| Name | GLYT2 |
|---|---|
| Synonyms | GGTA; GlyT2; GGTA 1; GGTA1; a1/3GTP; a1/3GTPs |
| Name | strychnine |
|---|---|
| CAS | strychnidin-10-one |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19085882 | Gimenez C, Zafra F, Lopez-Corcuera B, Aragon C: [Molecular bases of hereditary hyperekplexia] . Rev Neurol. 2008 Dec 16-31;47(12):648-52. Two major proteins involved in hyperekplexia are the strychnine-sensitive glycine receptor (GlyR) and the neuronal transporter GLYT2. |
82(1,1,1,2) | Details |
| 15081419 | Ebihara S, Yamamoto T, Obata K, Yanagawa Y: Gene structure and alternative splicing of the mouse transporter type-2. Biochem Biophys Res Commun. 2004 May 7;317(3):857-64. The type-2 transporter GLYT2 is expressed in glycinergic neurons and is involved in the termination of inhibitory neurotransmission at strychnine-sensitive glycinergic synapses. |
34(0,1,1,4) | Details |
| 18815261 | Rousseau F, Aubrey KR, Supplisson S: The transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. J Neurosci. 2008 Sep 24;28(39):9755-68. |
7(0,0,0,7) | Details |
| 17640406 | Jiang Z, Li B, Jursky F, Shen W: Differential distribution of transporters in Muller cells and neurons in amphibian retinas. Vis Neurosci. 2007 Mar-Apr;24(2):157-68. Our results indicated that GlyT1- and GlyT2-like transporters were present in Muller cells and neurons, respectively. |
7(0,0,0,7) | Details |
| 15588724 | Raiteri L, Stigliani S, Siri A, Passalacqua M, Melloni E, Raiteri M, Bonanno G: taken up through GLYT1 and GLYT2 heterotransporters into glutamatergic axon terminals of mouse spinal cord elicits release of by homotransporter reversal and through anion channels. Biochem Pharmacol. 2005 Jan 1;69(1):159-68. effect was insensitive to strychnine or 5,7-dichlorokynurenic acid, but was prevented by the transporter blocker glycyldodecylamide. |
4(0,0,0,4) | Details |
| 7861131 | Jursky F, Nelson N: Localization of neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor. J Neurochem. 1995 Mar;64(3):1026-33. A correlation was observed between the pattern we obtained and previously reported strychnine binding studies. |
4(0,0,0,4) | Details |
| 7823028 | Jursky F, Tamura S, Tamura A, Mandiyan S, Nelson H, Nelson N: Structure, function and brain localization of neurotransmitter transporters. J Exp Biol. 1994 Nov;196:283-95. A correlation as observed between the pattern we obtained and that observed previously from strychnine binding studies. The third transporter (GLYT2) is encoded by a separate gene. |
4(0,0,0,4) | Details |
| 11259500 | Raiteri L, Raiteri M, Bonanno G: is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter J Neurochem. 2001 Mar;76(6):1823-32. concentration dependently elicited [(3) H] release which was insensitive to strychnine or 5,7-dichlorokynurenic acid, but was Na (+) dependent and sensitive to the uptake blocker glycyldodecylamide. |
3(0,0,0,3) | Details |
| 20081141 | Haranishi Y, Hara K, Terada T, Nakamura S, Sata T: The antinociceptive effect of intrathecal administration of transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb;110(2):615-21. These antinociceptive effects were reversed completely by strychnine injected immediately after the administration of ALX1393. Neuronal isoform transporter-2 (GlyT2) reuptakes presynaptically released and regulates the glycinergic neurotransmission. |
3(0,0,0,3) | Details |
| 20173309 | Nishikawa Y, Sasaki A, Kuraishi Y: Blockade of transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain. J Pharmacol Sci. 2010 Mar 19;112(3):352-60. Epub 2010 Feb 20. is an inhibitory neurotransmitter in the spinal dorsal horn and its extracellular concentration is regulated by glial transporter (GlyT) 1 and neuronal GlyT2. Intrathecal ALX1393 suppressed dynamic allodynia induced by intrathecal strychnine and |
3(0,0,0,3) | Details |
| 17383967 | Vandenberg RJ, Shaddick K, Ju P: Molecular basis for substrate discrimination by transporters. J Biol Chem. 2007 May 11;282(19):14447-53. Epub 2007 Mar 23. is an inhibitory neurotransmitter in the spinal cord and brain stem, where it acts on strychnine-sensitive glycine receptors, and is also an excitatory neurotransmitter throughout the brain and spinal cord, where it acts on the family of receptors. There are two Na (+)/Cl (-)-dependent transporters, GLYT1 and GLYT2, which control extracellular concentrations and these transporters show differences in substrate selectivity and blocker sensitivity. |
2(0,0,0,2) | Details |
