| 16107637 |
Lozovaya N, Yatsenko N, Beketov A, Tsintsadze T, Burnashev N: Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids. J Neurosci. 2005 Aug 17;25(33):7499-506.
These effects of cannabinoids were observed in the presence of cannabinoid CB1/CB3, vanilloid receptor 1 antagonists, and the G-protein inhibitor GDPbetaS, suggesting a direct action of cannabinoids on GlyRs.
We also demonstrate that, in the presence of a GABA (A) receptor antagonist, GlyRs may contribute to the generation of seizure-like activity induced by short bursts (seven stimuli) of high-frequency stimulation of inputs to hippocampal CA1 region, because this activity was diminished by selective GlyR antagonists (strychnine and ginkgolides B and J). |
2(0,0,0,2) |
Details |