Protein Information

Name Delta opioid receptors
Synonyms Delta type opioid receptor; Delta type opioid receptor; OPRD; OPRD 1; OPRD1; delta opioid receptor; delta1 opioid receptor; Delta type opioid receptors…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
7472439 Randic M, Cheng G, Kojic L: kappa-opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord. J Neurosci. 1995 Oct;15(10):6809-26.

Monosynaptic and polysynaptic excitatory postsynaptic potentials (EPSPs) were evoked by orthodromic electrical stimulation of A delta or C primary afferent fibers in the dorsal root after blocking inhibitory inputs with bicuculline and strychnine, NMDA receptors with D-2-amino-5-phosphonovaleric acid and mu- and delta-opioid receptors with CTAP and ICI 174,864, respectively.
32(0,1,1,2) Details
14656295 Tambeli CH, Quang P, Levine JD, Gear RW: Contribution of spinal inhibitory receptors in heterosegmental antinociception induced by noxious stimulation. Eur J Neurosci. 2003 Dec;18(11):2999-3006.

Importantly, noxious stimulus-induced antinociception (NSIA) is mediated by endogenous opioids (as well as other neurotransmitters) in nucleus accumbens, as indicated by the ability of intra-accumbens administration of mu- or delta-opioid receptor antagonists to block NSIA.
We report that spinal administration of selective antagonists for mu-opioid (Cys2, Tyr3, Orn5, Pen7amide), kappa-opioid (nor-binaltorphimine), GABA-A (bicuculline), GABA-B (CGP 35348) and glycine (strychnine) receptors significantly reduced NSIA.
1(0,0,0,1) Details
15788776 Hack SP, Bagley EE, Chieng BC, Christie MJ: Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. J Neurosci. 2005 Mar 23;25(12):3192-8.

1(0,0,0,1) Details