| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8899663 | Rodriguez-Ithurralde D, Olivera S, La Paz A, Vincent O, Rondeau A: effects on glutamate-receptor elicited acetylcholinesterase release from slices and synaptosomes of the spinal ventral horn. J Neurol Sci. 1996 Aug;139 Suppl:76-82. After the 28th postnatal day, nearly all the AChE secreted was released either after the activation of non- glutamate receptors or by strychnine-sensitive GLY-evoked AChE release mechanisms. |
35(0,1,1,5) | Details |
| 7595597 | Rodriguez-Ithurralde D, Olivera S, Migues V, Vincent O, Salazar R: Glutamate-receptor elicited acetylcholinesterase release in mouse spinal cord slice: a model of early excitotoxic injury. J Neurol Sci. 1995 May;129 Suppl:104-6. In the immature slice, potentiated GLU elicited AChE release in the presence of strychnine, suggesting (NMDA) receptor involvement. |
9(0,0,1,4) | Details |
| 7807141 | Rodriguez-Ithurralde D, Vincent O: Excitotoxicity and cholinergic chemical markers during programmed motor neurone death. J Neurol Sci. 1994 Jul;124 Suppl:52-3. Strychnine-resistant stimulation potentiated -induced AChE release, suggesting (NMDA) receptor involvement. |
9(0,0,1,4) | Details |
| 9851655 | Rodriguez-Ithurralde D, Maruri A, Rodriguez X: Motor neurone acetylcholinesterase release precedes neurotoxicity caused by systemic administration of excitatory amino acids and strychnine. J Neurol Sci. 1998 Oct;160 Suppl 1:S80-6. |
8(0,0,1,3) | Details |
| 9600872 | Burgin AM, Szczupak L: Basal release in leech ganglia depolarizes neurons through receptors with a nicotinic binding site. J Exp Biol. 1998 May 21;201 (Pt 12):1907-15. In this study, we analyzed the effects of inhibiting the acetylcholinesterase (AChE) activity in the leech midbody ganglion on the electrophysiological activity of the Retzius neurons. The response to neostigmine and physostigmine was inhibited by curare (100 &mgr;mol l-1), (10 &mgr;mol l-1), atropine (100 &mgr;mol l-1) and strychnine (100 &mgr;mol l-1), but was not affected by mecamylamine (100 &mgr;mol l-1) or hexamethonium (100 &mgr;mol l-1). |
3(0,0,0,3) | Details |
| 9722429 | Marin Burgin A, Szczupak L: Basal release in leech ganglia depolarizes neurons through receptors with a nicotinic binding site. J Exp Biol. 1998 Jun;201(Pt 12):1907-15. In this study, we analyzed the effects of inhibiting the acetylcholinesterase (AChE) activity in the leech midbody ganglion on the electrophysiological activity of the Retzius neurons. The response to neostigmine and physostigmine was inhibited by curare (100 mumol l-1), (10 mumol l-1), atropine (100 mumol l-1) and strychnine (100 mumol l-1), but was not affected by mecamylamine (100 mumol l-1) or hexamethonium (100 mumol l-1). |
3(0,0,0,3) | Details |
| 8476382 | Fishkin RJ, Ince ES, Carlezon WA Jr, Dunn RW: D-cycloserine attenuates -induced learning and memory deficits in rats. Behav Neural Biol. 1993 Mar;59(2):150-7. Acetylcholinesterase inhibitors (AChEIs) have been shown to attenuate these deficits. D-Cycloserine (DCS), a partial agonist at the strychnine-insensitive site on the (NMDA) receptor complex, was investigated for its effects on -induced dementia in the MWM and T-maze paradigms. |
2(0,0,0,2) | Details |
| 17011596 | Zhao X, Marszalec W, Toth PT, Huang J, Yeh JZ, Narahashi T: In vitro galantamine-memantine co-application: mechanism of beneficial action. Neuropharmacology. 2006 Dec;51(7-8):1181-91. Epub 2006 Sep 29. Since Alzheimer's disease is known to be associated with down-regulation of the cholinergic and systems, most of these drugs inhibit acetylcholinesterase, potentiate the activity of nicotinic acetylcholine receptors (nAChRs), or modulate NMDA receptors. |
1(0,0,0,1) | Details |
| 12966175 | Holt JC, Lioudyno M, Guth PS: A pharmacologically distinct nicotinic receptor is found in a subset of frog semicircular canal hair cells. J Neurophysiol. 2003 Sep;90(3):1526-36. This -sensitive nicotinic receptor (RDMPP) was antagonized by the classic nicotinic antagonist d-tubocurarine, but refractory to strychnine, atropine, and propylbenzilylcholine mustard, at concentrations that completely block alpha9nAChR and/or mAChR. |
0(0,0,0,0) | Details |