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Thoby-Brisson M, Telgkamp P, Ramirez JM: The role of the hyperpolarization-activated current in modulating rhythmic activity in the isolated respiratory network of mice. J Neurosci. 2000 Apr 15;20(8):2994-3005.
Voltage-clamp recordings (n = 90) indicate that cesium (Cs) (5 mM) blocked 77.2% of the I (h) current, and ZD 7288 (100 microM) blocked 85.8% of the I (h) current.
Most of the neurons expressing an I (h) current (86%) were pacemaker neurons, which continued to generate rhythmic bursts after inactivating the respiratory network pharmacologically with CNQX alone or with CNQX, AP-5, strychnine, bicuculline, and carbenoxolone. |
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