Protein Information

Name adenylyl cyclase
Synonyms ADCY 7; ATP pyrophosphate lyase; Adenylyl cyclase; ADCY7; ADCY7 protein; ATP pyrophosphate lyase 7; Adenylate cyclase 7; Adenylate cyclase type 7…

Compound Information

Name strychnine
CAS strychnidin-10-one

Reference List

PubMed Abstract RScore(About this table)
7913402 Puebla L, Arilla E: Somatostatin receptor-GTP binding regulatory protein-adenylyl cyclase system in hippocampal membranes of strychnine-treated rats. Brain Res. 1994 Apr 25;644(1):59-66.
62(0,2,2,2) Details
8714523 Puebla L, Arilla E: Glycine increases the number of somatostatin receptors and somatostatin-mediated inhibition of the adenylate cyclase system in the rat hippocampus. J Neurosci Res. 1996 Feb 1;43(3):346-54.

Since SS receptors are coupled via guanine nucleotide-binding G proteins to the adenylyl cyclase (AC) system, we also examined the inhibitory effects of SS and the guanine nucleotide Gpp (NH) p on AC activity in hippocampal membranes of control, glycine- and strychnine plus glycine-treated rats since the increase in SS receptors was observed only in this brain area.
31(0,1,1,1) Details
8987801 Bonci A, Williams JT: Increased probability of GABA release during withdrawal from morphine. . J Neurosci. 1997 Jan 15;17(2):796-803.


In addition, activation of adenylyl cyclase, with forskolin, and cAMP-dependent protein kinase, with Sp-cAMPS, caused a larger increase in IPSCs in slices from morphine-treated animals.
1(0,0,0,1) Details
11312281 Hatton GI, Yang QZ: Ionotropic histamine receptors and H2 receptors modulate supraoptic oxytocin neuronal excitability and dye coupling. J Neurosci. 2001 May 1;21(9):2974-82.

Because H (2) receptors are linked to activation of adenylyl cyclase, TM-stimulated reduction in coupling was blocked by GDP-betaS, pertussis toxin, and Rp-cAMPs and was mimicked by 8-bromo-cAMP, 3-isobutyl-1-methylxanthine, and Sp-cAMP.
IPSPs were blocked by the Cl (-) channel blocker picrotoxin, but not by bicuculline or strychnine, and by histamine H (2), but not by H (1) or H (3) receptor antagonists, suggesting the presence of an ionotropic histamine receptor and the possible nonspecificity of currently used H (2) antagonists.
1(0,0,0,1) Details