adapted. |
1(0,0,0,1) | Details |
| 17595105 | Brockhoff A, Behrens M, Massarotti A, Appendino G, Meyerhof W: Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. J Agric Food Chem. 2007 Jul 25;55(15):6236-43. Epub 2007 Jun 27. |
8(0,0,1,3) | Details |
| 9671782 | Ming D, Ruiz-Avila L, Margolskee RF: Characterization and solubilization of bitter-responsive receptors that couple to gustducin. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8933-8. Rod transducin, which is also expressed in taste receptor cells, can be activated by the bitter compound denatonium in the presence of bovine taste membranes. In this paper, we show that gustducin is expressed in bovine taste tissue and that both gustducin and transducin, in the presence of bovine taste membranes, can be activated specifically by several bitter compounds, including denatonium, quinine, and strychnine. |
3(0,0,0,3) | Details |
| 17253962 | Sainz E, Cavenagh MM, Gutierrez J, Battey JF, Northup JK, Sullivan SL: Functional characterization of human bitter taste receptors. . Biochem J. 2007 May 1;403(3):537-43. We also demonstrate that hT2R14 is a receptor for aristolochic acid and report the first characterization of the ligand specificities of hT2R7, which is a broadly tuned receptor responding to strychnine, quinacrine, chloroquine and papaverine. |
1(0,0,0,1) | Details |
| 16107527 | Lemon CH, Smith DV: Neural representation of bitter taste in the nucleus of the solitary tract. J Neurophysiol. 2005 Dec;94(6):3719-29. Epub 2005 Aug 17. Based on the molecular findings that many bitter taste receptors (T2Rs) are expressed within the same receptor cells, it has been proposed that bitter taste is encoded by the activation of discrete neural elements. Taste responses (spikes/s) evoked by bathing the tongue and palate with intensity-matched concentrations (in M) of 2 sugars (0.32 and 0.5 (40%), 4 salts (0.01 NaCl, 0.008 NaNO (3), 0.01 MgCl (2), and 0.05 KCl), 2 acids (0.003 HCl and 0.005 and 10 bitter ligands (0.007 quinine-HCl, 0.015 denatonium 0.003 0.001 0.005 strychnine-HCl, 0.04 tetraethylammonium 0.03 atropine-SO (4), 0.005 brucine-SO (4), 0.03 papaverine-HCl, and 0.009 sparteine) were recorded from 51 neurons in the nucleus of the solitary tract of anesthetized rats. |
1(0,0,0,1) | Details |
| 10449792 | Ming D, Ninomiya Y, Margolskee RF: Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9903-8. We have monitored this activation with an in vitro assay to identify compounds that inhibited taste receptor activation of transducin by bitter tastants: AMP and chemically related compounds inhibited in vitro responses to several bitter compounds (e.g., denatonium, quinine, strychnine, and atropine). |
34(0,1,1,4) | Details |
| 11245589 | Yan W, Sunavala G, Rosenzweig S, Dasso M, Brand JG, Spielman AI: Bitter taste transduced by PLC-beta (2)-dependent rise in IP (3) and alpha-gustducin-dependent fall in cyclic nucleotides. Am J Physiol Cell Physiol. 2001 Apr;280(4):C742-51. Using quench-flow techniques, we show here that the bitter stimuli, denatonium and strychnine, induce rapid (50-100 ms) and transient reductions in cAMP and and increases in IP (3) in murine taste tissue. These data suggest a transduction mechanism for bitter taste involving the rapid and transient metabolism of dual second messenger systems, both mediated through a taste cell G protein, likely composed of Galpha (gust)/beta/gamma (13), with both systems being simultaneously activated in the same bitter-sensitive taste receptor cell. |
1(0,0,0,1) | Details |
| 12775144 | Kim JH, Mullin CA: Antifeedant effects of proteinase inhibitors on feeding behaviors of adult western corn rootworm (Diabrotica virgifera virgifera). J Chem Ecol. 2003 Apr;29(4):795-810. Leupeptin was the strongest (ED50 = 0.36 and 0.55 nmol/disk for Cuc B and CPE, respectively) among PIs tested with an antifeedant potency much stronger than the steroid (ED50 = 2.29 and 5.05 nmol/disk for Cuc B and CPE, respectively), but slightly less than the reference alkaloid, strychnine (ED50 = 0.17 and 0.37 nmol/disk for Cuc B and CPE, respectively). All active PIs contain a di- or tripeptidyl moiety, indicating that PIs exert their antifeedant effects by covalent interaction with putative sulfhydryl (SH) groups on taste receptors as do these PIs with proteinases. |
1(0,0,0,1) | Details |
| 9589160 | Liu L, Simon SA: Responses of cultured rat trigeminal ganglion neurons to bitter tastants. Chem Senses. 1998 Apr;23(2):125-30. The initial steps in taste and olfaction result from the activation by chemical stimuli of taste receptor cells (TRCs) and olfactory receptor neurons (ORNs). In a recent single unit study we investigated the responses of rat chorda tympani and glossopharnygeal neurons to a variety of bitter-tasting alkaloids, including yohimbine, quinine, strychnine and as well as the pungent ingredient in hot pepper. |
1(0,0,0,1) | Details |