| Name | CA1 |
|---|---|
| Synonyms | CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14568560 | Kondratskaya EL, Pankratov YV, Lalo UV, Chatterjee SS, Krishtal OA: Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. Neurochem Int. 2004 Feb;44(3):171-7. The effect of ginkgolide B on LTP did not alter considerably if GlyRs were blocked by strychnine (2 microM). The question is as follows: is the alteration of LTP by BN52021 due to the PAF antagonism or to the inhibition of -gated channels? We have studied the effects of ginkgolides B and J on LTP induced in the CA1 area of rat hippocampus. |
1(0,0,0,1) | Details |
| 12505654 | Yu K, Ge SY, Ruan DY: Fe2+ decreases the -induced Cl- current in acutely dissociated rat hippocampal neurons. Brain Res. 2003 Jan 17;960(1-2):25-35. The effects of ferrous ions (Fe (2+)) on -induced Cl (-) current (I (tau)) recorded from single neurons, which was freshly isolated from the rat hippocampal CA1 area, were studied with conventional whole-cell recording under voltage-clamp conditions. Using standard pharmacological approaches, we found that the currents gated by concentrations of ( |
1(0,0,0,1) | Details |
| 9548821 | Maryanoff BE, Costanzo MJ, Nortey SO, Greco MN, Shank RP, Schupsky JJ, Ortegon MP, Vaught JL: Structure-activity studies on anticonvulsant sugar sulfamates related to J Med Chem. 1998 Apr 9;41(8):1315-43. Cyclic 2, like and phenytoin, did not interfere with seizures induced by pentylenetetrazole, bicucculine, picrotoxin, and strychnine; also, 2 was not active in diverse in vitro receptor binding and uptake assays. However, 2 turned out to be a potent inhibitor of carbonic anhydrase from different rat tissue sources (e. g., IC50 of 84 nM for the blood enzyme and 21 nM for the brain enzyme). |
1(0,0,0,1) | Details |
| 14530208 | Rouaud E, Billard JM: D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices. Br J Pharmacol. 2003 Nov;140(6):1051-6. Epub 2003 Oct 6. In the present study, we have investigated the effects of DCS on glutamatergic neurotransmission and synaptic plasticity in CA1 region of rat hippocampal slices, using extracellular field excitatory postsynaptic potentials. 2. This inhibition was not prevented by the GABAA antagonist bicuculline, but was antagonized by the antagonist strychnine. 4. |
1(0,0,0,1) | Details |
| 9439847 | Wu J, Jin GZ: Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus. Brain Res. 1997 Nov 14;775(1-2):214-8. In the patch-clamp perforated whole-cell recording mode, tetrahydroberberine (THB), a novel (DA) receptor antagonist, inhibits not only DA-induced outward K+ currents, but also -, - or strychnine-induced outward current. |
1(0,0,0,1) | Details |
| 12429224 | Wu HQ, Lee SC, Scharfman HE, Schwarcz R: L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat. Exp Neurol. 2002 Sep;177(1):222-32. Blockade of the strychnine-insensitive site of the NMDA receptor is considered an attractive strategy for the development of novel neuroprotective and anticonvulsive agents. 7-Cl- (7-Cl-KYNA) is a potent, selective antagonist of the /glycine receptor but penetrates poorly through the blood-brain barrier. Repeated 4-Cl-KYN administration also prevented KA-induced lesions in the piriform cortex and provided protection of hippocampal pyramidal cells in area CA1. |
1(0,0,0,1) | Details |
| 11877523 | Chattipakorn SC, McMahon LL: Pharmacological characterization of -gated currents recorded in rat hippocampal slices. J Neurophysiol. 2002 Mar;87(3):1515-25. An inhibitory role for strychnine-sensitive -gated channels (GlyRs) in mature hippocampus has been overlooked, largely due to the misconception that GlyR expression ceases early during development and to few functional studies demonstrating their presence. In this study, we used pharmacological tools and whole cell patch-clamp recordings of CA1 pyramidal cells and interneurons in acutely prepared hippocampal slices from 3- to 4-wk old rats to characterize these understudied receptors. |
