| Name | muscles |
|---|---|
| Synonyms | COX 7a M; COX VIIa M; COX7A; COX7A1; COX7A1 protein; COX7AH; COX7AM; Cytochrome c oxidase subunit 7a H… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8233086 | Droge MH, Tao Y: effects on in vitro motor pattern generation in mouse spinal cord. . Neurosci Lett. 1993 Aug 20;158(2):139-42. Strychnine application resulted in synchronized EMG bursting in G and TA muscles, suggesting that 1 receptor activation does provide some reciprocal inhibition between the G and TA motor nuclei. |
32(0,1,1,2) | Details |
| 10036251 | Nichols TR: Receptor mechanisms underlying heterogenic reflexes among the triceps surae muscles of the cat. J Neurophysiol. 1999 Feb;81(2):467-78. The inhibition outlasted the excitation and was blocked by intravenous strychnine. |
7(0,0,0,7) | Details |
| 11499889 | Greene R, Meatherall R: Dermal exposure to strychnine. . J Anal Toxicol. 2001 Jul-Aug;25(5):344-7. About 24 h after cleaning up a strychnine spill, a 50-year-old woman presented to the emergency department with classical signs of strychnine poisoning, consisting of marked pain in the muscles of her lower limbs, dermal sensitivity, and stiffness in her jaw. |
6(0,0,1,1) | Details |
| 8492110 | Kitchener PD, Laing NG: Brachially innervated ectopic hindlimbs in the chick embryo. J Neurobiol. 1993 Mar;24(3):335-43. However, the virtually immobile grafted hindlimbs of E20 embryos exhibited strong, synchronous contractions of gastrocnemius and tibialis muscles upon intraperitoneal injection of strychnine (20 micrograms). |
6(0,0,1,1) | Details |
| 17880397 | Ethier C, Brizzi L, Giguere D, Capaday C: Corticospinal control of antagonistic muscles in the cat. Eur J Neurosci. 2007 Sep;26(6):1632-41. Following intravenous injection of a single bolus of strychnine, a cortical point at which only a physiological flexor was previously activated also elicited simultaneous activation of its antagonist. |
4(0,0,0,4) | Details |
| 15928085 | Hirata H, Saint-Amant L, Downes GB, Cui WW, Zhou W, Granato M, Kuwada JY: Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8345-50. Epub 2005 May 31. Bilateral alternation of muscle contractions requires reciprocal inhibition between the two sides of the hindbrain and spinal cord, and disruption of this inhibition should lead to simultaneous activation of bilateral muscles. Similar simultaneous contractions are observed in wild-type embryos treated with strychnine, a blocker of the inhibitory glycine receptor (GlyR). |
3(0,0,0,3) | Details |
| 8201405 | Bonasera SJ, Nichols TR: Mechanical actions of heterogenic reflexes linking long toe flexors with ankle and knee extensors of the cat hindlimb. J Neurophysiol. 1994 Mar;71(3):1096-110. Further, the heterogenic inhibition between FHL/G and FHL/S was attenuated by strychnine infusion (intravenous) but unaffected by either mecamylamine, picrotoxin, or baclofen infusion (intravenous, intrathecal). Mutual Ia synergism previously described for these two muscles provides a basis for all of the above findings. |
3(0,0,0,3) | Details |
| 10485027 | Il'ina-Kakueva EI, Kaplanskii AS: [The effect of support loads and CNS stimulants on the development of the atrophic process in the muscles of suspended rats]. Aviakosm Ekolog Med. 1999;33(3):20-5. The histomorphometric method there was used to study effects of ephedrine, strychnine, and support loads on the atrophy of m. soleus and m. gastrocnemius in rats with load-deprived lower extremities (14-day tail-suspension). |
2(0,0,0,2) | Details |
