| Name | AP4 |
|---|---|
| Synonyms | AP 4; AP4; Activating enhancer binding protein 4; TFAP 4; TFAP4; Transcription factor AP 4; Transcription factor AP4; transcription factor AP 4 (activating enhancer binding protein 4)… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8728878 | Wikinski SI, Acosta GB: [Role of excitatory amino acids in neuropathology] . Medicina (B Aires). 1995;55(4):355-65. Along with the site for which binds and/or there have been identified a site for the binding of (which is different from the strychnine sensitive one), a site for poliamines such as and and a site for the binding of Zn2+ (Table 1). There are two metabotropic type receptors: L-AP4 and trans-ACPD. |
1(0,0,0,1) | Details |
| 15790752 | Mueller PJ, Foley CM, Vogl HW, Hay M, Hasser EM: Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors. Am J Physiol Regul Integr Comp Physiol. 2005 Jul;289(1):R198-208. Epub 2005 Mar 24. Previous studies have demonstrated that microinjection of the putative group III metabotropic glutamate receptor (mGluR) agonist, l (+)-2-amino-4-phosphonobutyric acid (L-AP4), into the nucleus tractus solitarius (NTS) produces depressor and sympathoinhibitory responses. Microinjection of (0.02-20 mM) failed to mimic sympathoinhibitory responses to L-AP4, even in the presence of the inhibitory antagonist, strychnine (3 mM). |
9(0,0,0,9) | Details |
| 7506752 | Thoreson WB, Miller RF: Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina. J Neurophysiol. 1993 Oct;70(4):1326-38. AMPA-evoked currents exhibited a significant dependence and were suppressed by -A (GABAA) antagonists bicuculline and picrotoxin; a uptake blocker, nipecotic acid; and a antagonist, strychnine. At the holding potential of -50 mV, L-2-amino-4-phosphonobutanoic acid (L-AP4, 5-10 microM) evoked an outward current accompanied by a conductance decrease. |
7(0,0,0,7) | Details |
| 8622124 | Euler T, Schneider H, Wassle H: responses of bipolar cells in a slice preparation of the rat retina. J Neurosci. 1996 May 1;16(9):2934-44. the specific agonists (+/-)-2-amino-4-phosphonobutyric acid (AP-4) and kainate (KA), and the antagonist 6-cyanoquinoxaline-2,3-dione (CNQX) were applied. The cells could be isolated from presynaptic influences by the co-application of bicuculline, strychnine, and ions. |
3(0,0,0,3) | Details |
| 14988037 | Huang H, Luo DG, Shen Y, Zhang AJ, Yang R, Yang XL: AMPA receptor is involved in transmission of cone signal to ON bipolar cells in carp retina. Brain Res. 2004 Mar 26;1002(1-2):86-93. On the other hand, alpha-amino-3--5-methyl-4-isoxazolepropionic acid (AMPA) of 20 microM caused a membrane depolarization and blocked depolarizing light responses, L-2-amino-4-phosphonobutryic acid (l-AP4) was without effect. The effects of AMPA were reversed by coapplication of GYKI 52466, an AMPA receptor selective non-competitive antagonist, but persisted in the presence of picrotoxin and strychnine. |
3(0,0,0,3) | Details |
| 19017536 | Zhang HM, Chen SR, Pan HL: Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain. Neuroscience. 2009 Jan 23;158(2):875-84. Epub 2008 Oct 30. The group III mGluR agonist l (+)-2-amino-4-phosphonbutyric acid (l-AP4) produced a greater inhibition of the amplitude of monosynaptic and polysynaptic evoked EPSCs in nerve-injured rats than in control rats. l-AP4 inhibited the frequency of miniature EPSCs in 66.7% of neurons in control rats but its inhibitory effect was observed in all neurons tested in nerve-injured rats. |
2(0,0,0,2) | Details |
| 19571128 | Crook JD, Davenport CM, Peterson BB, Packer OS, Detwiler PB, Dacey DM: Parallel ON and OFF cone bipolar inputs establish spatially coextensive receptive field structure of blue-yellow ganglion cells in primate retina. J Neurosci. 2009 Jul 1;29(26):8372-87. ON pathway block with l-AP-4, the mGluR6 receptor agonist, abolished the S-ON response but spared the LM-OFF response. The GABAa/c receptor antagonist picrotoxin and the glycine receptor antagonist strychnine did not affect chromatic balance or the basic coextensive receptive field structure, suggesting that the LM-OFF field is not generated by an inner retinal inhibitory pathway. |
1(0,0,0,1) | Details |