1(0,0,0,1) | Details |
| 7477740 | Fossom LH, Von Lubitz DK, Lin RC, Skolnick P: Neuroprotective actions of 1-aminocyclopropanecarboxylic acid (ACPC): a partial agonist at strychnine-insensitive sites. Neurol Res. 1995 Aug;17(4):265-9. Survival of hippocampal CA1 neurons (quantitated 7 days post-ischemia) was significantly (approximately 3-fold) increased by the 600 mg kg-1 dose. |
1(0,0,0,1) | Details |
| 7529821 | Amato A, Ballerini L, Attwell D: Intracellular pH changes produced by uptake in rat hippocampal slices. J Neurophysiol. 1994 Oct;72(4):1686-96. The mean intracellular pH in area CA1 of rat hippocampal slices was monitored fluorescently after loading the cells with the dye BCECF-AM. 2. The -evoked acidification was not significantly reduced by blockers of -gated ion channels [6-cyano-7-nitroquinoxaline-2,3- dione (CNQX) and D-aminophosphonovalerate (APV)] nor by blockers of - and -gated channels (picrotoxin and strychnine), and so was not produced by H+ entry through alpha-amino-3--5-methyl-4- isoxazolepropionic acid (AMPA) or (NMDA) receptor channels nor by HCO3- exit through the channels controlled by or 4. |
1(0,0,0,1) | Details |
| 7860652 | Warner DS, Martin H, Ludwig P, McAllister A, Keana JF, Weber E: In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor site antagonists. J Cereb Blood Flow Metab. 1995 Mar;15(2):188-96. We conclude that pharmacologic antagonism of at the strychnine-insensitive glycine receptor presents a neuroprotective profile similar to that previously observed for antagonists of at the complex with a potential for fewer side effects. |
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| 7912632 | Shuker MA, Bowser-Riley F, Davies SN: Possible antagonist properties of drugs that affect high pressure neurological syndrome. Br J Pharmacol. 1994 Mar;111(3):951-5. Previous studies have suggested that a series of drugs modelled on part of the strychnine molecule interfere with the development of high pressure neurological syndrome (HPNS) and it was presumed that this effect was via an action on inhibitory glycinergic transmission. |
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| 9786501 | Platt B, Bate JR, von Linstow Roloff E, Withington DJ: induces a novel form of long-term potentiation in the superficial layers of the superior colliculus. Br J Pharmacol. 1998 Sep;125(2):293-300. LTPgly could only be masked but not prevented by strychnine (100 microM) and remained undisturbed in the presence of picrotoxin (100 microM). 5. |
0(0,0,0,0) | Details |
| 19523966 | Mok MH, Fricker AC, Weil A, Kew JN: Electrophysiological characterisation of the actions of at ligand-gated ion channels. Neuropharmacology. 2009 Sep;57(3):242-9. Epub 2009 Jun 11. KynA inhibited AMPA-evoked currents to a similar degree in cultured hippocampal neurons and a human GluR2 (flip/unedited) cell line (IC (50): 433 and 596 muM, respectively) and at higher concentrations, kynA also inhibited the strychnine-sensitive glycine receptor ( approximately 35% inhibition by 3 mM kynA). |
0(0,0,0,0) | Details |
| 12612034 | Chattipakorn SC, McMahon LL: Strychnine-sensitive glycine receptors depress hyperexcitability in rat dentate gyrus. J Neurophysiol. 2003 Mar;89(3):1339-42. Epub 2002 Nov 6. We now report that application to dentate granule cells and hilar interneurons recorded in acute slices from adolescent rats elicits a strychnine-sensitive current similar to -mediated currents recorded in area CA1, indicating that GlyRs are also present on neurons in the dentate gyrus. |
87(1,1,2,2) | Details |
| 16381810 | Song W, Chattipakorn SC, McMahon LL: -gated channels depress synaptic transmission in rat hippocampus. J Neurophysiol. 2006 Apr;95(4):2366-79. Epub 2005 Dec 28. Using whole cell current-clamp recordings, we show that activation of strychnine-sensitive GlyRs through exogenous application causes a significant decrease in input resistance and prevents somatically generated action potentials in both CA1 pyramidal cells and interneurons. |