| 9874519 | Kogo M, Tanaka S, Chandler SH, Matsuya T: Examination of the relationships between jaw opener and closer rhythmical muscle activity in an in vitro brainstem jaw-attached preparation. Somatosens Mot Res. 1998;15(3):200-10. In the majority of preparations examined, where a defined region of brainstem was isolated and the neuronal innervation of the jaw opener and closer muscles was left intact, bath application of the excitatory amino acid agonist N-methyl-D,L- (NMA, 20-40 microM) in combination with bicuculline (BIC 10 microM), a (A) antagonist, produced rhythmical electromyogram (EMG) activity in jaw opener and closer muscles, bilaterally, in conjunction with rhythmical jaw movements. Similarly, NMA application in combination with the antagonist strychnine (STR, 10 microM), also produced rhythmical EMG activity from both opener and closer muscles, ipsilaterally, but showed no temporal coordination between the antagonist muscle pair. |
2(0,0,0,2) | Details |
| 19944082 | Okamoto R, Enomoto A, Koizumi H, Tanaka S, Ishihama K, Kogo M: Long-term potentiation of intrinsic excitability in trigeminal motoneurons. Brain Res. 2010 Feb 2;1312:32-40. Epub 2009 Nov 26. Trigeminal motoneurons (TMNs) relay the final output signals generated within the oral-motor pattern-generating circuits to the jaw muscles for execution of various patterns of motor activity. |
1(0,0,0,1) | Details |
| 9143005 | Kimura N, Perry SF, Remmers JE: Strychnine eliminates reciprocation and augmentation of respiratory bursts of the in vitro frog brainstem. Neurosci Lett. 1997 Mar 28;225(1):9-12. We have recorded rhythmic bursts of efferent action potentials from nerves of respiratory muscles in the frog (Rana pipiens), using a modified in vitro preparation, in which the brainstem lies in situ in the ventral half of the skull. |
1(0,0,0,1) | Details |
| 12803679 | Rehman HU: Babinski sign. Neurologist. 2002 Sep;8(5):316-8. He also illustrated that it was present in infancy and transiently appeared in epilepsy and strychnine poisoning. The sign emerges when the dysfunction of the pyramidal tract involves the fibers that project on motoneurons of foot muscles and is mediated by extensor hallucis longus. |
1(0,0,0,1) | Details |
| 19091929 | Sanchez A, Mustapic S, Zuperku EJ, Stucke AG, Hopp FA, Stuth EA: Role of inhibitory neurotransmission in the control of canine hypoglossal motoneuron activity in vivo. J Neurophysiol. 2009 Mar;101(3):1211-21. Epub 2008 Dec 17. Hypoglossal motoneurons (HMNs) innervate all tongue muscles and are vital for maintenance of upper airway patency during inspiration. Multibarrel micropipettes were used to record extracellular unit activity of individual IHMNs during local antagonism of (A) receptors with bicuculline and picrotoxin or glycine receptors with strychnine. |
1(0,0,0,1) | Details |
| 9026324 | Rasoanaivo P, Ratsimamanga-Urverg S, Frappier F: [Recent results on the pharmacodynamics of Strychnos malgaches alkaloids] . Sante. 1996 Jul-Aug;6(4):249-53. Investigation of Strychnos (Loganiaceae) shrubs and trees was initiated by their traditional uses of their inherent poisons on arrows: this led to the discovery of strychnine and curare alkaloids. Subsequently, phytochemical investigation of several Strychnos species has shown great structural diversity of the alkaloid constituent which also display various biological effects, i.e. convulsive and relaxant effects on muscles, and antimicrobial, antitumor and antihypertensive properties. |
1(0,0,0,1) | Details |
| 17977928 | Gabriel JP, Mahmood R, Walter AM, Kyriakatos A, Hauptmann G, Calabrese RL, El Manira A: Locomotor pattern in the adult zebrafish spinal cord in vitro. J Neurophysiol. 2008 Jan;99(1):37-48. Epub 2007 Oct 31. Application of elicited rhythmic locomotor activity that was monitored by recording from muscles or ventral roots in semi-intact or isolated spinal cord preparations, respectively. Blockade of glycinergic synaptic transmission by strychnine switched the alternating activity into synchronous bursting in the left and right sides as well as along the rostrocaudal axis. |