| 15229213 | Wong KY, Adolph AR, Dowling JE: Retinal bipolar cell input mechanisms in giant danio. J Neurophysiol. 2005 Jan;93(1):84-93. Epub 2004 Jun 30. In CPPG or l-AP4 (l-(+)-2-amino-4-phosphonobutyric acid, a group III mGluR agonist), the sensitivity of the b-wave to the green stimulus was dramatically reduced and the b-waves elicited by the 2 stimuli became nearly matched. Picrotoxin, strychnine, and tetrodotoxin were used to isolate the effects of the analogs to the photoreceptor-bipolar cell synapse. |
1(0,0,0,1) | Details |
| 8401927 | Ishida M, Saitoh T, Shimamoto K, Ohfune Y, Shinozaki H: A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord. Br J Pharmacol. 1993 Aug;109(4):1169-77. Depression of monosynaptic excitation caused by DCG-IV was not affected by any known pharmacological agents, including 2-amino-3-phosphonopropanoic acid (AP3), diazepam, 2-hydroxysaclofen, picrotoxin and strychnine. 6. DCG-IV was more effective than L-CCG-I, (1S,3R)-ACPD or L-2-amino-4-phosphonobutanoic acid (L-AP4) in reducing the monosynaptic excitation of motoneurones. 4. |
1(0,0,0,1) | Details |
| 18497354 | Petit-Jacques J, Bloomfield SA: Synaptic regulation of the light-dependent oscillatory currents in starburst amacrine cells of the mouse retina. J Neurophysiol. 2008 Aug;100(2):993-1006. Epub 2008 May 21. Strychnine, the blocker of glycine receptors did not affect the initial peak but strongly decreased the oscillations frequency. The synaptic pathway responsible for the light responses was blocked by AP4, an agonist of metabotropic glutamate receptors that hyperpolarize on-center bipolar cells on activation. |
1(0,0,0,1) | Details |
| 11516417 | Su CK: Intraspinal amino acid neurotransmitter activities are involved in the generation of rhythmic sympathetic nerve discharge in newborn rat spinal cord. Brain Res. 2001 Jun 15;904(1):112-25. In contrast, strychnine (Stry, glycine receptor antagonist) consistently reduced qSND in a dose-dependent manner. Bic-induced bSND was reversibly abolished by CNQX or L-AP4. |
1(0,0,0,1) | Details |
| 7529821 | Amato A, Ballerini L, Attwell D: Intracellular pH changes produced by uptake in rat hippocampal slices. J Neurophysiol. 1994 Oct;72(4):1686-96. The -evoked acidification was not significantly reduced by blockers of -gated ion channels [6-cyano-7-nitroquinoxaline-2,3- dione (CNQX) and D-aminophosphonovalerate (APV)] nor by blockers of - and -gated channels (picrotoxin and strychnine), and so was not produced by H+ entry through alpha-amino-3--5-methyl-4- isoxazolepropionic acid (AMPA) or (NMDA) receptor channels nor by HCO3- exit through the channels controlled by or 4. It was also unaffected by saturation of presynaptic L-amino-4-phosphonobutanoate (AP4) receptors with AP4. 5. |
1(0,0,0,1) | Details |
| 7884467 | Pinco M, Lev-Tov A: Synaptic transmission between ventrolateral funiculus axons and lumbar motoneurons in the isolated spinal cord of the neonatal rat. J Neurophysiol. 1994 Nov;72(5):2406-19. Addition of the GABAB receptor agonist L-(-) baclofen or the analogue L-2-amino-4-phosphonobutyric acid (L-AP4) attenuated the pharmacologically resolved short-latency EPSPs.(ABSTRACT TRUNCATED AT 400 WORDS) These depolarizing PSPs were blocked by addition of strychnine and bicuculline and are therefore suggested to be and -A (GABAA) receptor-mediated inhibitory PSPs. |
1(0,0,0,1) | Details |
| 7538566 | Grant GB, Dowling JE: -activated current in cone-driven ON bipolar cells of the white perch retina. J Neurosci. 1995 May;15(5 Pt 2):3852-62. IGlu was not blocked by 100 microM picrotoxin or 1 microM strychnine, indicating that it was not caused by inhibitory input. |
0(0,0,0,0) | Details |
| 18417693 | Manookin MB, Beaudoin DL, Ernst ZR, Flagel LJ, Demb JB: Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight. J Neurosci. 2008 Apr 16;28(16):4136-50. Furthermore, the CNQX/d-AP-5-resistant response was blocked by l-AP-4, meclofenamic acid, quinine, or strychnine but not by bicuculline. |
0(0,0,0,0) | Details |
| 8624016 | Onaka M, Minami T, Nishihara I, Ito S: Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice. Anesthesiology. 1996 May;84(5):1215-22. |
0(0,0,0,0) | Details |