| Name | serotonin receptors (protein family or complex) |
|---|---|
| Synonyms | 5 Hydroxytryptamine receptor; 5 Hydroxytryptamine receptors; 5 hydroxytryptamine 3 receptor; 5 hydroxytryptamine 3 receptors; serotonin receptor; serotonin receptors |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15566307 | Maksay G, Nemes P, Biro T: Synthesis of tropeines and allosteric modulation of ionotropic glycine receptors. J Med Chem. 2004 Dec 2;47(25):6384-91. These (nor) tropeines inhibited [(3) H] strychnine binding to glycine receptors in synaptosomal membranes of rat spinal cord. Displacing potencies were also measured for [(3) H] granisetron binding to 5-HT (3) type serotonin receptors of rat cerebral cortex. |
1(0,0,0,1) | Details |
| 9927615 | Rothlin CV, Katz E, Verbitsky M, Elgoyhen AB: The alpha9 nicotinic acetylcholine receptor shares pharmacological properties with type A and type 3 serotonin receptors. Mol Pharmacol. 1999 Feb;55(2):248-54. Thus, the type A gamma-aminobutyric acid receptor antagonist bicuculline, the glycinergic antagonist strychnine, and the type 3 serotonin receptor antagonist ICS-205,930 block -evoked currents in alpha9-injected Xenopus laevis oocytes with the following rank order of potency: strychnine > ICS-205,930 > bicuculline. |
1(0,0,0,1) | Details |
| 17234181 | Mascia MP, Bachis E, Obili N, Maciocco E, Cocco GA, Sechi GP, Biggio G: Thiocolchicoside inhibits the activity of various subtypes of recombinant (A) receptors expressed in Xenopus laevis oocytes. Eur J Pharmacol. 2007 Mar 8;558(1-3):37-42. Epub 2006 Dec 12. Thiocolchicoside inhibited the function of recombinant human strychnine-sensitive glycine receptors composed of the alpha1 subunit with a potency (median inhibitory concentration of 47 microM) lower than that apparent with recombinant (A) receptors. |
0(0,0,0,0) | Details |
| 12743679 | Gandolfi O, Voltattorni M, Gaggi R, Dall'Olio R: Repeated administration of the novel antipsychotic does not modulate -sensitive and 5HT2 serotonin receptors in rats. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):615-20. Epub 2003 May 13. Since the binding of the radiolabelled channel blocker [3H]-MK801 is generally considered an affordable index of -sensitive glutamate receptor activation, we examined the effects of clinically effective treatment (3 weeks, daily administration) of the atypical antipsychotic drug (32 micromol/kg/5 ml) on the specific binding of [3H]-MK801 specific binding and on the strychnine-insensitive sites B) in synaptic plasma membranes (SPM) prepared from the medial prefrontal cortex (mPFC) of rats sacrificed after different (24, 60, 120 h) washout periods. |
0(0,0,0,0) | Details |