| 19959465 |
Melzer N, Villmann C, Becker K, Harvey K, Harvey RJ, Vogel N, Kluck CJ, Kneussel M, Becker CM: Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting. J Biol Chem. 2010 Feb 5;285(6):3730-9. Epub 2009 Dec 3.
The strychnine-sensitive glycine receptor (GlyR) is a ligand-gated ion channel that mediates fast synaptic inhibition in the vertebrate central nervous system.
In yeast two-hybrid screening and GST pulldown assays, karyopherin alpha3 and alpha4 were found to interact with the TM3-4 loop, providing a molecular mechanism for the observed intracellular trafficking. |
1(0,0,0,1) |
Details |