| Name | NKCC1 |
|---|---|
| Synonyms | BSC; BSC 2; BSC2; Basolateral Na K Cl symporter; Bumetanide sensitive sodium potassium chloride cotransporter 1; Bumetanide sensitive sodium (potassium) chloride cotransporter 1; NKCC 1; NKCC1… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17681355 | Kilb W, Sinning A, Luhmann HJ: Model-specific effects of bumetanide on epileptiform activity in the in-vitro intact hippocampus of the newborn mouse. Neuropharmacology. 2007 Sep;53(4):524-33. Epub 2007 Jun 30. It has been recently suggested that bumetanide, which blocks Na (+)-dependent K (+)-Cl (-)-cotransporter isoform 1 (NKCC1) and thus attenuates depolarizing GABAergic responses, could soothe epileptiform activity in immature nervous systems. Inhibition of ligand-gated Cl (-) channels by 10 microM gabazine and 30 microM strychnine induced interictal activity (IA) that was only marginally affected by bumetanide. |
1(0,0,0,1) | Details |
| 18553216 | Shen W, Jiang Z, Li B: input induces the synaptic facilitation in salamander rod photoreceptors. J Biomed Sci. 2008 Nov;15(6):743-54. Epub 2008 Jun 16. Additionally, inhibition of a Cl (-) uptake transporter NKCC1 with bumetanid effectively eliminated -evoked a weak depolarization in rods, suggesting that NKCC1 maintains a high Cl (-) level in rods, which causes to depolarize in responding to input. |
1(0,0,0,1) | Details |