| Name | enkephalin |
|---|---|
| Synonyms | Met enkephalin; enkephalin; M enkephalin |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9518706 | Grudt TJ, Henderson G: and GABAA receptor-mediated synaptic transmission in rat substantia gelatinosa: inhibition by mu-opioid and GABAB agonists. J Physiol. 1998 Mar 1;507 ( Pt 2):473-83. This noise was abolished by strychnine (1 microM) but was insensitive to bicuculline (10 microM), TTX (0.5 microM), [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO, 1 microM) or baclofen (30 microM). |
6(0,0,1,1) | Details |
| 9772256 | Hayar A, Guyenet PG: Pre- and postsynaptic inhibitory actions of methionine-enkephalin on identified bulbospinal neurons of the rat RVL. J Neurophysiol. 1998 Oct;80(4):2003-14. The effects of -enkephalin (ME) on visualized bulbospinal neurons of the rostral ventrolateral medulla (RVL) were characterized in thin slices at 32 degrees C using the whole cell patch-clamp technique. The remaining mPSCs had much slower kinetics (decay time = 19.6 ms) and were GABAergic [miniature inhibitory postsynaptic currents (mIPSCs)] as they were blocked by gabazine (3 microM) but not by strychnine (3-10 microM). |
1(0,0,0,1) | Details |
| 8046463 | Glaum SR, Miller RJ, Hammond DL: Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord. J Neurosci. 1994 Aug;14(8):4965-71. Excitatory postsynaptic currents (EPSCs) or potentials (EPSPs) were evoked electrically at the ipsilateral dorsal root entry zone after blocking inhibitory inputs with bicuculline and strychnine, and NMDA receptors with D-2-amino-5-phosphonopentanoic acid. Bath application of the mu receptor agonist [D-Ala2, N-MePhe4, Gly5-ol] enkephalin (DAMGO) or the delta 1 receptor agonist [D-Pen2, D-Pen5] enkephalin (DPDPE) produced a long-linear, concentration-dependent reduction in the amplitude of the evoked EPSP/EPSC. |
1(0,0,0,1) | Details |
| 7858868 | Neal MJ, Paterson SJ, Cunningham JR: Enhancement of retinal release by DAMGO: possibly a direct opioid receptor-mediated excitatory effect. Br J Pharmacol. 1994 Nov;113(3):789-94. The mu-opioid receptor agonist, [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAMGO), when applied locally to the retina at concentrations between 1-30 microM significantly increased the light-evoked release of Blockade with bicuculline and strychnine of GABAergic and glycinergic inputs to the cholinergic neurones did not affect the action of DAMGO on release. |
1(0,0,0,1) | Details |
| 11160487 | Terman GW, Eastman CL, Chavkin C: Mu opiates inhibit long-term potentiation induction in the spinal cord slice. J Neurophysiol. 2001 Feb;85(2):485-94. Transverse slices were made from the lumbar spinal cord of 10- to 17-day-old rats, placed in a recording chamber, and perfused with artificial cerebrospinal fluid also containing bicuculline (10 microM) and strychnine (1 microM). Only LT-evoked field potentials were found to be reliably inhibited by the mu opioid receptor agonist [D- (2), N-Me- (4), Gly (5)] enkephalin-ol (DAMGO, 1 microM), although evoked potentials from both DR and LT were blocked by the AMPA/kainate glutamate receptor antagonist 6-cyano-7-nitroquinoxalene-2,3-dione. |
1(0,0,0,1) | Details |
| 11728420 | Jeong HJ, Lee JJ, Hahm ET, Han SH, Min BI, Cho YW: Role of protein kinase C in opioid modulation of -gated Cl (-) current in rat periaqueductal gray neuron. Eur J Pharmacol. 2001 Nov 16;431(2):143-50. The Role of protein kinase C in the modulatory effect of a mu-opioid receptor agonist, [D- (2),N-Me- (4),Gly (5)-ol] enkephalin (DAMGO), on the -gated Cl (-) current was examined in acutely dissociated rat periaqueductal gray neurons. The -gated Cl (-) current (I (Gly)) was sensitive to strychnine. |
1(0,0,0,1) | Details |
| 7820654 | Rick CE, Lacey MG: Rat substantia nigra pars reticulata neurones are tonically inhibited via GABAA, but not GABAB, receptors in vitro. Brain Res. 1994 Oct 3;659(1-2):133-7. The GABAB antagonist CGP 55845A (0.1 microM), while blocking the inhibitory action of baclofen, was without effect on spontaneous firing rate, as was strychnine (10 microM), the antagonist of and and also Met-enkephalin (10 microM). |
81(1,1,1,1) | Details |