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Elliott P, Wallis DI, Foster GA, Stringer BM: Ionic mechanisms underlying excitatory effects of serotonin on embryonic rat motoneurons in long-term culture. Neuroscience. 1999;90(4):1311-23.
Trophic support was provided by a spinal cord glial monolayer, ciliary neurotrophic factor and heat-inactivated serum.
Serotonin evoked slow depolarizations (6.2+/-0.7 or 9.3+/-1.3 mV in the presence of 6-cyano-7-nitroquinoxaline-2,3-dione and strychnine, EC50 8.2 nM), which were reversibly blocked by 0.1 microM ketanserin. |
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