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Kondratskaya EL, Pankratov YV, Lalo UV, Chatterjee SS, Krishtal OA: Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. Neurochem Int. 2004 Feb;44(3):171-7.
The effect of ginkgolide B on LTP did not alter considerably if GlyRs were blocked by strychnine (2 microM).
Platelet-activating factor (PAF), a biologically active lipid (1-O-alkyl-2-acetyl-sn-glycero-3-phosphoholine), is identified in different regions of brain, including hippocampus. |
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