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Nishikawa T, Yamamoto N, Tsuchida H, Umino A, Kawaguchi N: [Endogenous D-serine in mammalian brains] . Nihon Shinkei Seishin Yakurigaku Zasshi. 2000 Feb;20(1):33-9.
It is well established that, like glycine and D-alanine, D-serine potentiates glutamate neurotransmission via the N-methyl-D-aspartate (NMDA) receptor by selective stimulation of its strychnine-insensitive glycine site and acts as a co-agonist of the glutamate receptor.
Recently, the conversion of L-serine to its D-form by serine racemase has been suggested by in vivo and in vitro experiments. |
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