| Name | NR2B |
|---|---|
| Synonyms | GRIN2B; Glutamate [NMDA] receptor subunit epsilon 2; Glutamate [NMDA] receptor subunit epsilon 2 precursor; N methyl D aspartate receptor subtype 2B; N methyl D aspartate receptor subunit 2B; N methyl D aspartate receptor subunit 3; NMDAR2B; NR2B… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9758163 | Paudice P, Gemignani A, Raiteri M: Evidence for functional native NMDA receptors activated by or alone in the absence of glutamatergic coagonist. Eur J Neurosci. 1998 Sep;10(9):2934-44. This effect of was strychnine-insensitive and could be mimicked by a stereoselective agonist at the NMDA receptor site. The neuropeptide release elicited by was strongly inhibited by ifenprodil (0.3 microM) and by Zn2+ ions (50 nM), selective ligands at the NR2B and NR2A subunits of NMDA receptors, respectively. |
2(0,0,0,2) | Details |
| 15490133 | Barth A, Nguyen LB, Barth L, Newell DW: -induced neurotoxicity in organotypic hippocampal slice cultures. Exp Brain Res. 2005 Mar;161(3):351-7. Epub 2004 Oct 14. Purely excitatory glycine receptors composed of NR1 and NR3/NR4 NMDA receptor subunits have recently been described, raising the possibility of excitotoxic effects mediated by alone. Stimulation or inhibition (strychnine) of the inhibitory strychnine-sensitive glycine receptors did not produce any neurotoxicity. |
1(0,0,0,1) | Details |
| 8558453 | Standaert DG, Testa CM, Rudolf GD, Hollingsworth ZR: Inhibition of glutamate receptor subunit expression by antisense oligonucleotides reveals their role in striatal motor regulation. J Pharmacol Exp Ther. 1996 Jan;276(1):342-52. After NMDAR1 antisense ODN injection, striatal binding of 3H- to sites was not altered, although strychnine-insensitive 3H- binding sites exhibited a small but significant reduction. In situ hybridization demonstrated that injection of the NMDAR1, NMDAR2A or NMDAR2B antisense ODNs produced specific reductions in target mRNA signal intensity in the injected striatum. |
1(0,0,0,1) | Details |
| 11698028 | Parsons CG: NMDA receptors as targets for drug action in neuropathic pain. Eur J Pharmacol. 2001 Oct 19;429(1-3):71-8. Functional inhibition of NMDA receptors can be achieved through actions at different recognition sites such as the primary transmitter site (competitive), strychnine-insensitive site (B)), polyamine site (NR2B selective) and phencyclidine site located inside the cationic channel. |
32(0,1,1,2) | Details |
| 17502428 | Smothers CT, Woodward JJ: Pharmacological characterization of -activated currents in HEK 293 cells expressing NR1 and NR3 subunits. J Pharmacol Exp Ther. 2007 Aug;322(2):739-48. Epub 2007 May 14. |
2(0,0,0,2) | Details |
| 15888962 | Leewanich P, Tohda M, Takayama H, Sophasan S, Watanabe H, Matsumoto K: Corymine potentiates -induced currents in Xenopus oocytes expressing NR1a/NR2B glutamate receptors. J Pharmacol Sci. 2005 May;98(1):58-65. Epub 2005 May 12. Previous studies demonstrated that corymine, an indole alkaloid isolated from the leaves of Hunter zeylanica, dose-dependently inhibited strychnine-sensitive -induced currents. |
2(0,0,0,2) | Details |
| 19523966 | Mok MH, Fricker AC, Weil A, Kew JN: Electrophysiological characterisation of the actions of at ligand-gated ion channels. Neuropharmacology. 2009 Sep;57(3):242-9. Epub 2009 Jun 11. Using whole-cell patch-clamp recordings, we found that kynA was a more potent antagonist at human NR1a/NR2A compared with NR1a/NR2B receptors (IC (50): 158 muM and 681 muM, respectively; in 30 muM KynA inhibited AMPA-evoked currents to a similar degree in cultured hippocampal neurons and a human GluR2 (flip/unedited) cell line (IC (50): 433 and 596 muM, respectively) and at higher concentrations, kynA also inhibited the strychnine-sensitive glycine receptor ( approximately 35% inhibition by 3 mM kynA). |
1(0,0,0,1) | Details |
| 18554813 | Cervetto C, Taccola G: GABAA and strychnine-sensitive glycine receptors modulate -evoked release from rat spinal motoneurons: a possible role in neuroprotection. Neuroscience. 2008 Jul 17;154(4):1517-24. Epub 2008 May 3. -mediated [(3) H] release was completely prevented by MK-801, 5,7-diclorokynurenic acid and ifenprodil, while it was strongly inhibited by a lower external pH, suggesting that the involved NMDA receptors contain NR1 and NR2B subunits. |
1(0,0,0,1) | Details |
| 15356198 | Carpenter-Hyland EP, Woodward JJ, Chandler LJ: Chronic induces synaptic but not extrasynaptic targeting of NMDA receptors. J Neurosci. 2004 Sep 8;24(36):7859-68. Similar effects were observed with NR2B clustering after chronic exposure. |
1(0,0,0,1) | Details |
| 20092573 | Reed BT, Sullivan SJ, Tsai G, Coyle JT, Esguerra M, Miller RF: The transporter GlyT1 controls receptor coagonist occupancy in the mouse retina. Eur J Neurosci. 2009 Dec;30(12):2308-17. Epub 2009 Dec 10. The interpretation of these studies was simplified by blocking post-synaptic inhibition with picrotoxinin and strychnine. Immunoblots of NMDA receptor subunits (NR1, NR2A and NR2B) in WT and GlyT1 (-/+) animals showed that the NR1 subunits were identical. |
1(0,0,0,1) | Details |