| Name | GABA B receptors |
|---|---|
| Synonyms | GABA B R1; GABA B receptor; GABA B receptor 1; GABAB(1e); GABABR 1; GABABR1; GABBR 1; GABBR1… |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12522177 | Matsumoto N, Kumamoto E, Furue H, Yoshimura M: -mediated inhibition of release during ischemia in substantia gelatinosa of the adult rat. J Neurophysiol. 2003 Jan;89(1):257-64. Superfusing TTX (1 microM)-containing ISM resulted in a similar recovery of spontaneous EPSC frequency and following increase (by 328 +/- 26%, n = 12) in the frequency; strychnine (1 microM) did not affect ISM-induced changes in spontaneous EPSC frequency (n = 5). It is concluded that the ischemic simulation inhibits excitatory transmission to SG neurons, whose action is in part mediated by the activation of presynaptic (A) and GABA (B) receptors, probably due to released from interneurons as a result of an ischemia-induced increase in neuronal activities. |
1(0,0,0,1) | Details |
| 18925381 | Maison SF, Casanova E, Holstein GR, Bettler B, Liberman MC: Loss of GABAB receptors in cochlear neurons: threshold elevation suggests modulation of outer hair cell function by type II afferent fibers. J Assoc Res Otolaryngol. 2009 Mar;10(1):50-63. Epub 2008 Oct 17. To explore the role of metabotropic GABA (B) receptors, we characterized the cochlear phenotype of mice with targeted deletion of the (B1) subunit and determined its tissue localization using a mouse line expressing a GFP-tagged (B1) subunit under the endogenous promoter. |
1(0,0,0,1) | Details |
| 11731558 | Keefer EW, Gramowski A, Gross GW: NMDA receptor-dependent periodic oscillations in cultured spinal cord networks. J Neurophysiol. 2001 Dec;86(6):3030-42. During disinhibition with bicuculline and strychnine, synchronized burst patterns routinely emerge. |
0(0,0,0,0) | Details |
| 11850512 | Mori M, Gahwiler BH, Gerber U: and as endogenous agonists at glycine receptors in rat hippocampus in vitro. J Physiol. 2002 Feb 15;539(Pt 1):191-200. In the presence of ionotropic and GABA (B) receptor antagonists, pressure-application of onto CA3 pyramidal cells induced a current associated with increased conductance, which was inhibited by strychnine. |
31(0,1,1,1) | Details |
| 11956334 | Zhang W, Barnbrock A, Gajic S, Pfeiffer A, Ritter B: Differential ontogeny of GABA (B)-receptor-mediated pre- and postsynaptic modulation of and transmission in respiratory rhythm-generating network in mouse. J Physiol. 2002 Apr 15;540(Pt 2):435-46. The effect of CGP on respiratory frequency was diminished in the presence of bicuculline and strychnine in older but not in younger animals. |
6(0,0,0,6) | Details |
| 16648160 | Grzywacz NM, Zucker CL: Modeling Starburst cells' GABA (B) receptors and their putative role in motion sensitivity. Biophys J. 2006 Jul 15;91(2):473-86. Epub 2006 Apr 28. |
5(0,0,0,5) | Details |
| 15026133 | Belluzzi O, Puopolo M, Benedusi M, Kratskin I: Selective neuroinhibitory effects of in slices of rat main olfactory bulb. Neuroscience. 2004;124(4):929-44. This action was mimicked by the (B) agonist baclofen and abolished by CGP 55845A; CGP 35348, which primarily blocks postsynaptic GABA (B) receptors, was ineffective. (A) antagonists, bicuculline and picrotoxin, blocked the actions, whereas the glycine receptor antagonist strychnine and (B) antagonists, CGP 55845A and CGP 35348, were ineffective. |
3(0,0,0,3) | Details |
| 10938323 | Chery N, De Koninck Y: GABA (B) receptors are the first target of released GABA at lamina I inhibitory synapses in the adult rat spinal cord. J Neurophysiol. 2000 Aug;84(2):1006-11. |
3(0,0,0,3) | Details |
| 14673187 | Whyment AD, Wilson JM, Renaud LP, Spanswick D: Activation and integration of bilateral -mediated synaptic inputs in neonatal rat sympathetic preganglionic neurones in vitro. J Physiol. 2004 Feb 15;555(Pt 1):189-203. Epub 2003 Dec 12. In three neurones IPSPs evoked by stimulation of the iLF (n = 1) or cLF (n = 2) were partly sensitive to strychnine (2 microM). The expression of postsynaptic (A) and GABA (B) receptors were confirmed by the sensitivity of SPNs to agonists, (2 mm), muscimol (10-100 microM) or baclofen (10-100 microM), in the presence of TTX, each of which produced membrane hyperpolarization in all SPNs tested. |
2(0,0,0,2) | Details |
| 10591891 | Jovanovic K, Petrov T, Stein RB: Effects of inhibitory neurotransmitters on the mudpuppy (Necturus maculatus) locomotor pattern in vitro. Exp Brain Res. 1999 Nov;129(2):172-84. Addition of glycine receptor antagonist strychnine or (A) receptor antagonist bicuculline disrupted the phase relationship between antagonistic motor pools during ongoing locomotion, thereby changing the normal alternating pattern into synchronous EMG bursts. Both the (A) receptor agonist muscimol and GABA (B) receptor agonist baclofen mimicked the effects of as they either slowed down or stopped locomotion. |