1(0,0,0,1) | Details |
| 12663257 | Chen Z, Travers JB: Inactivation of amino acid receptors in medullary reticular formation modulates and suppresses ingestion and rejection responses in the awake rat. Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R68-83. Epub 2003 Mar 27. Bilateral infusions of the (A) receptor antagonist bicuculline or the glycine receptor antagonist strychnine enhanced the amplitude of IO stimulation-induced oral responses. Bilateral microinjection of the (NMDA) receptor antagonist d-[(3)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (D-CPP) suppressed licking and gape responses recorded electromyographically from a subset of orolingual muscles. |
1(0,0,0,1) | Details |
| 10591891 | Jovanovic K, Petrov T, Stein RB: Effects of inhibitory neurotransmitters on the mudpuppy (Necturus maculatus) locomotor pattern in vitro. Exp Brain Res. 1999 Nov;129(2):172-84. During -induced locomotion, the rhythmic motor output (EMG) was recorded unilaterally from elbow flexor and extensor muscles. Addition of glycine receptor antagonist strychnine or (A) receptor antagonist bicuculline disrupted the phase relationship between antagonistic motor pools during ongoing locomotion, thereby changing the normal alternating pattern into synchronous EMG bursts. |
1(0,0,0,1) | Details |
| 8334524 | Kubin L, Kimura H, Tojima H, Davies RO, Pack AI: Suppression of hypoglossal motoneurons during the carbachol-induced atonia of REM sleep is not caused by fast synaptic inhibition. Brain Res. 1993 May 21;611(2):300-12. The inhibitory amino acid receptor antagonists, strychnine (glycine receptors) or bicuculline (GABAA receptors), were injected (100-250 nl; 1.0-2.5 mM) into one XII nucleus (the other served as control) in an attempt to reduce or abolish the depression subsequently induced by pontine carbachol. In acutely decerebrate cats, carbachol induces postural atonia, eye movements and a depression of the motor output to respiratory pump and upper airway muscles. |
1(0,0,0,1) | Details |
| 18463181 | Wang Z, Li L, Goulding M, Frank E: Early postnatal development of reciprocal Ia inhibition in the murine spinal cord. J Neurophysiol. 2008 Jul;100(1):185-96. Epub 2008 May 7. The pathway mediating reciprocal inhibition from muscle spindle afferents (Ia axons) to motoneurons (MNs) supplying antagonist muscles has been well studied in adult cats, but little is known about how this disynaptic pathway develops. Synaptic potentials in PBSt MNs evoked by Q nerve stimulation are mediated disynaptically and are blocked by strychnine, implying that is the major inhibitory transmitter as in adult cats. |
1(0,0,0,1) | Details |
| 12412642 | Chan TY: Herbal medicine causing likely strychnine poisoning. Hum Exp Toxicol. 2002 Aug;21(8):467-8. One hour after she drank the second bowl of herbal decoction, she suddenly developed tonic contractions of all her limb muscles and carpopedal spasm lasting 5 min, difficulty in breathing, chest discomfort and perioral numbness. |
1(0,0,0,1) | Details |
| 12137420 | Meiser H, Hagedorn HW: Atypical time course of clinical signs in a dog poisoned by strychnine. . Vet Rec. 2002 Jul 6;151(1):21-4. |
0(0,0,0,0) | Details |
| 8887023 | Tortoriello J, Aguilar-Santamaria L: Evaluation of the -antagonist, antidiarrhoeic and central nervous system activities of Baccharis serraefolia. J Ethnopharmacol. 1996 Sep;53(3):157-63. In the present work, the methanolic extract of B. serraefolia significantly delayed the onset of tonic seizures induced by strychnine and pentylenetetrazol; besides, it diminished the death rate and number of animals that exhibited convulsions. |
0(0,0,0,0) | Details |