Protein Information

Name NA K ATPase
Synonyms (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
14585753 Kurup RK, Kurup PA: A hypothalamic digoxin-mediated model for autism. . Int J Neurosci. 2003 Nov;113(11):1537-59.

Digoxin can also preferentially upregulate tryptophan transport over tyrosine resulting in increased levels of depolarizing tryptophan catabolites--serotonin, quinolinic acid (NMDA agonist), strychnine (blocks glycinergic inhibitory transmission), and nicotine (promotes dopamine release) and decreased levels of hyperpolarizing tyrosine catabolites--dopamine, noradrenaline, and morphine--contributing to membrane Na+-K+ ATPase inhibition.
85(1,1,1,5) Details
12888426 Kurup RK, Kurup PA: Hypothalamic digoxin, hemispheric chemical dominance, and eating behavior. Int J Neurosci. 2003 Aug;113(8):1127-41.

The serum HMG CoA reductase activity, RBC membrane Na+-K+ ATPase activity, serum digoxin, magnesium, tryptophan catabolites (serotonin, quinolinic acid, strychnine, and nicotine), and tyrosine catabolites (morphine, dopamine, and noradrenaline) were measured in anorexia nervosa, bulimia nervosa, right hemispheric dominant, left hemispheric dominant, and bihemispheric dominant individuals.
83(1,1,1,3) Details
12881188 Kurup RK, Kurup PA: The concept of cerebral chemical dominance. Int J Neurosci. 2003 Jul;113(7):957-70.

The serum magnesium, RBC membrane Na+-K+ ATPase activity and serum ubiquinone levels were reduced in all right hemispheric dominant individuals and 50% of left hemispheric dominant individuals.
The tryptophan-derived neurotransmitters--serotonin, quinolinic acid, strychnine, and nicotine--were increased while the tyrosine derived neurotransmitters--dopamine, noradrenaline, and morphine--were reduced in all right hemispheric dominant individuals and 50% of left hemispheric dominant individuals.
2(0,0,0,2) Details
12745627 Kurup RK, Kurup PA: Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis. Int J Neurosci. 2003 May;113(5):683-701.

The isoprenoid metabolites--digoxin, dolichol, and ubiquinone--RBC membrane Na+-K+ ATPase activity, serum magnesium and tyrosine/tryptophan catabolic patterns were assessed.
There were increased levels of tryptophan catabolites--nicotine, strychnine, quinolinic acid, and serotonin--and decreased levels of tyrosine catabolites--dopamine, noradrenaline, and morphine in ME.
2(0,0,0,2) Details
12577094 Kumar AR, Kurup PA: Hypothalamic digoxin and regulation of body mass index. Neurol India. 2002 Dec;50(4):452-8.

The hypothalamus produces digoxin, an endogenous membrane Na+-K+ ATPase inhibitor and regulator of neurotransmission.
The tyrosine catabolites (dopamine, morphine, epinephrine and norepinephrine) were reduced and the tryptophan catabolites (serotonin, quinolinic acid, strychnine and nicotine) were increased.
2(0,0,0,2) Details
12134182 Kumar AR, Kurup PA: Endogenous sodium-potassium ATPase inhibition related biochemical cascade in trisomy 21 and Huntington's disease: neural regulation of genomic function. Neurol India. 2002 Jun;50(2):174-80.

Membrane Na+-K+ ATPase activity, serum magnesium and ubiquinone were decreased while HMG CoA reductase activity, serum digoxin and dolichol levels were increased in both the disorders.
There were increased levels of tryptophan catabolites (nicotine, strychnine, quinolinic acid and serotonin) and decreased levels of tyrosine catabolites (dopamine, noradrenaline and morphine) in both trisomy 21 and Huntington's disease.
1(0,0,0,1) Details
11025626 Ravikumar A, Deepadevi KV, Arun P, Manojkumar V, Kurup PA: Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders. Neurol India. 2000 Sep;48(3):231-8.

Concentration of digoxin, a modulator of amino acid transport, and the activity of HMG CoA reductase, which synthesizes digoxin, were higher in these patients; while RBC membrane Na+-K+ ATPase activity showed a decrease.
On the other hand, strychnine and nicotine were detectable.
1(0,0,0,1) Details