| Name | CA3 |
|---|---|
| Synonyms | CA III; Carbonic anhydrase C; CA3; CAIII; Car3; Carbonate dehydratase III; Carbonic anhydrase 3; Carbonic anhydrase III… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11850512 | Mori M, Gahwiler BH, Gerber U: and as endogenous agonists at glycine receptors in rat hippocampus in vitro. J Physiol. 2002 Feb 15;539(Pt 1):191-200. In the presence of ionotropic and GABA (B) receptor antagonists, pressure-application of onto CA3 pyramidal cells induced a current associated with increased conductance, which was inhibited by strychnine. |
33(0,1,1,3) | Details |
| 18593588 | Park EJ, Choi IS, Cho JH, Nakamura M, Lee JJ, Lee MG, Choi BJ, Moorhouse AJ, Jang IS: modulation of glycine receptors in acutely isolated rat CA3 neurons. . Life Sci. 2008 Aug 1;83(5-6):149-54. Epub 2008 Jun 15. These pharmacological properties strongly suggest that CA3 neurons express functional strychnine-sensitive glycine receptors containing alpha2 subunits. |
9(0,0,1,4) | Details |
| 20152805 | Kubota H, Alle H, Betz H, Geiger JR: Presynaptic glycine receptors on hippocampal mossy fibers. Biochem Biophys Res Commun. 2010 Mar 19;393(4):587-91. Epub 2010 Feb 10. In MFBs, focal puff-application of -evoked currents that were blocked by the GlyR antagonist strychnine. Our results demonstrate that functional presynaptic GlyRs are present on hippocampal mossy fiber terminals and suggest a role of these receptors in the regulation of release during the development of the mossy fiber--CA3 synapse. |
1(0,0,0,1) | Details |
| 19200346 | Lee EA, Cho JH, Choi IS, Nakamura M, Park HM, Lee JJ, Lee MG, Choi BJ, Jang IS: Presynaptic glycine receptors facilitate spontaneous release onto hilar neurons in the rat hippocampus. J Neurochem. 2009 Apr;109(1):275-86. Epub 2009 Feb 5. The present results suggest that presynaptic glycine receptors on excitatory nerve terminals might play an important role in the excitability of the dentate gyrus-hilus-CA3 network in physiological and/or pathological conditions. This facilitatory effect of was blocked by 1 microM strychnine, a specific glycine receptor antagonist, but was not affected by 30 microM picrotoxin. |
1(0,0,0,1) | Details |
| 17681355 | Kilb W, Sinning A, Luhmann HJ: Model-specific effects of bumetanide on epileptiform activity in the in-vitro intact hippocampus of the newborn mouse. Neuropharmacology. 2007 Sep;53(4):524-33. Epub 2007 Jun 30. To evaluate whether bumetanide consistently attenuates epileptiform activity, we investigated the effect of 10 microM bumetanide in five different in-vitro epilepsy models using field potential recordings in the CA3 region of intact mouse hippocampal preparations at postnatal day 4-7. Inhibition of ligand-gated Cl (-) channels by 10 microM gabazine and 30 microM strychnine induced interictal activity (IA) that was only marginally affected by bumetanide. |
1(0,0,0,1) | Details |
| 15288514 | Peterson SL, Purvis RS, Griffith JW: Differential neuroprotective effects of the NMDA receptor-associated site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus. Neurotoxicology. 2004 Sep;25(5):835-47. The present study determined whether 1-aminocyclopropanecarboxylic acid (ACPC) or D-cycloserine (DCS), both partial agonists of the strychnine-insensitive site on the NMDA receptor ionophore complex, exerted anticonvulsant or neuroprotectant activity in Li-pilo SE. In contrast, when administered as exposure treatment ACPC enhanced the neural damage in the thalamus and CA3 of the hippocampus suggesting the neuropathology in those regions is mediated by a different subset of NMDA receptors. |
1(0,0,0,1) | Details |