| Name | transducin |
|---|---|
| Synonyms | G protein alpha transducing 1; GBT 1; GBT1; GNAT 1; GNAT1; GNATR; Guanine nucleotide binding protein G(T) alpha 1 subunit; Guanine nucleotide binding protein alpha transducing activity polypeptide 1… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10449792 | Ming D, Ninomiya Y, Margolskee RF: Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9903-8. We have monitored this activation with an in vitro assay to identify compounds that inhibited taste receptor activation of transducin by bitter tastants: AMP and chemically related compounds inhibited in vitro responses to several bitter compounds (e.g., denatonium, quinine, strychnine, and atropine). |
33(0,1,1,3) | Details |
| 17253962 | Sainz E, Cavenagh MM, Gutierrez J, Battey JF, Northup JK, Sullivan SL: Functional characterization of human bitter taste receptors. . Biochem J. 2007 May 1;403(3):537-43. We also demonstrate that hT2R14 is a receptor for aristolochic acid and report the first characterization of the ligand specificities of hT2R7, which is a broadly tuned receptor responding to strychnine, quinacrine, chloroquine and papaverine. Using these defined ligand-receptor interactions, we assayed the ability of the ligand-activated T2Rs to catalyse GTP binding on divergent members of the G (alpha) family including three members of the G (alphai) subfamily (transducin, G (alphai1) and G (alphao)) as well as G (alphas) and G (alphaq). |
1(0,0,0,1) | Details |
| 9671782 | Ming D, Ruiz-Avila L, Margolskee RF: Characterization and solubilization of bitter-responsive receptors that couple to gustducin. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8933-8. In this paper, we show that gustducin is expressed in bovine taste tissue and that both gustducin and transducin, in the presence of bovine taste membranes, can be activated specifically by several bitter compounds, including denatonium, quinine, and strychnine. |
34(0,1,1,4) | Details |