2(0,0,0,2) | Details |
| 9671104 | Garcia MC, Celuch SM, Adler-Graschinsky E: Involvement of and glutamate receptors in the blood pressure responses to intrathecally injected sodium nitroprusside in anesthetized rats. Eur J Pharmacol. 1998 May 22;349(2-3):245-52. The hypotensive effect of sodium nitroprusside was antagonized by the (A) receptor antagonists, bicuculline (4.4 nmol, i.t.) and picrotoxin (4.4 nmol, i.t.), and also by the GABA (B) receptor antagonist, 2- saclofen (113 nmol, i.t.). The blood pressure responses to sodium nitroprusside were not modified by blockade of muscarinic receptors with methyl atropine (164 nmol, i.t.), or of nicotinic receptors with hexamethonium (211 nmol, i.t.), of alpha1-adrenoceptors with prazosin (3.1 nmol, i.t.), of alpha2-adrenoceptors with yohimbine (2.8 micromol/kg, i.v.), of receptors with methysergide (5.1 micromol/kg, i.v.), or of glycine receptors with strychnine (65 nmol, i.t.). |
2(0,0,0,2) | Details |
| 10218807 | Rozzo A, Ballerini L, Nistri A: Antagonism by (1,2,5,6-tetrahydropyridine-4-yl) methylphosphinic acid of synaptic transmission in the neonatal rat spinal cord in vitro: an electrophysiological study. Neuroscience. 1999 Mar;90(3):1085-92. TPMPA significantly attenuated the depressant action of on spinal reflexes without changing responses induced by the (A) receptor agonist isoguvacine (50 microM) or the GABA (B) receptor agonist baclofen (0.5-2 microM). Following block of (A) receptors by bicuculline (20 microM) and of glycine receptors by strychnine (1 microM), regular bursting activity recorded from ventral roots developed spontaneously and persisted unchanged for many hours. |
1(0,0,0,1) | Details |
| 10559379 | Delaney AJ, Sah P: GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. J Neurosci. 1999 Nov 15;19(22):9698-704. The bicuculline-resistant IPSC was -selective and was unaffected by GABA (B)-receptor antagonists. |
1(0,0,0,1) | Details |
| 10686090 | Vergnes M, Boehrer A, Reibel S, Simler S, Marescaux C: Selective susceptibility to inhibitors of synthesis and antagonists of (A) receptor in rats with genetic absence epilepsy. Exp Neurol. 2000 Feb;161(2):714-23. The GABA (B) receptor antagonist CGP 56999 and kainic acid induced a similar incidence of seizures in GAERS and NE rats and predominantly activated the hippocampus. The susceptibility to convulsions induced by threshold doses of various GABA receptor antagonists and inhibitors of synthesis, kainic acid and strychnine, was compared in GAERS and in nonepileptic rats from a selected control strain (NE). |
1(0,0,0,1) | Details |
| 15688094 | Javitt DC, Hashim A, Sershen H: Modulation of striatal release by transport inhibitors. . Neuropsychopharmacology. 2005 Apr;30(4):649-56. Effects, of GTIs, were blocked by the -site antagonists L689,560 and HA-966, and the (B) antagonists phaclofen and CGP 52432, confirming the roles of both the -associated -site and presynaptic GABA (B) receptors in NMDA receptor-mediated regulation of striatal DA release in vitro. NMDA receptors in brain are regulated by acting via a strychnine-insensitive regulatory site, and by (GlyT1) transporters that maintain low levels in the immediate vicinity of the NMDA receptor complex. |
1(0,0,0,1) | Details |
| 7947393 | Boatright JH, Rubim NM, Iuvone PM: Regulation of endogenous release in amphibian retina by and Vis Neurosci. 1994 Sep-Oct;11(5):1003-12. Exogenous inhibited light-stimulated release in a concentration-dependent and strychnine-sensitive manner. Exogenous the -A receptor agonist muscimol, the GABA-B receptor agonist baclofen, and the -C receptor agonist cis-aminocrotonic acid (CACA) suppressed light-evoked overflow from eyecups. |
1(0,0,0,1) | Details |
| 17112484 | Heesch CM, Laiprasert JD, Kvochina L: RVLM glycine receptors mediate GABAA and GABAB) independent sympathoinhibition from CVLM in rats. Brain Res. 2006 Dec 13;1125(1):46-59. Epub 2006 Nov 16. In the presence of either ipsilateral (+contralateral NTS lesion; n=8) or bilateral (n=6) (A) and GABA (B) receptor blockade of the RVLM (400 pmol BIC+400 pmol CGP35348, 100 nl), inhibition of the CVLM still increased MAP and renal sympathetic nerve activity (RSNA). The addition of strychnine (300 pmol, 100 nl) to the RVLM eliminated responses to CVLM inhibition, suggesting that a (A) and (B) independent sympathoinhibitory influence from CVLM to RVLM is mediated by glycine receptors. |
1(0,0,0,1) | Details |