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| 18632940 | Keck T, Lillis KP, Zhou YD, White JA: Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus. J Neurosci. 2008 Jul 16;28(29):7359-69. We find that strychnine-sensitive GlyRs are open in the resting CA1 pyramidal cell, creating a state of tonic inhibition that "shunts" the magnitude of EPSPs evoked by electrical stimulation of the Schaffer collateral inputs. |
32(0,1,1,2) | Details |
| 17913992 | Zhang HX, Thio LL: enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons. J Neurophysiol. 2007 Dec;98(6):3666-76. Epub 2007 Oct 3. To test this possibility, we examined the effect of the GlyR antagonist strychnine and the Zn (2+) chelator tricine on action potential firing by CA1 pyramidal neurons in mouse hippocampal slices. |
31(0,1,1,1) | Details |
| 16107637 | Lozovaya N, Yatsenko N, Beketov A, Tsintsadze T, Burnashev N: Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids. J Neurosci. 2005 Aug 17;25(33):7499-506. We also demonstrate that, in the presence of a (A) receptor antagonist, GlyRs may contribute to the generation of seizure-like activity induced by short bursts (seven stimuli) of high-frequency stimulation of inputs to hippocampal CA1 region, because this activity was diminished by selective GlyR antagonists (strychnine and ginkgolides B and J). |
31(0,1,1,1) | Details |
| 7796152 | Newell DW, Barth A, Malouf AT: site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures. Brain Res. 1995 Mar 27;675(1-2):38-44. Ischemia-induced neuronal injury can be reduced by antagonists acting at the (NMDA) receptor. 7-Chlorokynurenic acid and the recently synthesized compound Acea 1021 block NMDA receptors by acting at the strychnine-insensitive site. The anti-ischemic properties of these compounds were tested by evaluating their ability to reduce CA1 neuronal damage in hippocampal slice cultures deprived of and |
3(0,0,0,3) | Details |
| 9223540 | Yuan Y, Atchison WD: Action of methylmercury on (A) receptor-mediated inhibitory synaptic transmission is primarily responsible for its early stimulatory effects on hippocampal CA1 excitatory synaptic transmission. J Pharmacol Exp Ther. 1997 Jul;282(1):64-73. Pretreatment of slices with strychnine, did not prevent MeHg-induced early increase in population spikes. |
4(0,0,0,4) | Details |
| 10958157 | Pozza MF, Zimmerman K, Bischoff S, Lingenhohl K: Electrophysiological characterization of CGP68730A a N-methyl-D- antagonist acting at the strychnine-insensitive site. Prog Neuropsychopharmacol Biol Psychiatry. 2000 May;24(4):647-70. Extracellular recordings were done in vitro in the neocortical slice and in the CA1 region of the hippocampal slice and in vivo in the CA1 region of the hippocampus of the anaesthetized rat. 2. |
2(0,0,0,2) | Details |
| 8922750 | Wu J, Harata N, Akaike N: Potentiation by sevoflurane of the -induced current in acutely dissociated CA1 pyramidal neurones from rat hippocampus. Br J Pharmacol. 1996 Nov;119(5):1013-21. But ISev was insensitive to strychnine (Str), an antagonist of the glycine receptor. 4. |
2(0,0,0,2) | Details |
| 9707286 | Lingenhohl K, Pozza MF: Reevaluation of ACEA 1021 as an antagonist at the strychnine-insensitive site of the N-methyl-D-aspartate receptor. Neuropharmacology. 1998 Jun;37(6):729-37. In vivo, ACEA 1021 was tested on -induced excitation in the CA1 region. |
2(0,0,0,2) | Details |
| 11893914 | Li Y, Xu TL: State-dependent cross-inhibition between anionic (A) and ionotropic receptors in rat hippocampal CA1 neurons. Neuroreport. 2002 Feb 11;13(2):223-6. The current inhibition was also absent in the presence of Gly or (A) receptor antagonists, strychnine or bicuculline, respectively. |
2(0,0,0,2) | Details |
