Protein Information

Name MT2
Synonyms MEL 1B R; MT2; MTNR1B; Mel1BR; Mel1b melatonin receptor; Melatonin receptor 1B; Melatonin receptor type 1B; Mel1BRs…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
17921866 Zhang M, Cao LH, Yang XL: Melatonin modulates glycine currents of retinal ganglion cells in rat. Neuroreport. 2007 Oct 29;18(16):1675-8.

By using patch clamp techniques, we demonstrate for the first time that glycine-induced currents from a population of isolated ganglion cells in the rat retina are potentiated by melatonin of nanomolar concentrations by increasing the efficacy and the channel conductance of the strychnine-sensitive glycine receptor.
The melatonin effect is blocked by 4-P-PDOT, indicating the mediation of the MT2 receptor.
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11024498 Bradley KN, Rowan EG, Harvey AL: Effects of brucine, a plant alkaloid, on M (1) muscarinic receptors and alpha (1)-adrenoceptors in the rabbit vas deferens preparation. Toxicon. 2001 Apr;39(4):581-7.


The plant alkaloid brucine is an analogue of strychnine and is known to be an allosteric modulator at cloned M (1) muscarinic receptors.
0(0,0,0,0) Details