| 15555918 | Danglot L, Rostaing P, Triller A, Bessis A: Morphologically identified glycinergic synapses in the hippocampus. . Mol Cell Neurosci. 2004 Dec;27(4):394-403. Inhibitory transmission in the hippocampus is predominantly GABAergic, but electrophysiological data evidenced strychnine-sensitive -induced currents. Synaptic GlyRs were apposed to glycinergic boutons characterized by the expression of the vesicular and the plasma membrane transporters of (VIAAT and GlyT2, respectively). |
2(0,0,0,2) | Details |
| 12401451 | Meier J, Juttner R, Kirischuk S, Grantyn R: Synaptic anchoring of glycine receptors in developing collicular neurons under control of metabotropic glutamate receptor activity. Mol Cell Neurosci. 2002 Oct;21(2):324-40. Two distinct stages of inhibitory synaptogenesis in cultured collicular neurons were defined on the basis of strychnine sensitivity of IPSCs, presence of EPSCs, KCC2 expression, and transmitter-induced Ca (2+) responses. In the absence of KCC2 and glutamatergic transmission, newborn VIAAT-labeled boutons contained GlyT2, released and accumulated postsynaptic gephyrin and GlyRs. |
1(0,0,0,1) | Details |
| 11396606 | Lopez-Corcuera B, Geerlings A, Aragon C: neurotransmitter transporters: an update. Mol Membr Biol. 2001 Jan-Mar;18(1):13-20. This action of is mediated by the strychnine-sensitive glycine receptor, whose activation produces inhibitory post-synaptic potentials. It is believed that the termination of the different synaptic actions of is produced by rapid re-uptake through two -and--coupled transporters, GLYT1 and GLYT2, located in the plasma membrane of glial cells or pre-synaptic terminals, respectively. |
1(0,0,0,1) | Details |
| 10886333 | Belachew S, Malgrange B, Rigo JM, Rogister B, Leprince P, Hans G, Nguyen L, Moonen G: triggers an intracellular influx in oligodendrocyte progenitor cells which is mediated by the activation of both the ionotropic glycine receptor and Na+-dependent transporters. Eur J Neurosci. 2000 Jun;12(6):1924-30. -triggered Ca2+ influx in OP cells actually results from an initial depolarization that is the consequence of the activation of both the ionotropic glycine receptor (GlyR) and Na+-dependent transporters, most probably the transporters 1 (GLYT1) and/or 2 (GLYT2) which are colocalized in these cells. |
1(0,0,0,1) | Details |
| 15031290 | Ju P, Aubrey KR, Vandenberg RJ: Zn2+ inhibits transport by transporter subtype 1b. J Biol Chem. 2004 May 28;279(22):22983-91. Epub 2004 Mar 18. In the central nervous system, is a co-agonist with at the subtype of glutamate receptors and also an agonist at inhibitory, strychnine-sensitive glycine receptors. The GLYT1 subtypes of transporters (GLYTs) are responsible for regulation of at excitatory synapses, whereas a combination of GLYT1 and GLYT2 subtypes of transporters are used at inhibitory glycinergic synapses. |
1(0,0,0,1) | Details |
| 16381810 | Song W, Chattipakorn SC, McMahon LL: -gated channels depress synaptic transmission in rat hippocampus. J Neurophysiol. 2006 Apr;95(4):2366-79. Epub 2005 Dec 28. An inhibitory role for strychnine-sensitive -gated channels (GlyRs) in mature hippocampus is beginning to be appreciated. Finally, using immunohistochemical methods, we show that and the transporter GlyT2 are co-localized selectively in GABAergic interneurons, indicating that interneurons contain both inhibitory neurotransmitters. |
1(0,0,0,1) | Details |
| 15235081 | Bradaia A, Schlichter R, Trouslard J: Role of glial and neuronal transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J Physiol. 2004 Aug 15;559(Pt 1):169-86. Epub 2004 Jul 2. We used ORG 24598 and ORG 25543, selective antagonists of the glial GlyT (GlyT1) and neuronal GlyT (GlyT2), respectively. By contrast, the decay time constant, amplitude and frequency of miniature GABAergic IPSCs recorded in the presence of strychnine were not affected by ORG 24598 and ORG 25543. |
1(0,0,0,1) | Details |
| 18553216 | Shen W, Jiang Z, Li B: input induces the synaptic facilitation in salamander rod photoreceptors. J Biomed Sci. 2008 Nov;15(6):743-54. Epub 2008 Jun 16. Using specific antibodies against a transporter (GlyT2) and glycine receptor beta subunit, we identified the morphology of glycinergic input in photoreceptor terminals. |
1(0,0,0,1) | Details |
| 17522628 | Zhang LH, Gong N, Fei D, Xu L, Xu TL: uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology. 2008 Feb;33(3):701-11. Epub 2007 May 23. Antagonists of GlyT type 1 (GlyT1) but not that of GlyT type 2 (GlyT2) induced excitatory postsynaptic potential (EPSP)-spike depression, which was reversed by the specific GlyR antagonist strychnine. |
0(0,0,0,0) | Details |