| 15140905 | Bieda MC, MacIver MB: Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability. J Neurophysiol. 2004 Sep;92(3):1658-67. Epub 2004 May 12. We examined effects of propofol on the intrinsic excitability of hippocampal CA1 neurons (primarily interneurons) recorded from adult rat brain slices. Propofol-induced depression of intrinsic excitability was completely reversed by bicuculline and picrotoxin but was strychnine-insensitive, implicating (A) but not glycine receptors. |
2(0,0,0,2) | Details |
| 10022256 | Albuquerque EX, Pereira EF, Braga MF, Matsubayashi H, Alkondon M: Neuronal nicotinic receptors modulate synaptic function in the hippocampus and are sensitive to blockade by the convulsant strychnine and by the anti-Parkinson drug Toxicol Lett. 1998 Dec 28;102-103:211-8. Evidence is provided that rapid application of nicotinic agonists to CA1 interneurons in hippocampal slices can trigger responses with at least one of three components: (i) whole-cell currents due to activation of nicotinic receptors (nAChRs) on the neuron under study; (ii) fast current transients representing back-propagating action potentials; and (iii) post-synaptic currents mediated by released from presynaptic neurons by activation of preterminal nAChRs. |
1(0,0,0,1) | Details |
| 11069593 | Zaninetti M, Raggenbass M: Oxytocin receptor agonists enhance inhibitory synaptic transmission in the rat hippocampus by activating interneurons in stratum pyramidale. Eur J Neurosci. 2000 Nov;12(11):3975-84. binding sites are present in the subiculum and CA1 region and can excite a class of CA1 nonpyramidal neurons. These peptide-enhanced IPSCs were blocked by bicuculline, but not by strychnine, and reversed near 0 mV, indicating that they were mediated by A receptors. |
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| 9622238 | Kira T, Harata N, Sakata T, Akaike N: Kinetics of sevoflurane action on - and -induced currents in acutely dissociated rat hippocampal neurons. Neuroscience. 1998 Jul;85(2):383-94. Effects of a new kind of volatile anaesthetics, sevoflurane, on - and -gated current (ICl) were examined in single pyramidal neurons acutely dissociated from the rat hippocampal CA1 region, using the voltage-clamp mode of the nystatin-perforated patch-clamp technique. Pretreatment with 3 x 10 (-8) M strychnine markedly prolonged the time to peak of the -induced ICl. |
1(0,0,0,1) | Details |
| 11850512 | Mori M, Gahwiler BH, Gerber U: and as endogenous agonists at glycine receptors in rat hippocampus in vitro. J Physiol. 2002 Feb 15;539(Pt 1):191-200. In the presence of ionotropic and GABA (B) receptor antagonists, pressure-application of onto CA3 pyramidal cells induced a current associated with increased conductance, which was inhibited by strychnine. Whole-cell responses were significantly greater in CA3 pyramidal cells than in CA1 pyramidal cells and dentate granule cells, while responses to were similar among these three cell types. |
1(0,0,0,1) | Details |
| 8558460 | Shimizu-Sasamata M, Kawasaki-Yatsugi S, Okada M, Sakamoto S, Yatsugi S, Togami J, Hatanaka K, Ohmori J, Koshiya K, Usuda S, Murase K: YM90K: pharmacological characterization as a selective and potent alpha-amino-3--5-methylisoxazole-4-/kainate receptor antagonist. J Pharmacol Exp Ther. 1996 Jan;276(1):84-92. YM90K selectively displaced [3H]-AMPA binding (Ki = 0.084 microM) and was less potent in inhibiting [3H]-kainate (Ki = 2.2 microM), [3H]- -sensitive site; Ki > 100 microM) and [3H]- (strychnine-insensitive site; Ki = 37 microM) binding to rat brain membranes. In a global ischemia model, YM90K (15 mg/kg i.p. x 3), NBQX (30 mg/kg i.p. x 3) and CNQX (60 mg/kg i.p. x 3) significantly prevented the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia. |
