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Yin H, Lee KE, Park SA, Bhattarai JP, Suh BJ, Jeon JG, Kim BG, Park SJ, Han SK: Inhibitory effects of somatostatin on the substantia gelatinosa neurons of trigeminal subnucleus caudalis via somatostatin type 2 receptors in juvenile mice. Brain Res. 2009 Dec 22;1304:49-56. Epub 2009 Sep 24.
The SST-induced hyperpolarizing response was maintained in the presence of TTX (Na (+) channel blocker), AP-5 (NMDA receptor antagonist), CNQX (non-NMDA glutamate receptor antagonist), picrotoxin (GABA (A) receptor antagonist) and strychnine (glycine receptor antagonist), respectively, suggesting that SST has direct effects on the postsynaptic SG neurons.
In addition, SSTR2 mRNA expression was detected on the SG neurons using single cell RT-PCR in juvenile mice. |
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