| Name | beta adrenoceptor (protein family or complex) |
|---|---|
| Synonyms | Beta adrenoceptor; Beta adrenoceptor; Beta adrenergic receptor; Beta adrenergic receptors; Beta adrenoceptor; Beta adrenoceptors; Beta adrenoceptors |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8545484 | Layer RT, Popik P, Olds T, Skolnick P: Antidepressant-like actions of the polyamine site antagonist, eliprodil (SL-82.0715). Pharmacol Biochem Behav. 1995 Nov;52(3):621-7. Chronic treatment with eliprodil produced both a significant downregulation of beta-adrenoceptors and a reduction in the potency of to inhibit [3H] 5,7-dichlorokynurenic acid binding to strychnine-insensitive glycine receptors in neocortical membranes. |
31(0,1,1,1) | Details |
| 11129111 | Harkin A, Nally R, Kelly JP, Leonard BE: Effects of reboxetine and treatments alone and in combination on the binding properties of cortical and beta1-adrenergic receptors in an animal model of depression. J Neural Transm. 2000;107(10):1213-27. Changes to the binding properties of cortical and beta-adrenergic receptors have both been reported as potential indicators of antidepressant activity. A decrease in the potency of to displace the strychnine insensitive antagonist [3H] 5,7 dichlorokynurenic acid (5,7 DCKA) was observed in cortical homogenates of OB rats when compared to sham-operated controls. |
2(0,0,0,2) | Details |
| 8169857 | Paul IA, Nowak G, Layer RT, Popik P, Skolnick P: Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. J Pharmacol Exp Ther. 1994 Apr;269(1):95-102. Chronic (14 day) but not acute (1 day) treatment of mice with clinically active antidepressants produces a significant (approximately 1.8-4.3 fold) reduction in the potency of to inhibit [3H]-5,7-dichlorkynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine receptors in neocortical membranes. These findings indicate that the antidepressant-induced reduction in the IC50 of to inhibit [3H]-5,7-DCKA binding is: 1) a slowly developing, adaptive phenomenon; 2) remarkably persistent after cessation of treatment; and 3) a significantly better predictor of antidepressant activity (22 of 23 drugs) than either beta adrenoceptor down-regulation (15 of 23 drugs) or efficacy in the forced swim test (13 of 23 drugs) [P < .01 vs. each measure, Fisher's Exact Test]. |
1(0,0,0,1) | Details |
| 17110030 | Han SK, Park JR, Park SA, Chun SW, Lee JC, Lee SY, Ryu PD, Park SJ: inhibits substantia gelatinosa neurons in mice trigeminal subnucleus caudalis via alpha (2) and beta adrenoceptors. Neurosci Lett. 2007 Jan 10;411(2):92-7. Epub 2006 Nov 15. NA-induced hyperpolarizing effects were maintained in the presence of tetrodotoxin (TTX), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), d,l-2-amino-5-phosphonopentanoic acid (AP5), picrotoxin and strychnine, a Na (+) channel, ionotropic glutamate receptor, (A) and glycine receptor antagonists, respectively, indicating that the effects of NA are direct on the postsynaptic SG neurons. |
2(0,0,0,2) | Details |
| 9593880 | Miyazaki T, Kobayashi H, Tosaka T: Presynaptic inhibition by of the EPSC evoked in neonatal rat sympathetic preganglionic neurons. Brain Res. 1998 Apr 20;790(1-2):170-7. Monosynaptic excitatory postsynaptic currents (EPSCs) were evoked by electrical stimulation of the nucleus intercalatus in the presence of strychnine (5 microM) and bicuculline (10 microM). Conversely, the beta-adrenoceptor antagonist popranolol (5 microM), and the alpha1-, alpha2B- and alpha2C-antagonist prazosin (2 microM) were without effect. |
1(0,0,0,1) | Details |
| 9044387 | Hayar A, Feltz P, Piguet P: Adrenergic responses in silent and putative inhibitory pacemaker-like neurons of the rat rostral ventrolateral medulla in vitro. Neuroscience. 1997 Mar;77(1):199-217. Baseline spontaneous postsynaptic potentials were abolished by strychnine (1 microM), bicuculline (30 microM) or both. |
0(0,0,0,0) | Details |