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| 7893259 | Dimpfel W: Effects of memantine on synaptic transmission in the hippocampus in vitro. Arzneimittelforschung. 1995 Jan;45(1):1-5. CA1 pyramidal cell response (population spike) in the hippocampal slice preparation was monitored after electrical stimulation of the Schaffer collaterals at CA2 in the presence of different concentrations of memantine (1-amino-3,5-dimethyladamantane, Akatinol Memantine, CAS 41100-52-1) currently being prescribed for the treatment of e.g. dementia. The concentration dependent action of an agonist acting at the strychnine insensitive -site of the receptor was enhanced in the presence of 1 mumol/l of memantine. |
1(0,0,0,1) | Details |
| 15288514 | Peterson SL, Purvis RS, Griffith JW: Differential neuroprotective effects of the NMDA receptor-associated site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus. Neurotoxicology. 2004 Sep;25(5):835-47. The present study determined whether 1-aminocyclopropanecarboxylic acid (ACPC) or D-cycloserine (DCS), both partial agonists of the strychnine-insensitive site on the NMDA receptor ionophore complex, exerted anticonvulsant or neuroprotectant activity in Li-pilo SE. ACPC administered 5 min after SE onset produced significant neuroprotection in cortical regions, amygdala and CA1 of the hippocampus. |
1(0,0,0,1) | Details |
| 16631121 | Zhang LH, Xu L, Xu TL: Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats. Biochem Biophys Res Commun. 2006 Jun 9;344(3):721-6. Epub 2006 Apr 17. Moreover, application increased the paired-pulse ratio (PPR) of PSCs significantly, an effect largely abolished by the GlyR specific antagonist strychnine. |
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| 10082275 | Ren J, Ye JH, Liu PL, Krnjevic K, McArdle JJ: Cocaine decreases the -induced Cl- current of acutely dissociated rat hippocampal neurons. Eur J Pharmacol. 1999 Feb 12;367(1):125-30. The effects of cocaine on -induced Cl- current (I (GLY)) of single neurons, freshly isolated from the rat hippocampal CA1 area, were studied with conventional whole-cell recording under voltage-clamp conditions. The cocaine suppression of I (GLY) was unaffected by 1 microM tetrodotoxin and 1 microM strychnine. |
1(0,0,0,1) | Details |
| 9004347 | Kawasaki K, Eigyo M, Ikeda M, Kihara T, Koike K, Matsushita A, Murata S, Shiomi T, Takada S, Yasui M: A novel benzodiazepine inverse agonist, S-8510, as a cognitive enhancer. Prog Neuropsychopharmacol Biol Psychiatry. 1996 Nov;20(8):1413-25. S-8510 augmented LTP of the Schaffer collateral/commissural fiber-CA1 synapses in the hippocampal slice preparations of SD rat. 5. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. 7. |
1(0,0,0,1) | Details |
| 7957739 | Wamsley JK, Sofia RD, Faull RL, Narang N, Ary T, McCabe RT: Interaction of felbamate with [3H] DCKA-labeled strychnine-insensitive glycine receptors in human postmortem brain. Exp Neurol. 1994 Oct;129(2):244-50. In many regions, [3H] DCKA binding was reduced to background in the presence of felbamate, but some areas retained binding by as much as 41% (i.e., the CA2 region of the hippocampus). |
1(0,0,0,1) | Details |
| 9114240 | Luckermann M, Trapp S, Ballanyi K: - and -mediated fall of intracellular pH in rat medullary neurons in situ. J Neurophysiol. 1997 Apr;77(4):1844-52. These responses were abolished by 10-100 microM strychnine. Dialysis of the cells with 15-30 microM carbonic anhydrase led to an acceleration of the kinetics and a potentiation of the -induced pHi decrease. |
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| 8786846 | Jones MG, Szatkowski MS: The role of in anoxia/aglycaemia-induced potentiation of N-methyl-D-aspartate receptor-mediated postsynaptic potentials in the rat hippocampus. Neurosci Lett. 1995 Dec 15;201(3):227-30. Addition of large saturating concentrations of (100 microM and 1 mM) to the superfusate resulted in increased extracellularly recorded NMDA receptor-mediated components of excitatory postsynaptic potentials (EPSPs) recorded in area CA1. The effects of added were strychnine-insensitive and blocked by a competitive antagonist. |
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